Protamine sulphate is a Medicine belongs to Anticoagulant group whose information about Brand can be referenced from   Book : Martindale    Page : 1603   Edition : 37  

  ►   Brandname : Prosulf, Prota
  ►  Strength : Injection with 10 mg/ml. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 617   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, SC
Reference :-   Book : Martindale    Page : 1603   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Haemorrhage IV 50 mg Injection

Ref :-  Book : Martindale    Page : 1572   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Hypotension, Bradycardia, Dyspnoea, Sensation of warmth, Nausea, Vomiting, Lassitude, Hypersensitivity reactions, Hypersenstivity
Ref :-   Book : Martindale    Page : 1603   Edition : 37.  

►  Drug Interaction : Drug interaction of Protamine sulphate is with Heparin
Ref :-   Book : Martindale    Page : 1603   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  Protamine is a basic protein that combines with heparin to form a stable inactive complex. Protamine is used to neutralise the anticoagulant action of heparin in the treatment of haemorrhage resulting from severe heparin or low-molecular-weight heparin overdosage.
Ref :-   Book : Martindale    Page : 1603   Edition : 37.  


►  Contraindication : Hypersensitivity
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 400   Edition : 3.  
  ►  Mechanism of Action :   Inactivates heparin by forming a stable 1:1 protamine:heparin complex
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 400   Edition : 3.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   NA

►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA