Propofol is a Medicine belongs to intravenous anesthetics group whose information about Brand can be referenced from   Book : Martindale    Page : 1950   Edition : 37,

  ►   Brandname : Diprivan,Propoven

  ►  Strength : Injection with 10  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 446   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 1949   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Induction of anaesthesia IV 1.5 2.5 mg/kg Injection
2 Sedation IV infusion 6 9 mg/kg/hour Injection May be given for 3 to 5 minutes.

Ref :-  Book : Martindale    Page : 1949   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Induction of anaesthesia <8 Year IV 2.5 mg/kg Injection

Ref :- Book : Martindale    Page : 1949   Edition : 37,
►  Side Effect : decrease in blood pressure, respiratory depression, Anaphylactoid reactions, propofol infusion syndrome, fever, Pancreatitis,
Ref :-   Book : Martindale    Page : 1947   Edition : 37,

►  Drug Interaction : Drug interaction of Propofol is with Atracurium , Suxamethonium chloride,
Ref :-   Book : Martindale    Page : 1948   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The use of propofol with other CNS depressants, including those used in premedication, may increase the sedative, anaesthetic, and cardiorespiratory depressant effects of propofol. It is recommended that propofol is given after opioids so that the dose of propofol can be carefully titrated against the response.,
Ref :-   Book : Martindale    Page : 1948   Edition : 37,


►  Contraindication : , Epilepsy, lipid metabolism disorder,
Ref :-   Book : Martindale    Page : 1948   Edition : 37,
  ►  Mechanism of Action :   The presumed mechanism of action of propofol is through potentiation of the chloride current mediated through the GABA A receptor complex.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 439   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Basic & Clinical pharmacology    Page : 439   Edition : 12,


►    Plasma Half-life :
  Min value :-   4 hours,    Max value :-   23 hours,
Ref :-   Book : Basic & Clinical pharmacology    Page : 439   Edition : 12,

►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
Ref :-   Book :    Page :    Edition : ,