Propranolol is a Medicine belongs to Adrenoceptor blockers / Antihypertensive group whose information about Brand can be referenced from   Book : Martindale    Page : 1517   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Betabloc,Betaspan,Ciplar,Angilol,Bedranol,Beta-Prograne,Inderal,InnoPran,Betacap,Petril Beta,Ciplar LA

  ►  Strength : Tablet with 10  mg, Tablet with 20  Mg, Tablet with 40  Mg, Tablet with 60  Mg, Tablet with 80  mg, Tablet with 90  mg, Solution with 4  mg/ml, Solution with 8  mg/ml, Capsule with 60  Mg, Capsule with 80  Mg, Capsule with 120  Mg, Capsule with 160  mg, Injection with 1  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 189   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 1516   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 hypertension Oral 40 80 mg b.d.
2 Phaeochromocytoma Oral 60 mg Daily on the 3 days before the operation.
3 Angina pectoris Oral 40 mg b.d/t.i.d
4 Myocardial infarction Oral 40 mg q.i.d.
5 Arrhythmia Oral 30 160 mg Daily in divided doses.
6 Hypertrophic cardiomyopathy Oral 10 40 mg t.i.d/q.i.d
7 Hyperthyroidism Oral 10 40 mg t.i.d/q.i.d
8 Anxiety Oral 40 mg Daily.
9 Essential tremor Oral 40 mg b.d/t.i.d
10 Migraine Oral 40 mg b.d/t.i.d
11 Portal hypertension Oral 40 mg b.d.

Ref :-  Book : Martindale    Page : 1516   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 hypertension > 1 Day > 28 Day Oral 250 micrograms/kg t.i.d.
2 hypertension 1 Month 12 Year Oral 0.25 1 mg/kg t.i.d.
3 hypertension 12 Year <12 Year Oral 40 80 mg b.d.
4 Arrhythmias > 1 Day > 28 Day Oral 250 500 mg/kg t.i.d.
5 Arrhythmias 1 Month 18 Year Oral 250 500 micrograms/kg t.i.d/q.i.d
6 Phaeochromocytoma > 1 Day > 28 Day Oral 250 500 micrograms/kg t.i.d.
7 Phaeochromocytoma 1 Month 18 Year Oral 250 500 micrograms/kg t.i.d/q.i.d
8 Hyperthyroidism > 1 Day > 28 Day Oral 250 500 micrograms/kg t.i.d.
9 Hyperthyroidism 1 Month 18 Year Oral 250 500 micrograms/kg t.i.d/q.i.d
10 Prophylaxis of migraine 12 Year Oral 10 20 mg b.d/t.i.d
11 Prophylaxis of migraine <12 Year Oral 40 mg b.d/t.i.d

Ref :- Book : Martindale    Page : 1516   Edition : 37,
►  Organ Affected Respiratory diseases-(May precipitate bronchial asthma)  

Precaution :- If a Patient is using 'Propranolol' drug in  Heart failure  disease, then Please TO BE AVOIDED .

Precaution :- If a Patient is using 'Propranolol' drug in  MYASTHENIA GRAVIS  disease, then Please Use with caution .

►  Side Effect : bradycardia, hypotension, headache, Depression, Dizziness, hallucinations, Confusion, amnesia, Sleep disturbances, nightmares, fatigue, arthralgia, myalgia, myopathies, muscle cramp, nausea, vomiting, diarrhea, constipation, abdominal cramping, exacerbation of psoriasis, excess sweating, reversible alopecia, Decreased tear production, Blurred Vision, conjunctivitis, soreness, nonthrombocytopenic purpura, thrombocytopenia, Raynaud’s syndrome, agranulocytosis, transient eosinophilia, sclerosing peritonitis, retroperitoneal fibrosis, Psychosis, delirium,
Ref :-   Book : Martindale    Page : 1350,1351   Edition : 37,

►  Drug Interaction : Drug interaction of Propranolol is with Aldesleukin , Testosterone , Ropivacaine , Digoxin , Rifampicin , Cimetidine , Erythromycin , Fluvoxamine, Hydralazine , Labetalol , Propranolol , Timolol , Atenolol , Nadolol,
Ref :-   Book : Martindale    Page : 1352   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Drugs that cause hypotension such as aldesleukin and general anaesthetics also enhance the antihypertensive effects of beta blockers while other drugs, for example NSAIDs, antagonise the antihypertensive effects. Use of beta blockers with other cardiac depressants such as antiarrhythmics and rate-limiting calcium channel blockers can precipitate bradycardia and heart block; the combination of intravenous verapamil and beta blockers should especially be avoided. Beta blockers may potentiate bradycardia due to digoxin. In diabetic patients beta blockers can reduce the response to insulin and oral hypoglycaemics through their effects on pancreatic beta receptors. Metabolism of some beta blockers can be increased by drugs such as barbiturates and rifampicin and decreased with drugs such as cimetidine, erythromycin, fluvoxamine, and hydralazine. Cimetidine and hydralazine decrease hepatic blood flow and this contributes to the decreased hepatic clearance seen with these drugs. Drugs that influence hepatic metabolism affect beta blockers that are extensively metabolised, such as labetalol, propranolol, and timolol, while beta blockers that are excreted largely unchanged, for example atenolol and nadolol, are unaffected.,
Ref :-   Book : Martindale    Page : 1352   Edition : 37,


►  Absolute Contraindication : Bronchospasm or asthma   obstructive airways disease   acidosis   cardiogenic shock   hypotension   severe peripheral arterial disease   sinus bradycardia   and second- or third-degree AV block   Prinzmetal’s angina   pregnancy.  

►  Contraindication : asthma, acidosis, cardiogenic shock, , peripheral arterial disease, Sinus bradycardia, pregnancy,
Ref :-   Book : Martindale    Page : 1351   Edition : 37,
  ►  Mechanism of Action :   Block β-adrenergic receptors; this class of drugs can be divided into nonselective β- and α1-antagonists, partial agonist, and β1-selective antagonists. ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 146   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Pomegranate with Another pathway,

  ►  Pathway with its reference as follows :-
  • have hypertensive property due to tannins --- (15. Aviram, M., Rosenblat, M., Gaitini, D., Nitecki, S., Hoffman, A., & Dornfeld, L. et al. (2004). Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clinical Nutrition, 23(3), 423-433. )

  •   ►  URL -- http://www.ncbi.nlm.nih.gov/pubmed/15158307,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- COQ10 with Decrease in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- COQ10 with It inhibits enzymes dependent on coenzyme Q 10 .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 1516   Edition : 37,


    ►    Plasma Half-life :   Min value :-   3 hours,    Max value :-   6 hours,
    Ref :-   Book : Martindale    Page : 1516   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 1516   Edition : 37,