Rifampicin is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book :    Page :   Edition : , Martindale    Page : 357   Edition : 37,

  ►   Brandname : Akurit 4,AKT-3,Rifadin, Rimycin, Eremfat, Rifa, R-Cin, Rifacilin, Rifadin, Rimactane

  ►  Strength : Capsule with 150  mg, Capsule with 300  mg, Injection with 600  mg, Tablet with   , Oral Suspension with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 848   Edition : 12, Martindale    Page : 357   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 356-357   Edition : 37, Martindale    Page : 356-357   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Tuberculosis Oral 8 12 mg/kg ( to a maximum of 600 mg) daily, preferably on an empty stomach, or the same dose by intravenous infusion as the base or the sodium salt; higher doses are sometime used
2 Tuberculosis test
3 Latent tuberculosis Oral 10 mg/kg (to a maximum dose of 600 mg) may be given once daily with isoniazid for 3 months. If the contact is infected with isoniazid-resistant tuberculosis then rifampicin monotherapy may be given daily for 4 to 6 months.
4 Leprosy Oral 600 mg Rifampicin is usually given with dapsone for paucibacillary leprosy, and with dapsone and clofazimine for multibacillary leprosy. Singledose treatment with rifampicin, ofloxacin, and minocycline may be an alternative in patients with single-lesion paucibacillary leprosy.
5 Brucellosis, Legionnaires’ disease, and serious staphylococcal infections 600 1200 mg Dose given daily, orally or by intravenous infusion, in divided doses has been recommended in combination with other antibacterials.
6 Prophylaxis against meningococcal meningitis and the treatment of meningococcal carriers Oral 600 mg b.d. Dose given daily for 2 days
7 Prophylaxis against meningitis due to Haemophilus influenzae Oral 20 mg/kg o.d. (to a maximum dose of 600 mg daily) for 4 days is given to adults

Ref :-  Book : Martindale    Page : 356,357   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Tuberculosis Oral 20 mg/kg
2 Tuberculosis 1 Month Oral 10 mg/kg o.d.
3 Latent tuberculosis 1 Month Oral 10 mg/kg
4 Leprosy 10 Year Oral 450 mg
5 Brucellosis, Legionnaires’ disease, and serious staphylococcal infections 5 10 mg/kg b.d.
6 Prophylaxis against meningococcal meningitis 1 Month Oral 5 mg/kg
7 Prophylaxis against meningococcal meningitis 5 mg/kg
8 Prophylaxis against meningococcal meningitis 1 Year 12 Year Oral 10 mg/kg
9 Prophylaxis against meningitis due to Haemophilus influenzae Oral 10 mg/kg
10 Prophylaxis against meningitis due to Haemophilus influenzae Oral 20 mg/kg

Ref :- Book : Martindale    Page : 357   Edition : 37,
Precaution :- If a Patient is using 'Rifampicin' drug in  TUBERCULOSIS  disease, then Please contraindications- Hypersensitivity to rifamycins. .

Precaution :- If a Patient is using 'Rifampicin' drug in  TUBERCULOSIS  disease, then Please Contraindicated in patients receiving Ritonavir boosted saquinavir, because of increased risk of severe hepatocellular toxicity. .

Precaution :- If a Patient is using 'Rifampicin' drug in  TUBERCULOSIS  disease, then Please Contraindicated in patients receiving atazanavir, darunavir, fosamprenavir, saquinavir, or tipranavir, because rifampin may cause substantial decreases in plasma concentrations of these antiviral drugs, which may result in loss of antiviral efficacy or de .

Precaution :- If a Patient is using 'Rifampicin' drug in  TUBERCULOSIS  disease, then Please Cautions: May decrease the effectiveness of oral contraceptive pills (OCPs) Do not administer parenteral preparation IM or SC Patients on regimens of >600 mg once or twice weekly may experience adverse reactions, including flu like syndrome. .

Precaution :- If a Patient is using 'Rifampicin' drug in  TUBERCULOSIS  disease, then Please Cautions: Discontinue therapy if patient develops any signs of hepatocellular damage, including hyperbilirubinemia Prolonged use may result in bacterial or fungal superinfection Use with caution in patients with liver impairment and porphyria Not for .

Precaution :- If a Patient is using 'Rifampicin' drug in  ACUTE VIRAL HEPATITIS  disease, then Please Avoid .

Precaution :- If a Patient is using 'Rifampicin' drug in  thallasemia  disease, then Please Avoid .

►  Side Effect : facial flushing and itching, with or without a rash, A flu-like syndrome characterised by episodes of fever, chills, headache, dizziness, bone pain, shortness of breath, and malaise, nausea, vomiting, anorexia, diarrhoea, epigastric distress, Pseudomembranous colitis, Transient abnormalities in liver function, hepatitis, Fatalities due to hepatotoxicity have been reported occasionally, eosinophilia, leucopenia, haemolytic anaemia, Alterations in kidney function and renal failure have occurred, particularly during intermittent therapy., menstrual disturbances, headache, drowsiness, ataxia, Dizziness, Numbness, oedema, myopathy, muscular weakness, thrombophlebitis, local irritation, inflammation, It causes a harmless orange-red discoloration of the urine, faeces, sweat, saliva, sputum, tears, and other body fluids., ,
Ref :-   Book : Martindale    Page : 354   Edition : 37,

►  Drug Interaction : Drug interaction of Rifampicin is with oral contraceptives,  Isoniazid , Halothane , Atovaquone ,
Ref :-   Book : Martindale    Page : 355   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Rifampicin accelerates the metabolism of many drugs by inducing microsomal liver enzymes (in particular the cytochrome P450 isoenzyme CYP3A) or drug transporter proteins (such as p-glycoprotein). Drugs so affected may require an increase in dosage to maintain effectiveness and patients should be monitored closely when starting or stopping concurrent rifampicin treatment. Women taking oral contraceptives should use additional precautions or change to a non-hormonal form of contraception. The absorption of rifampicin may be reduced by antacids, but this interaction can be overcome by giving rifampicin 1 hour before any antacids. Similarly, rifampicin and preparations containing bentonite (for example some aminosalicylic acid preparations) should be given 8 hours apart. Isoniazid and halothane may increase the potential for hepatotoxicity when given with rifampicin. Atovaquone may increase the concentration of rifampicin, while rifampicin decreases. the concentration of atovaquone.,
Ref :-   Book : Martindale    Page : 355   Edition : 37,


►  Contraindication : thrombocytopenia, Purpura, hepatic impairment, jaundice, Liver function should be checked before treatment with rifampicin and special care should be taken in alcoholic patients or those with pre-existing liver disease who require regular monitoring during therapy., Risperidone should be used with caution in patients with cardiovascular disease, including conditions associated with QT prolongation, or conditions predisposing to hypotension.,
Ref :-   Book : Martindale    Page : 355   Edition : 37,
  ►  Mechanism of Action :   Rifampin binds to the β subunit of bacterial DNA-dependent RNA polymerase and thereby inhibits RNA synthesis,
Ref :-   Book : Basic & Clinical pharmacology    Page : 841   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Wood sage with Another pathway, Wood sage with Another pathway,

  ►  Pathway with its reference as follows :-
  • Isoquinoline Alkaloid have antitubercular effect --- (Pdr For Herbal Medicine. 4th ed. 2016. Print. )
  • Anti tubercular --- (18. PDR for Herbal medicines. (2000) (4th ed.). U.S. )
  • Isoquinoline Alkaloid have antitubercular effect --- (Pdr For Herbal Medicine. 4th ed. 2016. Print. )
  • Anti tubercular --- (18. PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Faecal, Renal, Biliary, Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 356   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   2 hours,    Max value :-   5 hours,
    Ref :-   Book : Goodman    Page : 1553   Edition : 12,

    ►    Peak Plasma Concentration :   Min value :-   1.5 hours,    Max value :-   2 hours,
    Ref :-   Book : Goodman    Page : 1553   Edition : 12,