Ranitidine is a Medicine belongs to H2 histamine receptor blockers group whose information about Brand can be referenced from   Book : Martindale    Page : 1922   Edition : 37,

  ►   Brandname : Ausran, Heartburn Relief, Rani 2, Junizac, Ran Lich, Rani, Rani-nerton, Aciloc, Consec, Histac, R-Loc, Rantac, Gavilast, Ranitic, Zantac

  ►  Strength : Tablet with 75  mg, Tablet with 150  mg, Tablet with 300  mg, Injection with 1  mg/ml, Injection with 25  mg/ml, Oral solution with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 1111   Edition : 12, Martindale    Page : 1922   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, IM,
Reference :-   Book : Martindale    Page : 1921   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Bening gastric and duodenal ulceration Oral 300 mg Tablet o.d. at bedtime or 150 mg twice daily (in the morning and at bedtime) is given initially for at least 4 weeks. Where appropriate a maintenance dose of 150 mg daily may be given at bedtime.
2 Ulcer associated with NSAID therapy Oral 150 mg Tablet b.d. 300 mg at bedtime may be given for 8 to 12 weeks; for duodenal ulcers, a higher dose of 300 mg twice daily for 4 weeks has also been used. (To prevent NSAID- associated ulcers, UK licenced product information recommends an oral dose of 150 mg twice daily given with NSAID treatment. A dose of 150 mg twice daily may be used to treat postoperative ulcer.
3 Duodenal ulcer associated with Helicobacter pylori infection Oral 300 mg Tablet o.d. Or 150 mg twice daily may be given as part of triple therapy with amoxicillin 750 mg and metronidazole 500 mg, both given orally, three times daily, for 2 weeks. Therapy with ranitidine should then be continued for a further 2 weeks.
4 Gastro-oesophageal reflux disease Oral 150 mg Tablet b.d. Or 300 mg at bedtime for up to 8 weeks or, if required, 12 weeks. This may be increased to 150 mg four times daily for up to 12 weeks in severe cases. In the maintenance of healing erosive oesophagitis, a dose of 150 mg twice daily may be used
5 Zollinger-ellison syndrome Oral 150 mg Tablet b.d/t.i.d Dose: may be increased if necessary; doses of up to 6 g daily have been used.
6 Zollinger-ellison syndrome IV infusion 1 mg/kg/hour Injection The rate may be increased by increments of 500 micrograms/kg per hour, beginning after 4 hours, if required. Intravenous doses upto 2.5 mg/kg/hour and infusion rates upto 220 mg/hour have been used.
7 Stress ulceration of the upper gastrointestinal tract slow i.v 50 mg Injection Followed by a continuous intravenous infusion of 125 to 250 micrograms/kg per hour.
8 Stress ulceration of the upper gastrointestinal tract Oral 150 mg Tablet b.d. May be given once oral feeding is resumed
9 Acid aspiration syndrome during general anaesthesia Oral 150 mg Tablet May be given 2 hours before the induction of anaesthesia and preferably also 150 mg the previous evening.
10 Acid aspiration syndrome during general anaesthesia IM or Slow IV 50 mg Injection Dose: May be given 45 to 60 minutes before the induction of anaesthesia. In obstetric patients, at the start of labour an oral dose of 150 mg may be given and may be repeated at intervals of 6 hours if required.
11 Chronic episodic dyspepsia Oral 150 mg Tablet b.d. For up to 6 weeks may be given. For the short-term symptomatic relief of dyspepsia a dose of 75 mg, repeated if necessary up to a maximum of 4 doses daily, may be taken. Treatment should be restricted to a maximum of 2 weeks of continuous use at one time.

Ref :-  Book : Martindale    Page : 1921   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Duodenal and gastric ulcers Oral 4 8 mg/kg
2 Gastro-oesophageal reflux disease Oral 5 10 mg/kg
3 Prevent stress ulceration in critically ill patients 3 Year 12 Year
4 Prevent stress ulceration in critically ill patients Oral 2 mg/kg t.i.d.
5 Prevent stress ulceration in critically ill patients 1 Month 6 Month Oral 1 mg/kg t.i.d.
6 Prevent stress ulceration in critically ill patients 6 Month 3 Year Oral 2 4 mg/kg
7 Peptic ulcer and gastro-oesophageal reflux disease 6 Month 11 Year Slow IV 2 2.5 mg/kg Injection
8 Prophylaxis of stress ulceration Slow IV 1 mg/kg Injection
9 Prevent stress ulceration in critically ill patients Slow IV Injection
10 Prevent stress ulceration in critically ill patients 1 Month 18 Year Slow IV 1 mg/kg Injection

Ref :- Book : Martindale    Page : 1922   Edition : 37,
Precaution :- If a Patient is using 'Ranitidine' drug in PEPTIC ULCER DISEASE disease, then Please use with caution with phenytoin   if he ever suffered from Epilapsy disease.
►  Side Effect : diarrhoea, Gastrointestinal disturbances, Dizziness, Tiredness, headache, myalgia, arthralgia, ,
Ref :-   Book : Martindale    Page : 1866,1921   Edition : 37,

►  Drug Interaction : Drug interaction of Ranitidine is with , bigunide/antidiabetic drug , ,  Lidocaine , Dasatinib, Ketoconazole , Itraconazole , Posaconazole , Dofetilide , Procainamide , Phenytoin , Carbamazapine , Moclobemide , Nifedipine , Carmustine , Sildenafil , Theophylline , Amitriptyline , Warfarin , Zalcitabine, Zolmitriptan ,
Ref :-   Book : Martindale    Page : 1868,1869,1921   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Ranitidine and other H2-antagonists can reduce the absorption of drugs such as dasatinib, ketoconazole, and possibly itraconazole, whose absorption is dependent on an acid gastric pH. Ranitidine may inhibit the hepatic metabolism of many drugs by binding to cytochrome P450 isoenzymes. Antiepileptics such as phenytoin, carbamazepine, Biguanide antidiabetics , Lidocaine , Nifedipine, opioid analgesics, procainamide , theophylline , tricyclic antidepressants such as amitriptyline , Warfarin and other oral anticoagulants, zalcitabine , zolmitriptan , Combinations of these drugs and cimetidine should be avoided or used with caution, with monitoring of effects or plasma-drug concentrations and reductions in dosage as appropriate.,
Ref :-   Book : Martindale    Page : 1868,1869,1921   Edition : 37,


►  Contraindication : renal impairment, Rapid intravenous injection should be avoided as there have been rare associations with cardiac arrest and arrhythmias; transient hypotension has also been seen.,
Ref :-   Book : Martindale    Page : 1866,1868,1921   Edition : 37,
  ►  Mechanism of Action :   The H2 receptor antagonists inhibit acid production by reversibly competing with histamine for binding to H2 receptors on the basolateral membrane of parietal cells.,
Ref :-   Book : Goodman    Page : 1313   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Banana with Another pathway, Strawberry with Another pathway, Strawberry with Another pathway,

  ►  Pathway with its reference as follows :-
  • Gallic acid found in banana have antiulcer property . --- ( Asokkumar, K., Sen, S., Umamaheswari, M., Sivashanmugam, A., & Subhadradevi, V. (2014). Synergistic effect of the combination of gallic acid and famotidine in protection of rat gastric mucosa. Pharmacological Reports, 66(4), 594-599. http://dx.doi.org/10.1016/j.pharep.2014.01.006 )
  • strawberry contain gallic acid which have antiulcer effect . --- (Sen, S. (2013). Antiulcerogenic Effect of Gallic Acid in Rats and its Effect on Oxidant and Antioxidant Parameters in Stomach Tissue. Indian Journal Of Pharmacuticle Science, 75(2), 149–155. Retrieved from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757852/ )
  • Ant- acid effect due to menthol --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757852/, http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- IRON with Dietary Substance is Drug Inhibitor,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Faecal, Renal,
    Ref :-   Book : Martindale    Page : 1921   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   3 hours,
    Ref :-   Book : Martindale    Page : 1921   Edition : 37,