Pyrimethamine is a Medicine belongs to antimalarial group whose information about Brand can be referenced from   Book : Martindale    Page : 666   Edition : 37,

  ►   Brandname : Daraprim,Fansidar

  ►  Strength : Tablet with 25  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 837   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 837   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Malaria Oral 1.25 mg/kg Tablet Given for 3 days with sulfadoxine 25 mg/kg.

Ref :-  Book : Martindale    Page : 662   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Uncomplicated falciparum malaria Oral 1.25 mg/kg Tablet o.d.
2 Uncomplicated falciparum malaria 2 Month <2 Month 5 kg to 10 kg Oral 12.5 mg Tablet
3 Uncomplicated falciparum malaria 2 Month <2 Month 11 to 20 kg Oral 25 mg Tablet
4 Uncomplicated falciparum malaria 2 Month <2 Month 21 to 30 kg Oral 37.5 mg Tablet
5 Uncomplicated falciparum malaria 2 Month <2 Month 31 to 45 kg Oral 50 mg Tablet
6 Uncomplicated falciparum malaria 2 Month <2 Month < 45 kg Oral 1.25 mg/kg Tablet

Ref :- Book : Martindale    Page : 665   Edition : 37,
►  Side Effect : Skin rashes, hypersenstivity, headache, Dizziness, insomnia, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, agranulocytosis, eosinophilia, Depression, haematopoiesis,
Ref :-   Book : Martindale    Page : 664   Edition : 37,

►  Drug Interaction : Drug interaction of Pyrimethamine is with cotrimoxazole, Trimethoprim , Methotrexate, Phenytoin ,
Ref :-   Book : Martindale    Page : 665   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Use of pyrimethamine with other folate antagonists such as co-trimoxazole, trimethoprim, methotrexate, or phenytoin may exacerbate bone marrow depression. ,
Ref :-   Book : Martindale    Page : 665   Edition : 37,


►  Contraindication : Megaloblastic anemia, pregnancy, hepatic insufficiency, renal insufficiency, Porphyria,
Ref :-   Book : Martindale    Page : 664-665   Edition : 37,
  ►  Mechanism of Action :   Folate analogues that competitively inhibit microbial dihydrofolate reductase (DHFR) and thereby prevent the regeneration of tetrahydrofolate from dihydrofolate.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 579   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Neem with Another pathway,

  ►  Pathway with its reference as follows :-
  • Rosmarinic acid have antimalarial activity --- (Prophylatic Potential of Lemon Grass and Neem as Antimalarial Agents. (2010). Journal Of American Science, 6(8). )

  •   ►  URL -- http://www.jofamericanscience.org/journals/am-sci/am0608/62_3089am0608_503_507.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- FOLATE with Impairs vit metabolism,folate antagonizes activity., VITAMIN B12 with Impairs vitamin metabolism .,

      ►  Reference :-
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 665   Edition : 37,


    ►    Plasma Half-life :   Min value :-   96 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 665   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   6 hours,
    Ref :-   Book : Martindale    Page : 665   Edition : 37,