Pyrazinamide is a Medicine belongs to DRUGS USED IN TUBERCULOSIS group whose information about Brand can be referenced from   Book : Martindale    Page : 347   Edition : 38,    Page :   Edition : ,

  ►   Brandname : Actizid,Antizide,Copyrazin,Zinamide,Akurit 4

  ►  Strength : Tablet with 500  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 848   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 848   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Tuberculosis Oral 1.5 gm Tablet Daily.
2 Tuberculosis Oral 2 gm Tablet Three times weekly.
3 Tuberculosis Oral 1.5 3 gm Tablet Three times weekly.

Ref :-  Book : Martindale    Page : 345   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Tuberculosis 5 kg to 30 kg Oral 30 40 mg/kg Tablet o.d.

Ref :- Book : Martindale    Page : 345   Edition : 38,
Precaution :- If a Patient is using 'Pyrazinamide' drug in  TUBERCULOSIS  disease, then Please Contraindications Severe hepatic damage, acute gout, hypersensitivity. .

Precaution :- If a Patient is using 'Pyrazinamide' drug in ACUTE VIRAL HEPATITIS disease, then Please avoid   if he ever suffered from TUBERCULOSIS disease.
Precaution :- If a Patient is using 'Pyrazinamide' drug in AUTOIMMUNE HEPATITIS disease, then Please Use with caution   if he ever suffered from TUBERCULOSIS disease.
►  Side Effect : hepatotoxicity, hepatitis, hyperuricaemia, attacks of gout, Increase in liver enzyme values, hepatomegaly, splenomegaly, jaundice, anorexia, nausea, vomiting, aggravation of peptic ulcer, arthralgia, malaise, fever, sideroblastic anaemia, thrombocytopenia, porphyria, dysuria, photosensitivity, pellagra, Skin rashes,
Ref :-   Book : Martindale    Page : 345   Edition : 38,

►  Drug Interaction : Drug interaction of Pyrazinamide is with Probenecid , Allopurinol , Zidovudine,
Ref :-   Book : Martindale    Page : 346   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  The complex interactions occurring when pyrazinamide and probenecid are given to patients with gout have been studied. Probenecid is known to block the excretion of pyrazinamide. A pharmacokinetic study in 6 healthy subjects found that allopurinol, a xanthine oxidase inhibitor, increases concentrations of pyrazinoic acid (the main metabolite of pyrazinamide) thereby worsening pyrazinamide-induced hyperuricaemia. Low or undetectable concentrations of pyrazinamide occurred in 4 patients also taking zidovudine. ,
Ref :-   Book : Martindale    Page : 346   Edition : 38,


►  Contraindication : hepatic disease, acute gout, jaundice, renal disease, Diabetes mellitus, Porphyria,
Ref :-   Book : Martindale    Page : 346   Edition : 38,
  ►  Mechanism of Action :   Pyrazinamide is converted to pyrazinoic acid – the active form of the drug – by mycobacterial pyrazinamidase, which is encoded by pncA. The specific drug target is unknown, but pyrazinotic acid disrupts mycobacterial cell membrane metabolism and transport functions. ,
Ref :-   Book : Basic & Clinical pharmacology    Page : 842   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- with Another pathway, with Another pathway,

  ►  Pathway with its reference as follows :-
  • Anti tubercular effect --- ( PDR for Herbal medicines. (2000) (4th ed.). U.S. )
  • Silicic acid have Anti tubercular effect --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 349   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   9 hours,    Max value :-   10 hours,
    Ref :-   Book : Martindale    Page : 349   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 349   Edition : 37,