Propylthiouracil is a Medicine belongs to Antithyroid agent group whose information about Brand can be referenced from   Book : Martindale    Page : 2376   Edition : 37,

  ►   Brandname : Propycil

  ►  Strength : Tablet with 50  Mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 695   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 2376   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Thyroid storm Oral 200 400 mg Tablet Daily.

Ref :-  Book : Martindale    Page : 2343   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Hyperthyroidism > 1 Day > 28 Day Oral 2.5 5 mg/kg Tablet b.d.
2 Hyperthyroidism 1 Month 1 Year Oral 2.5 mg/kg Tablet t.i.d.
3 Hyperthyroidism 1 Year 5 Year Oral 25 mg Tablet t.i.d.
4 Hyperthyroidism 5 Year 12 Year Oral 50 mg Tablet t.i.d.
5 Hyperthyroidism 12 Year 18 Year Oral 100 mg Tablet t.i.d.

Ref :- Book : Martindale    Page : 2376   Edition : 37,
►  Organ Affected Hematopoietic toxicity (Agranulocytosis)  

Precaution :- If a Patient is using 'Propylthiouracil' drug in  alcoholic cirrhosis  disease, then Please CAN CAUSE DRUG INDUCED VASCULITIS .

►  Side Effect : vomiting, gastric discomfort, headache, arthralgia, Skin rashes, pruritus, hepatitis, hepatic necrosis, encephalopathy, death, liver damage,
Ref :-   Book : Martindale    Page : 2367,2376   Edition : 37,

►  Drug Interaction : Drug interaction of Propylthiouracil is with NA

  ►    Mechanism of Drug Drug Interaction :  nf,
Ref :-   Book :    Page :    Edition : ,


►  Contraindication : hepatic impairment, renal impairment,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 2376   Edition : 37,
  ►  Mechanism of Action :   Propylthiouracil is a thiourea antithyroid drug that acts by blocking the production of thyroid hormones (see p.2165); it also inhibits the peripheral deiodination of thyroxine to tri-iodothyronine.,
Ref :-   Book : Martindale    Page : 2376   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Motherwort with Another pathway,

  ►  Pathway with its reference as follows :-
  • Diterpene have immunomodulating property activity --- (Pdr For Herbal Medicine. 4th ed. 2016. Print. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 2376   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   1 hours,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 2376   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 2376   Edition : 37,