Quetiapine is a Medicine belongs to Antipsychotic group whose information about Brand can be referenced from   Book : Martindale    Page : 1130   Edition : 37,

  ►   Brandname : Quel,Seroquin,Seroquel

  ►  Strength : Tablet with 25  mg, Tablet with 50  mg, Tablet with 100  mg, Tablet with 200  mg, Tablet with 300  mg, Tablet with 400  mg, Tablet (Extended Release Tablets) with 200  Mg, Tablet (Extended Release Tablets) with 300  mg, Tablet (Extended Release Tablets) with 400  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 519   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1129   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Schizophrenia Oral 50 mg Tablet Dose: Based on day one given in 2 divided doses.
2 Bipolar disorder Oral 50 mg Tablet o.d. Dose: Given 100 mg twice daily on day two, 150 mg twice daily on day three, and 200 mg twice daily on day four.
3 Unipolar depression Oral 50 mg Tablet o.d. Dose: Given daily on days one and two, increased to the usual dose of 150 mg once daily on day three; thereafter, the dose may be increased to a maximum of 300 mg daily as necessary.
4 Cardiac arrhythmias Oral 200 400 mg t.i.d/q.i.d

Ref :-  Book : Martindale    Page : 1129   Edition : 37, Martindale    Page : 1520   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Schizophrenia 13 Year 17 Year Oral 50 mg Tablet
2 Schizophrenia 13 Year 17 Year Oral 50 mg Tablet
3 13 Year 17 Year Oral 50 mg Tablet

Ref :- Book : Martindale    Page : 1129   Edition : 37,
►  Side Effect : Somnolence, Dizziness, Mild asthenia, anxiety, fever, rhinitis, peripheral edema, constipation, dyspepsia, dry mouth, raised liver enzymes, Orthostatic hypotension, tachycardia, weight gain, syncope, leucopenia, neutropenia, eosinophilia, thrombocythaemia, rises in plasma-triglyceride, prolongation of the QT interval, reduced plasma- thyroid hormone concentrations, venous thromboembolism, Hyperglycaemia, preexisting diabetes, Neuroleptic malignant syndrome, seizure, hypersensitivity reactions, angioedema, priapism,
Ref :-   Book : Martindale    Page : 1128   Edition : 37,

►  Drug Interaction : Drug interaction of Quetiapine is with Phentolamine , Zonisamide , Levodopa , Erythromycin , Fluconazole , Itraconazole , Ketoconazole , Carbamazapine , Phenytoin , Thioridazine ,
Ref :-   Book : Martindale    Page : 1129   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  CYP3A4 is the main isoenzyme responsible for cytochrome P450-mediated metabolism of quetiapine and caution is advised when quetiapine is used with potent inhibitors of CYP3A4 such as erythromycin, fluconazole, itraconazole, and ketoconazole; lower doses of quetiapine should be used when given with such drugs. Conversely, enzyme inducers such as carbamazepine and phenytoin may decrease the plasma concentrations of quetiapine, and higher doses of quetiapine may be necessary. Thioridazine has also been reported to increase the clearance of quetiapine. ,
Ref :-   Book : Martindale    Page : 1129   Edition : 37,


►  Contraindication : Hypersensitivity,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 205   Edition : 3,
  ►  Mechanism of Action :   Combined antagonist properties at dopamine D2 and serotonin 5-HT2 receptors,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 205   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- 5 HTP(5-HYDROXYTRYPTOPHAN) with Cause anxiety,confusion & other side effect ., IODINE with Increase side effect,

  ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,

    ►   Route of Elimination :   Fecal, Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 1129   Edition : 37,


    ►    Plasma Half-life :   Min value :-   6 hours,    Max value :-   7 hours,
    Ref :-   Book : Martindale    Page : 1129   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   1.5 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1129   Edition : 37,