Riluzole is a Medicine belongs to Muscle relaxants group whose information about Brand can be referenced from   Book : Martindale    Page : 2614   Edition : 37,

  ►   Brandname : Rilutek

  ►  Strength : Tablet with 50  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 481   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 2614   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Amyotrophic lateral sclerosis Oral 50 mg Tablet b.d. Dose: Given on an empty stomach.

Ref :-  Book : Martindale    Page : 2614   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : asthenia, nausea, Elevations in liver enzymes values, headache, abdominal pain, diarrhoea, constipation, anorexia, vomiting, tachycardia, Dizziness, vertigo, Somnolence, Circumoral paraesthesia, rhinitis, Lung function may be decreased and case of interstitial lung disease, some time severe, have been reported, ,
Ref :-   Book : Martindale    Page : 2613   Edition : 37,

►  Drug Interaction : Drug interaction of Riluzole is with NA

  ►    Mechanism of Drug Drug Interaction :  ,
Ref :-   Book :    Page :    Edition : ,


►  Contraindication : hepatic disease, raised liver enzyme values, renal impairment,
Ref :-   Book : Martindale    Page : 2613   Edition : 37,
  ►  Mechanism of Action :   It inhibits glutamate release, but it also blocks postsynaptic NMDA- and kainate-type glutamate receptors and inhibits voltage-dependent Na+ channels,
Ref :-   Book : Basic & Clinical pharmacology    Page : 625   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Evening primrose oil with Another pathway,

  ►  Pathway with its reference as follows :-
  • Nerve stimulanet --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Faecal, Renal, Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 2613   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   9 hours,    Max value :-   15 hours,
    Ref :-   Book : Martindale    Page : 2613   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   0.5 hours,
    Ref :-   Book : Martindale    Page : 2613   Edition : 37,