Protamine sulphate is a Medicine belongs to Anticoagulant group whose information about Brand can be referenced from   Book : Martindale    Page : 1603   Edition : 37,

  ►   Brandname : Prosulf,Prota

  ►  Strength : Injection with 10  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 617   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, SC,
Reference :-   Book : Martindale    Page : 1603   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Haemorrhage IV 50 mg Injection

Ref :-  Book : Martindale    Page : 1572   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : hypotension, bradycardia, dyspnoea, sensation of warmth, nausea, vomiting, lassitude, hypersensitivity reactions, hypersenstivity,
Ref :-   Book : Martindale    Page : 1603   Edition : 37,

►  Drug Interaction : Drug interaction of Protamine sulphate is with Heparin ,
Ref :-   Book : Martindale    Page : 1603   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Protamine is a basic protein that combines with heparin to form a stable inactive complex. Protamine is used to neutralise the anticoagulant action of heparin in the treatment of haemorrhage resulting from severe heparin or low-molecular-weight heparin overdosage.,
Ref :-   Book : Martindale    Page : 1603   Edition : 37,


►  Contraindication : Hypersensitivity,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 400   Edition : 3,
  ►  Mechanism of Action :   Inactivates heparin by forming a stable 1:1 protamine:heparin complex,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 400   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   NA


►    Plasma Half-life :
  Min value :-   NA    Max value :-   NA


►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA