Quinidine is a Medicine belongs to Sodium channel blockers group whose information about Brand can be referenced from   Book : Martindale    Page : 1520   Edition : 37,

  ►   Brandname : Kinidin

  ►  Strength : Tablet with 200  mg, Tablet with 300  mg, Tablet with 324  mg, Injection with 80  mg/ml, Tablet with 275  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 249   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 1520   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Supraventricular arrhythmias IV infusion 250 micrograms/kg/min Injection
2 Ventricular arrhythmias IV infusion 250 micrograms/kg/min Injection

Ref :-  Book : Martindale    Page : 1520   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Arrhythmia Oral 30 60 mg/kg/day

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1611   Edition : 19,
►  Organ Affected Hematopoietic toxicity (Thrombocytopenia)  

Precaution :- If a Patient is using 'Quinidine' drug in  MYASTHENIA GRAVIS  disease, then Please Use with caution .

►  Side Effect : nausea, vomiting, diarrhea, hypersenstivity, pruritus, Skin rashes, purpura, thrombocytopenia, blood dyscrasias, lupus-like syndrome, tinnitus, visual disturbances, headache, Confusion, vertigo, abdominal pain, hypotension, torsade de pointes, fever, anaphylaxis, respiratory difficulties, granulamatous Hepatitis, impaired hearing, precipitate ventricular arrhythmias,
Ref :-   Book : Martindale    Page : 1518   Edition : 37,

►  Drug Interaction : Drug interaction of Quinidine is with Rifampicin , Phenobarbital , Phenytoin , Pioglitazone Hydrochloride , Potassium Permanganate , Corticotropin , ,
Ref :-   Book : Martindale    Page : 1519   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Quinidine is metabolised in the liver, mainly by the cytochrome P450 isoenzyme CYP3A4, and may interact with inhibitors or inducers of this isoenzyme. Rifampicin, phenobarbital, and phenytoin increase the metabolism of quinidine and increased doses may be required; HIV-protease inhibitors, which inhibit CYP3A4, may produce toxic concentrations of quinidine. Quinidine itself may also have effects on other drugs; it inhibits cytochrome P450 isoenzyme CYP2D6 and may affect drugs metabolised by this route. Examples of further drugs that may be affected by quinidine include oral anticoagulants, beta blockers, and digoxin; more details are given under the monographs for these drugs,
Ref :-   Book : Martindale    Page : 1519   Edition : 37,


►  Contraindication : heart block , heart failure, severe myocardial damage, myocarditis,
Ref :-   Book : Martindale    Page : 1519   Edition : 37,
  ►  Mechanism of Action :   Moderate block of voltage-gated Na+ channels in venticular myocytes (decreases phase 0 upstroke velocity and prolongs repolarization) and SA nodal cells (shifts threshold to more positive potentials and decreases slope of phase 4 depolarization); quinidine also blocks K+ channels that are opened upon vagal stimulation of muscarinic receptors in the AV node (vagolytic effect).,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 418   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Cincona bark with Another pathway,

  ►  Pathway with its reference as follows :-
  • quinine have Vasodilator activity --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- MAGNESIUM with Decrease in Nutrient Level, POTASSIUM with Decrease in Nutrient Level, SODIUM BICARBONATE with Dietary Substance is Drug Inhibitor, SENNA LEAVES with Dietary Substance is Drug Inhibitor,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf, http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf, https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- BELLABONNA with Increasing anticholinergic activity of tricyclic antidepressants ., BETACAROTENE with It reduce the side effect of drug ., SALT with High -salt diet had dramatically lower quinidine blood levels compared with people on a low salt diet ., VITAMIN K with Impairs vit K status .,

      ►  Reference :-
  • Duke, J. (2002). Handbook of Medicinal Herbs (2nd ed.). Boca Raton London New York Washington ,D.C.
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- http://www.crcnetbase.com/doi/pdf/10.1201/9781420040463.fmatt, http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 1519   Edition : 37,


    ►    Plasma Half-life :   Min value :-   6 hours,    Max value :-   8 hours,
    Ref :-   Book : Martindale    Page : 1519   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1519   Edition : 37,