Pyridostigmine is a Medicine belongs to CHOLINESTERASE INHIBITORS group whose information about Brand can be referenced from   Book : Martindale    Page : 690   Edition : 37,

  ►   Brandname : Distinon,Mestinon

  ►  Strength : Tablet with 30  mg, Tablet with 60  mg, Tablet with 180  Mg, Syrup with 12  mg/ml, Injection with 5  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 112   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, Oral,
Reference :-   Book : Martindale    Page : 689   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Myasthenia Gravis Oral Tablet Daily 300 mg to 1.2 g.
2 Reversal of neuromuscular blockade IV 100 250 micrograms/kg Injection
3 Paralytic Ileus Oral 60 240 mg Tablet
4 Urinary retention Oral 60 240 mg Tablet

Ref :-  Book : Martindale    Page : 689   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Myasthenia Gravis > 6 Year Oral 30 mg Tablet
2 Myasthenia Gravis 6 Year 12 Year Oral 60 mg Tablet

Ref :- Book : Martindale    Page : 689   Edition : 37,
Precaution :- If a Patient is using 'Pyridostigmine' drug in  MYASTHENIA GRAVIS  disease, then Please be given .

►  Side Effect : increased salivation, nausea, vomiting, abdominal cramp, diarrhea, Rashes, excess sweating, Lacrimation, Increased Peristalsis, Involuntary Defaecation, involuntary urination, Miosis, Ciliary Spasm, nystagmus, bradycardia, Fasciculation, Paralysis, wheezing,
Ref :-   Book : Martindale    Page : 687   Edition : 37,

►  Drug Interaction : Drug interaction of Pyridostigmine is with Erythromycin , Clindamycin , Colistin, Zonisamide , Quinine , Chloroquine , Hydroxychloroquine , Quinidine , Procainamide , Propafenone, Felbamate, Suxamethonium chloride,
Ref :-   Book : Martindale    Page : 686,687,689   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Pyridostigmine, can inhibit the metabolism of suxamethonium and enhance and prolong its action; combined use is not intended. Antimuscarinics such as atropine antagonise the muscarinic effects of neostigmine Drugs with neuromuscular blocking activity, such as the aminoglycosides, clindamycin, colistin, cyclopropane, and the halogenated inhalational anaesthetics, may antagonise the effects of pyridostigmine,
Ref :-   Book : Martindale    Page : 686,687,689   Edition : 37,


►  Contraindication : Gastrointestinal obstruction, Urinary-Tract Obstruction, Peritonitis,
Ref :-   Book : Martindale    Page : 687   Edition : 37,
  ►  Mechanism of Action :   Inhibit acetylcholinesterase(AChE) by binding to the enzymes active site,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 128   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Cayenne with Another pathway,

  ►  Pathway with its reference as follows :-
  • Capsaicinoids have Muscle relaxant activity --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Goodman    Page :    Edition : 12,


    ►    Plasma Half-life :
      Min value :-   1 hours,    Max value :-   2 hours,
    Ref :-   Book : Goodman    Page :    Edition : 12,

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   5 hours,
    Ref :-   Book : Martindale    Page : 689   Edition : 37,