Reteplase is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1486   Edition : 38,

  ►   Brandname : Rapilysin,Retavase

  ►  Strength : Injection with 10.4  IU,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 617   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 1486   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Myocardial infarction slow i.v 10 units Injection Dose: (but over not more than 2 minutes), and this dose of 10 units is repeated once, 30 minutes after the start of the first injection.

Ref :-  Book : Martindale    Page : 1486   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : haemorrhage, particularly from puncture sites; severe internal bleeding has occurred and may be difficult to control, Rashes, fever, chills, back pain, abdominal pain, nausea, vomiting, Few reports of Guillain-Barré syndrome, hypotension, bradycardia, Arrhythmias, The break-up of existing clots may occasionally produce emboli elsewhere; pulmonary embolism and acute renal failure due to cholesterol embolisation have been reported, ,
Ref :-   Book : Martindale    Page : 1486,1505   Edition : 37, Martindale    Page : 1486,1505    Edition : 37,

►  Drug Interaction : Drug interaction of Reteplase is with Oral anticoagulants,  Heparin , Aspirin, Dextran,
Ref :-   Book : Martindale    Page : 1486,1507   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Oral anticoagulants, heparin, and antiplatelet drugs such as aspirin are often used with it, but may increase the risk of haemorrhage. The risk may also be increased with dextrans, and with other drugs that affect coagulation or platelet function.,
Ref :-   Book : Martindale    Page : 1486,1507   Edition : 38,


►  Contraindication : It should be used with great care, if at all, in patients at increased risk of bleeding, or those in whom haemorrhage is likely to prove particularly dangerous, It should thus be avoided in patients with active internal bleeding or a recent history of peptic ulcer disease, oesophageal varices, ulcerative colitis or other bleeding gastrointestinal lesions, pancreatitis, subacute bacterial endocarditis, In patients with coagulation defects including those due to liver or kidney disease, or after recent surgery, childbirth, or trauma, should not be given to patients at increased risk of cerebral bleeding including those with severe hypertension, haemorrhage or recent stroke, or to patients with cerebral neoplasm, It should not be given in pregnancy,
Ref :-   Book : Martindale    Page : 1486,1507   Edition : 37,
  ►  Mechanism of Action :   Reteplase is a thrombolytic drug. It converts plasminogen to plasmin, resulting in fibrinolysis and dissolution of clots.,
Ref :-   Book : Martindale    Page : 1486   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   NA


►    Plasma Half-life :
  Min value :-   NA    Max value :-   NA


►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA