Repaglinide is a Medicine belongs to Antidiabetic group whose information about Brand can be referenced from   Book : Martindale    Page : 498   Edition : 37,

  ►   Brandname : Rapilin,Prandin,NovoNorm

  ►  Strength : Tablet with 0.5  mg, Tablet with 1  mg, Tablet with 2  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 766   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 766   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Type 2 diabetes mellitus Oral 500 mcg Tablet Repaglinide is given up to 30 minutes before meals, and usually within 15 minutes. Initial doses of 1 or 2 mg are given to patients who have had previous hypoglycaemic treatment. The dose may be adjusted, at intervals of 1 to 2 weeks, up to amaximum of 4 mg before meals; a total of 16 mg daily should not be exceeded. Repaglinide is also given with metformin or a thiazolidinedione in type 2 diabetes not adequately controlled by monotherapy. The maximum recommended daily doses of Repaglinide is 10 mg.

Ref :-  Book : Martindale    Page : 496   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : abdominal pain, diarrhoea, constipation, nausea, vomiting, hypoglycemia, back pain, joint pains, ,
Ref :-   Book : Martindale    Page : 496   Edition : 37,

►  Drug Interaction : Drug interaction of Repaglinide is with Gemfibrozil , ,
Ref :-   Book : Martindale    Page : 497   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Drugs that affect the cytochrome P450 isoenzymes CYP2C8 and CYP3A4 may alter the metabolism of repaglinide. Use of repaglinide with the CYP2C8 inhibitor gemfibrozil has resulted in marked reduction in repaglinide clearance, and severe hypoglycaemia. Repaglinide also appears to be substrate for active hepatic uptake by the organic anion transporting protein OATP1B1, and may be affected by drugs that have the potential for its inhibition.,
Ref :-   Book : Martindale    Page : 497   Edition : 37,


►  Contraindication : hepatic impairment,
Ref :-   Book : Martindale    Page : 496   Edition : 37,
  ►  Mechanism of Action :   Repaglinide is a meglitinide antidiabetic that inhibit the beta cell K + /ATP channel at the SUR1 subunit thereby stiimulating insulin release from pancreatic beta cell and increasing circulating insulin to levels sufficient to overcome insulin resistance,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 538   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- ST JOHNS WORT with Dietary Substance is Drug Inhibitor,

  ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Biliary,
    Ref :-   Book : Martindale    Page : 497   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   1 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 497   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 497   Edition : 37,