Ribavirin is a Medicine belongs to Antiviral group whose information about Brand can be referenced from   Book : Martindale    Page : 999   Edition : 37  

  ►   Brandname : Virazide, Copegus, Rebetol, Virazole, Ribavin, Copegus, Rebetol, RibaPak
  ►  Strength : Aerosol with 6/100 gm/ml.  Capsule with 200 mg.  Tablet with 200 mg.  Solution with 40 mg/ml.  Nebuliser Solution with .  Inhalation Solution with

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 889   Edition : 12   Martindale    Page : 999   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, inhalation
Reference :-   Book : Martindale    Page : 998   Edition : 37   Martindale    Page : 999   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Hepatitis C inhalation 400 mg Inhalant Dose given in morning and 600 mg in the evening.

Ref :-  Book : Martindale    Page : 998   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Hepatitis C inhalation 15 mg/kg Inhalant

Ref :- Book : Martindale    Page : 998   Edition : 37  
►  Side Effect : When given by inhalation, ribavirin has sometimes led to worsening of lung function, bacterial pneumonia, and pneumothorax, to cardiovascular effects (including a fall in blood pressure and cardiac arrest), The most common adverse effects reported by patients taking oral ribavirin, with either interferon alfa or peginterferon alfa, are psychiatric reactions (such as anxiety, depression, insomnia, and irritability) and flulike symptoms., Severe adverse effects include haemolytic anaemia, leucopenia, thrombocytopenia, aplastic anaemia, diabetes mellitus, auto-immune disorders, gastrointestinal symptoms, pancreatitis, pulmonary embolism, chest pain, liver dysfunction, interstitial pneumonitis
Ref :-   Book : Martindale    Page : 997   Edition : 37.  

►  Drug Interaction : Drug interaction of Ribavirin is with Zidovudine, Lamivudine, Stavudine, Didanosine
Ref :-   Book : Martindale    Page : 998   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  Ribavirin with zidovudine is not recommended as patients are at increased risk of anaemia. Increased toxicity has also been seen with didanosine, and the combination should be avoided. Ribavirin inhibits the phosphorylation of NRTIs such as zidovudine, lamivudine, and stavudine.
Ref :-   Book : Martindale    Page : 998   Edition : 37.  

►  Contraindication : Standard supportive respiratory and fluid management should be maintained during aerosol treatment with ribavirin and electrolytes should be monitored closely., Ribavirin should not be given orally to patients with pre-existing medical conditions that could be exacerbated by ribavirin- induced haemolysis, including significant or unstable cardiac disease or haemoglobinopathies (thalassaemia or sickle-cell anaemia)., Patients with renal impairment and a creatinine clearance of less than 50 mL/minute should not receive oral ribavirin. It should be avoided in patients with severe hepatic impairment or decompensated cirrhosis of the liver (Child-Pugh 6 or more)., The potential for development of gout should be considered in predisposed patients. Patients should be monitored for signs and symptoms of psychiatric disorders., The growth of children should be monitored and thyroid function should be tested every 3 months. Patients infected with hepatitis C virus and HIV should be carefully monitored for signs of mitochondrial toxicity and lactic acidosis.
Ref :-   Book : Martindale    Page : 997-998   Edition : 37.  
  ►  Mechanism of Action :   The antiviral mechanism of ribavirin is incompletely understood but relates to alteration of cellular nucleotide pools and inhibition of viral messenger RNA synthesis
Ref :-   Book : Goodman    Page : 1613   Edition : 12.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- Lumra with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Isochlorogenic acid A have antiviral effect --- ( Lin, L., Hsu, W., & Lin, C. (2014). Antiviral Natural Products and Herbal Medicines. Journal Of Traditional And Complementary Medicine, 4(1), 24-35. http://dx.doi.org/10.4103/2225-4110.124335 )

  •   ►  URL --
  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032839/ .

  • DIETARY Substance Interactions

    ​   ► This Medicine interact with :- NA

    ContraIndication DIETARY Substance

    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal
    Ref :-   Book : Martindale    Page : 998   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   9.5 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 998   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2 hours.  
    Ref :-   Book : Martindale    Page : 998   Edition : 37.