Raltegravir is a Medicine belongs to Antiviral group whose information about Brand can be referenced from   Book : Martindale    Page : 997   Edition : 37,

  ►   Brandname : Isentress

  ►  Strength : Tablet with 400  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 889   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 997   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 HIV infection and AIDS Oral 400 mg Tablet b.d. Given with or withour food. Dose of raltegravir may need to be amended when given with rifampicin; a dose of 800 mg twice daily has been suggested.

Ref :-  Book : Martindale    Page : 997   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : rash, insomnia, abnormal dreams, headache, abdominal pain, diarrhoea, nausea, vomiting, asthenia, fatigue, Dizziness, vertigo, Psychiatric disturbances, anxiety, Depression, Paranoia, suicidal ideation, pre-existing history of mental illness, ,
Ref :-   Book : Martindale    Page : 997   Edition : 37,

►  Drug Interaction : Drug interaction of Raltegravir is with Rifampicin ,
Ref :-   Book : Martindale    Page : 997   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Raltegravir is not a substrate for cytochrome P450 isoenzymes, and does not appear to interact with drugs metabolised by this mechanism. However, rifampicin induces the glucuronidase responsible for raltegravir metabolism (UGT1A1) and reduces plasma concentrations of raltegravir; if use with rifampicin can not be avoided, increasing the dose of raltegravir may be considered ,
Ref :-   Book : Martindale    Page : 997   Edition : 37,


►  Contraindication : Abnormal creatine phosphokinase values may occur and myopathy and rhabdomyolysis have been reported although a causal relationship has not been established; nonetheless, caution is advised in patients at increased risk of these conditions. Increased liver transaminases and serum triglyceride concentrations may also occur,
Ref :-   Book : Martindale    Page : 997   Edition : 37,
  ►  Mechanism of Action :   Raltegravir is an inhibitor of HIV integrase, an enzyme essential for insertion of viral DNA into the host genome, and thus for replication.,
Ref :-   Book : Martindale    Page : 997   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Camphor tree with Another pathway,

  ►  Pathway with its reference as follows :-
  • Anti viral activaty due to active constituent menthol --- (18. PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 997   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   3 hour,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 997   Edition : 37,