Rifabutin is a Medicine belongs to Antitubercular Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 353   Edition : 37  

  ►   Brandname : Mycobutin
  ►  Strength : Capsule with 150 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 848   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 353   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Prophylaxis of MAC infection Oral 300 mg Capsule Dose: given daily.
2 Nontuberculous mycobacterial infections Oral 450 600 mg Capsule Dose: Given daily in a multidrug regimen for up to 6 months after negative cultures are obtained.
3 Pulmonary tuberculosis Oral 300 mg Capsule Dose: Given daily daily for at least 6 months as part of a multidrug regimen; it can also be given intermittently (usually 3 times each week) as an alternative to daily use.

Ref :-  Book : Martindale    Page : 353   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Prophylaxis of MAC infection 6 Year Oral 5 mg/kg Capsule
2 Nontuberculous mycobacterial disease 1 Month 12 Year Oral 5 mg/kg Capsule o.d.
3 Tuberculosis 12 Year Oral 150 450 mg Capsule o.d.

Ref :- Book : Martindale    Page : 353   Edition : 37  
►  Side Effect : Rashes, Gastrointestinal disturbances, Neutropenia, Facial flushing and itching, with or without a rash, A flu-like syndrome characterised by episodes of fever, chills, headache, dizziness, bone pain, shortness of breath, and malaise, Nausea, Vomiting, Anorexia, Diarrhoea, Epigastric distress, Pseudomembranous colitis, Transient abnormalities in liver function, Hepatitis, Fatalities due to hepatotoxicity have been reported occasionally, Eosinophilia, leucopenia, Haemolytic anaemia, Alterations in kidney function and renal failure have occurred, particularly during intermittent therapy., Menstrual disturbances, Headache, Drowsiness, Ataxia, Dizziness, Numbness, Oedema, Myopathy, Muscular weakness, Thrombophlebitis, Local irritation, Inflammation, It causes a harmless orange-red discoloration of the urine, faeces, sweat, saliva, sputum, tears, and other body fluids.
Ref :-   Book : Martindale    Page : 352,354   Edition : 37.  

►  Drug Interaction : Drug interaction of Rifabutin is with MACROLIDES ,  Clarithromycin , Fluconazole
Ref :-   Book : Martindale    Page : 352   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  Rifabutin accelerates the metabolism of many drugs by inducing microsomal liver enzymes (in particular the cytochrome P450 isoenzyme CYP3A4). It is a less potent inducer of cytochrome P450 isoenzymes than rifampicin, but similar interactions should nevertheless be anticipated. Use with other drugs that induce or inhibit these isoenzymes may result in changes in plasma concentrations of rifabutin, and possibly adverse effects. Plasma concentrations of rifabutin are increased by clarithromycin (and possibly other macrolides) or fluconazole, resulting in increased rifabutin toxicity, in particular uveitis, neutropenia, and polyarthralgia-arthritis syndrome.
Ref :-   Book : Martindale    Page : 352   Edition : 37.  

►  Contraindication : Severe hepatic impairment, Severe renal impairment, Thrombocytopenia, Purpura, jaundice, Liver function should be checked before treatment with rifampicin and special care should be taken in alcoholic patients or those with pre-existing liver disease who require regular monitoring during therapy., Risperidone should be used with caution in patients with cardiovascular disease, including conditions associated with QT prolongation, or conditions predisposing to hypotension.
Ref :-   Book : Martindale    Page : 352,353   Edition : 37.  
  ►  Mechanism of Action :   Rifabutin enters bacilli in a concentration dependent manner, achieving steady-state concentrations within 15 minutes. Rifabutin binds to the subunit of DNA-dependent RNA polymerase (rpoB) to form a stable drug–enzyme complex. Drug binding suppresses chain formation in RNA synthesis.
Ref :-   Book : Goodman    Page : 1550   Edition : 12.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism), Renal, Faecal
Ref :-   Book : Martindale    Page : 353   Edition : 37.  

►    Plasma Half-life :   Min value :-   32 hours,    Max value :-   67 hours.  
Ref :-   Book : Goodman    Page : 1553   Edition : 12.  

►    Peak Plasma Concentration :   Min value :-   2.5 hours,    Max value :-   4 hours.  
Ref :-   Book : Goodman    Page : 1553   Edition : 12.