Quinine is a Medicine belongs to antimalarial group whose information about Brand can be referenced from   Book : Martindale    Page : 669   Edition : 37,

  ►   Brandname : Cinkona,Quinarsol,Quininga,Qualaquin

  ►  Strength : Tablet with 260  mg, Capsule with 200  mg, Capsule with 260  mg, Capsule with 325  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 935   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, IM,
Reference :-   Book : Martindale    Page : 669   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Malaria Oral 600 mg Dose: Given: every 8 hours for 7 days.
2 Malaria IV infusion 20 mg/kg Injection Dose: Given every 4 hours.
3 Leg cramps Oral 200 300 mg Dose: Given at night.

Ref :-  Book : Martindale    Page : 668   Edition : 37, Martindale    Page : 669   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Uncomplicated falciparum malaria Oral 10 mg/kg
2 Uncomplicated falciparum malaria IV infusion 5 mg/kg/hour Injection

Ref :- Book : Martindale    Page : 669   Edition : 37,
►  Organ Affected Nephrotoxicity – (Thromobotic microangiopathy)  

Precaution :- If a Patient is using 'Quinine' drug in  MYASTHENIA GRAVIS  disease, then Please Use with caution .

Precaution :- If a Patient is using 'Quinine' drug in autoimmune hemolytic anemia disease, then Please Not to be given   if he ever suffered from Malaria disease.
Precaution :- If a Patient is using 'Quinine' drug in  acute kidney injury   disease, then Please to be avoided .

►  Side Effect : impaired hearing, tinnitus, headache, nausea, vomiting, abdominal pain, diarrhea, vertigo, fever, Skin rashes, dyspnoea, hypoglycemia, hypoprothrombinaemia, renal failure, Cinchonism, angioedema, haemoglobinuria,
Ref :-   Book : Martindale    Page : 666   Edition : 37,

►  Drug Interaction : Drug interaction of Quinine is with Halofantrine, Astemizole, Cisapride , Pimozide , Mefloquine ,
Ref :-   Book : Martindale    Page : 668   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  It has a curare-like action at the neuromuscular junction and depresses the muscle action potential. If given during recovery from neuromuscular block it can result in muscle weakness and apnoea and it should be avoided, if possible, in the immediate postoperative period. Halofantrine prolongs the QT interval ,
Ref :-   Book : Martindale    Page : 2067,657   Edition : 37,


►  Absolute Contraindication : History of hypersensitivity to quinine or quinidine and in patients with tinnitus or optic neuritis   haemolysis   myasthenia gravis.  

►  Contraindication : Hypersensitivity, Optic neuritis, haemolysis, myasthenia gravis, heart block , atrial fibrillation, cardiac conduction defects,
Ref :-   Book : Martindale    Page : 668   Edition : 37,
  ►  Mechanism of Action :   It may interfere with lysosome function or nucleic acid synthesis in the malaria parasite.,
Ref :-   Book : Martindale    Page : 668   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- with same pathway,

  ►  Pathway with its reference as follows :-
  • Anti-malerial property due to Quinine & quinidine --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- FOLATE with Impairs folate status.,

      ►  Reference :-
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 668   Edition : 37,


    ►    Plasma Half-life :   Min value :-   11 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 668   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   3 hours,
    Ref :-   Book : Martindale    Page : 668   Edition : 37,