Rifapentine is a Medicine belongs to Antitubercular Drugs group whose information about Brand can be referenced from   Book : Basic & Clinical pharmacology    Page : 848   Edition : 12  

  ►   Brandname : Priftin
  ►  Strength : Tablet with 150 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 848   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 358   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Tuberculosis Oral 600 mg Tablet Dose: Given twice weekly during the initial intensive phase of short-course tuberculosis regimens, then once weekly during the continuation phase.

Ref :-  Book : Martindale    Page : 358   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Facial flushing and itching, with or without a rash, A flu-like syndrome characterised by episodes of fever, chills, headache, dizziness, bone pain, shortness of breath, and malaise, Nausea, Vomiting, Anorexia, Diarrhoea, Epigastric distress, Pseudomembranous colitis, Transient abnormalities in liver function, Hepatitis, Fatalities due to hepatotoxicity have been reported occasionally, Eosinophilia, leucopenia, Hemolytic anemia, Alterations in kidney function and renal failure have occurred, particularly during intermittent therapy., Menstrual disturbances, Headache, Drowsiness, Ataxia, Dizziness, Numbness, Oedema, Myopathy, Muscular weakness, Thrombophlebitis, Local irritation, Inflammation, It causes a harmless orange-red discoloration of the urine, faeces, sweat, saliva, sputum, tears, and other body fluids., , Hyperuricaemia
Ref :-   Book : Martindale    Page : 354,358   Edition : 37.  

►  Drug Interaction : Drug interaction of Rifapentine is with oral contraceptives,  Isoniazid , Halothane , Atovaquone
Ref :-   Book : Martindale    Page : 355,358   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  Enzyme induction studies have suggested that rifapentine is a more potent inducer of cytochrome P450 isoenzymes than rifabutin, but less potent then rifampicin. Rifapentine accelerates the metabolism of many drugs by inducing microsomal liver enzymes (in particular the cytochrome P450 isoenzyme CYP3A) or drug transporter proteins (such as p-glycoprotein). Drugs so affected may require an increase in dosage to maintain effectiveness and patients should be monitored closely when starting or stopping concurrent rifapentine treatment. Women taking oral contraceptives should use additional precautions or change to a non-hormonal form of contraception. The absorption of rifapentine may be reduced by antacids, but this interaction can be overcome by giving rifampicin an hour before any antacids. Similarly, rifapentine and preparations containing bentonite (for example some aminosalicylic acid preparations) should be given 8 hours apart. Isoniazid and halothane may increase the potential for hepatotoxicity when given with rifapentine. Atovaquone may increase the concentration of rifapentine, while rifapentine decreases. the concentration of atovaquone.
Ref :-   Book : Martindale    Page : 355,358   Edition : 37.  

►  Contraindication : Rifapentine is only licensed for use in once- or twice-weekly regimens, and should not be given to HIV-infected patients because of potential interactions with HIV-protease inhibitors; an increased risk of developing resistance to rifamycins with highly intermittent (once- or twice-weekly) dosing regimens may occur in these patient, Thrombocytopenia, Purpura, Hepatic impairment, jaundice, Liver function should be checked before treatment with rifampicin and special care should be taken in alcoholic patients or those with pre-existing liver disease who require regular monitoring during therapy., Risperidone should be used with caution in patients with cardiovascular disease, including conditions associated with QT prolongation, or conditions predisposing to hypotension.
Ref :-   Book : Martindale    Page : 355,358   Edition : 37.  
  ►  Mechanism of Action :   Inhibits DNA-dependent RNA polymerase, thereby blocking production of RNA.
Ref :-   Book : Basic & Clinical pharmacology    Page : 847   Edition : 12.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Fecal, Renal
Ref :-   Book : Martindale    Page : 358   Edition : 37.  

►    Plasma Half-life :   Min value :-   13 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 358   Edition : 37.  

►    Peak Plasma Concentration :   Min value :-   5 hours,    Max value :-   6 hours.  
Ref :-   Book : Martindale    Page : 358   Edition : 37.