Rifaximin is a Medicine belongs to Antitubercular Drugs group whose information about Brand can be referenced from   Book : Basic & Clinical pharmacology    Page : 848   Edition : 12,

  ►   Brandname : Xifaxan

  ►  Strength : Tablet with 200  mg, Tablet with 550  mg, Ointment with 5  %,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 848   Edition : 12, Martindale    Page : 358   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Topical,
Reference :-   Book : Martindale    Page : 358   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Travellers diarrhoea Oral 200 mg Tablet t.i.d. Dose: For 12 year of age and older. for three days.
2 Overt hepatic encephalopathy Oral 550 mg Tablet b.d. Dose; For 18 years of age and older. Dose given for other indications range from 400 to 1200 mg daily, in 2 to 4 divided doses.

Ref :-  Book : Martindale    Page : 358   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : hypersensitivity reactions, exfoliative dermatitis, angioneurotic oedema, facial flushing, A flu-like syndrome characterised by episodes of fever, chills, headache, dizziness, bone pain, shortness of breath, and malaise, nausea, vomiting, anorexia, diarrhoea, epigastric distress, Pseudomembranous colitis, Transient abnormalities in liver function, hepatitis, Fatalities due to hepatotoxicity have been reported occasionally, eosinophilia, leucopenia, haemolytic anaemia, Alterations in kidney function and renal failure have occurred, particularly during intermittent therapy., menstrual disturbances, headache, drowsiness, ataxia, Dizziness, Numbness, oedema, myopathy, muscle weakness, thrombophlebitis, local irritation, inflammation, It causes a harmless orange-red discoloration of the urine, faeces, sweat, saliva, sputum, tears, and other body fluids., ,
Ref :-   Book : Martindale    Page : 354,358   Edition : 37,

►  Drug Interaction : Drug interaction of Rifaximin is with oral contraceptives,  Isoniazid , Halothane , Atovaquone ,
Ref :-   Book : Martindale    Page : 355,358   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Rifaximin accelerates the metabolism of many drugs by inducing microsomal liver enzymes (in particular the cytochrome P450 isoenzyme CYP3A) or drug transporter proteins (such as p-glycoprotein). Drugs so affected may require an increase in dosage to maintain effectiveness and patients should be monitored closely when starting or stopping concurrent rifaximin treatment. Women taking oral contraceptives should use additional precautions or change to a non-hormonal form of contraception. The absorption of rifaximin may be reduced by antacids, but this interaction can be overcome by giving rifaximin 1 hour before any antacids. Similarly, rifaximin and preparations containing bentonite (for example some aminosalicylic acid preparations) should be given 8 hours apart. Isoniazid and halothane may increase the potential for hepatotoxicity when given with rifaximin. Atovaquone may increase the concentration of rifaximin, while rifaximin decreases. the concentration of atovaquone.,
Ref :-   Book : Martindale    Page : 355,358   Edition : 37,


►  Contraindication : thrombocytopenia, Purpura, hepatic impairment, jaundice, Liver function should be checked before treatment with rifampicin and special care should be taken in alcoholic patients or those with pre-existing liver disease who require regular monitoring during therapy., Risperidone should be used with caution in patients with cardiovascular disease, including conditions associated with QT prolongation, or conditions predisposing to hypotension.,
Ref :-   Book : Martindale    Page : 355,358   Edition : 37,
  ►  Mechanism of Action :   Rifaximin is a rifampin derivative. Inhibits DNA-dependent RNA polymerase, thereby blocking production of RNA,
Ref :-   Book : Basic & Clinical pharmacology    Page : 847   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Knotweed with Another pathway,

  ►  Pathway with its reference as follows :-
  • Flavonoids have antitubercular property --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   NA


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA