Quinupristin/Dalfopristin is a Medicine belongs to STREPTOGRAMINS group whose information about Brand can be referenced from   Book : Martindale    Page : 348   Edition : 38,

  ►   Brandname : Synercid

  ►  Strength :

A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 351   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Antibacterial IV infusion 7.5 mg/kg Injection Dose: Given in glucose 5% over 60 minutes. dalfopristin 5.25 mg/kg) every 8 or 12 hours for at least 7 days.

Ref :-  Book : Martindale    Page : 347   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : nausea, vomiting, diarrhea, Skin rashes, pruritus, headache, Pain, myalgia, arthralgia, eosinophilia, anaemia, leucopenia, neutropenia, thrombocytopenia, pancytopenia, Pseudomembranous colitis, Hyperbilirubinaemia, raised liver enzyme values, pain and swelling at the site of injection, thrombophlebitis,
Ref :-   Book : Martindale    Page : 347   Edition : 38,

►  Drug Interaction : Drug interaction of Quinupristin/Dalfopristin is with Mycophenolate mofetil , Fosphenytoin , , Olmesartan medoxomil , Moxifloxacin , Epinephrine (adrenaline) , Chloroquine , Mefloquine , Quinine , , Fluoxetine , Imipramine , Venlafaxine , Astemizole, Cisapride , Terfenadine, Cyclosporine , Midazolam , Nifedipine , Tacrolimus , , Haloperidol , Risperidone/Respidon , Quetiapine ,
Ref :-   Book : Martindale    Page : 347   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Quinupristin/dalfopristin inhibits the cytochrome P450 isoenzyme CYP3A4 and it may therefore inhibit the metabolism of a number of drugs discussed as follows; In particular, there is a theoretical possibility of serious ventricular arrhythmias when given with drugs that prolong the QT interval, such as astemizole, cisapride, and terfenadine. Quinupristin/dalfopristin has been shown to increase plasma concentrations of ciclosporin, midazolam, nifedipine , and tacrolimus. The use of ergot alkaloids with quinupristin/ dalfopristin should be avoided. Some anticonvulsants (e.g., fosphenytoin and felbamate), macrolide antibiotics; some fluoroquinolones (e.g., moxifloxacin) and ketoconazole; some antimalarials (e.g., chloroquine, mefloquine, and quinine); some antidepressants (e.g., fluoxetine, imipramine, venlafaxine), some antipsychotics (e.g., haloperidol, risperidone, and quetiapine) and doxepin.,
Ref :-   Book : Goodman    Page : 1537   Edition : 12,


►  Contraindication : Hypersensitivity, hepatic impairment, hyperbilirubinaemia, Arrhythmia,
Ref :-   Book : Martindale    Page : 347   Edition : 38,
  ►  Mechanism of Action :   Quinupristin and dalfopristin are protein synthesis inhibitors that bind the 50S ribosomal subunit.,
Ref :-   Book : Goodman    Page : 1536   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Biliary, Renal,
Ref :-   Book : Martindale    Page : 351   Edition : 38,


►    Plasma Half-life :
  Min value :-   0.9 hours,    Max value :-   0.75 hours,
Ref :-   Book : Martindale    Page : 315   Edition : 38,

►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
Ref :-   Book :    Page :    Edition : ,