Rabeprazole is a Medicine belongs to Proton pump inhibitor group whose information about Brand can be referenced from   Book : Martindale    Page : 1920   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Odirab,Pariet,Rabelc, Rabicip,Rabefit DSR,Rapeed,Rapeed D,Cyra-D,Derek,Derek D,Drego-D,Normaxin RT

  ►  Strength : Delayed- release tablets with 20  Mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 1111   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1920   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Gastro-oesophageal reflux disease Oral 20 mg Tablet o.d. Dose: Given for 4 to 8 weeks; in the USA, a further 8-week course is permitted for healing of erosive oesophagitis. Thereafter, maintenance therapy can be continued with 10 or 20 mg daily depending on the response. For symptomatic disease without erosive or ulcerative oesophagitis a dose of 10 or 20 mg may be given once daily for 4 weeks; in the USA, a further 4-week course is permitted. Once symptoms have resolved, a dose of 10 mg once daily may be given as necessary
2 Peptic ulcer Oral 20 mg Tablet Dose: Given for 4 to 8 weeks.
3 Duodenal ulcer Oral 20 mg Tablet Dose: Given for 4 to 8 weeks.
4 Gastric ulcer Oral 20 mg Tablet Dose: Given for 6 to 12 weeks.
5 Zollinger-ellison syndrome Oral 60 mg Tablet o.d. Dose: adjusted according to response. Doses up to 120 mg daily have been given; when the daily dose is more than 100 mg it should be given in 2 divided doses.
6 Eradication of H. pylori Oral 20 mg Tablet b.d. Dose: combined with clarithromycin 500 mg twice daily and amoxicillin 1 g twice daily, or combined with clarithromycin 250 mg twice daily and metronidazole 400 mg twice daily.

Ref :-  Book : Martindale    Page : 1920   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : headache, diarrhoea, Skin rashes, pruritus, Dizziness, fatigue, constipation, nausea, vomiting, Flatulence, abdominal pain, arthralgia, myalgia, Urticaria, dry mouth, photosensitivity, bullous eruptions, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, hypersensitivity reactions, fever, bronchospasm, angioedema, anaphylaxis, insomnia, Somnolence, vertigo, Reversible confusional states, agitation, Depression, hallucinations, raised liver enzymes, hepatitis, jaundice, hepatic failure, Hepatic encephalopathy, ,
Ref :-   Book : Martindale    Page : 1906,1920   Edition : 37,

►  Drug Interaction : Drug interaction of Rabeprazole is with Diazepam , Phenytoin , Warfarin , Dasatinib, Ketoconazole , Itraconazole , Voriconazole , Atazanavir,
Ref :-   Book : Martindale    Page : 1908,1920   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Rabeprazole and other proton pump inhibitors are metabolised by the cytochrome P450 system, primarily by isoenzyme CYP2C19, and to a smaller extent by CYP3A4. Inhibitors or inducers of these isoenzymes may affect exposure to omeprazole and other proton pump inhibitors. In turn, proton pump inhibitors may alter the metabolism of some drugs metabolised by these enzymes. Rabeprazole may prolong the elimination of diazepam, phenytoin, and warfarin. Rabeprazole and other proton pump inhibitors can reduce the absorption of drugs such as dasatinib, ketoconazole, and itraconazole, whose absorption is dependent on an acid gastric pH. With voriconazole, the plasma concentration of both drugs may be increased. Other proton pump inhibitors may be similarly affected by voriconazole. Rabeprazole and other proton pump inhibitors should not be used with atazanavir, as it substantially reduces exposure to atazanavir.,
Ref :-   Book : Martindale    Page : 1908,1920   Edition : 37,


►  Contraindication : , hepatic impairment, Before giving omeprazole or other proton pump inhibitors to patients with gastric ulcers the possibility of malignancy should be excluded since these drugs may mask symptoms and delay diagnosis,
Ref :-   Book :    Page :    Edition : , Martindale    Page : 1908,1920   Edition : 37,
  ►  Mechanism of Action :   Rabeprazole is a proton pump inhibitor. It suppresses secretion of gastric acid by inhibiting the enzyme system of hydrogen/potassium adenosine triphosphatase (H+/K+ ATPase), the ‘proton pump’ of the gastric parietal cell.,
Ref :-   Book : Martindale    Page : 1908,1920   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- IRON with Dietary Substance is Drug Inhibitor,

  ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal, Faecal,
    Ref :-   Book : Martindale    Page : 1990   Edition : 37, Martindale    Page : 1920   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   3.5 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1920   Edition : 37,