Protamine sulphate is a Medicine belongs to Chelators Antidotes and Antagonists group whose information about Brand can be referenced from   Book : Martindale    Page : 1572   Edition : 38  

  ►   Brandname : Prosulf; Neutrahep; Newtain, Prota
  ►  Strength : Injection with 10 mg/ml. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 617   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, SC, Intermittent injection
Reference :-   Book : Martindale    Page : 1572   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Haemorrhage IV Not more than 50 mg Injection For any one dose.

Ref :-  Book : Martindale    Page : 1572   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1

Ref :- Book :    Page :    Edition :   
►  Side Effect : Hypotension, Bradycardia, Dyspnoea, Sensation of warmth, Nausea, Vomiting, Lassitude, Back pain, Transient flushing,, Anaphylactoid reactions, Circulatory collapse, Myocardial infraction, Pulmonary hypertension, Capillary leak, Systemic hypertension, Angioedema, Respiratory distress, Fatal anaphylaxis, Severe left ventricular dysfunction and abnormal pulmonary haemodynamics
Ref :-   Book : Martindale    Page : 1572   Edition : 38.  

►  Drug Interaction : Drug interaction of Protamine sulphate is with NA

  ►    Mechanism of Drug Drug Interaction :  N.F.R.B
Ref :-   Book :    Page :    Edition : .  


►  Contraindication : Hypersensitivity to Protamine
Ref :-   Book : Martindale    Page : 1572   Edition : 38.  
  ►  Mechanism of Action :   Inactivates heparin by forming a stable 1:1 protamine:heparin complex
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 400   Edition : 3.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   NA

►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA