Risperidone/Respidon is a Medicine belongs to Antipsychotic group whose information about Brand can be referenced from   Book : Martindale    Page : 1133   Edition : 37,

  ►   Brandname : Risperdal,Respidon,Rispa, Risocon, Risperdoc, Risnia

  ►  Strength : Tablet with 0.25  mg, Tablet with 0.5  Mg, Tablet with 1  mg, Tablet with 2  mg, Tablet with 3  Mg, Tablet with 4  mg, Disintegrating tablets with 0.5  mg, Disintegrating tablets with 1  mg, Disintegrating tablets with 2  mg, Disintegrating tablets with 3  mg, Disintegrating tablets with 4  mg, Oral solution with 1  mg/ml, Injection with 12.5  mg, Injection with 25  mg, Injection with 37.5  mg, Injection with 50  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 519   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM,
Reference :-   Book : Martindale    Page : 1132   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Schizophrenia Oral 2 mg Tablet This may be increased to 4 mg daily on the second day, and subsequently adjusted as required in steps of 1 or 2 mg according to tolerance, at intervals of not less than 24 hours.
2 Mania in bipolar disorder Oral 2 3 mg Tablet o.d. Dosage adjustments of 1 mg daily may be made at intervals of not less than 24 hours up to a total of 6 mg daily
3 Mania in bipolar disorder IM 25 mg Injection For maintenance therapy given every 2 weeks; some patients may benifit from a higher dose of 37.5 mg or 50 mg.
4 Persistent aggression in Alzheimer's disease Oral 250 micrograms Tablet b.d.

Ref :-  Book : Martindale    Page : 1132   Edition : 37,

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Schizophrenia or mania Oral 500 micrograms Tablet o.d.
2 Irritability associated with autistic disorder under 20 kg Oral 250 micrograms Tablet o.d.
3 Irritability associated with autistic disorder 20 kg and over Oral 500 micrograms Tablet o.d.
4 Persistent aggression in conduct disorder under 50 kg Oral 250 micrograms Tablet o.d.

Ref :- Book : Martindale    Page : 1132   Edition : 37,
►  Side Effect : insomnia, anxiety, headache, dyspepsia, nausea, vomiting, abdominal pain, constipation, Blurred Vision, sexual dysfunction, priapism, urinary incontinence, rash, allergic reaction, drowsiness, Dizziness, fatigue, rhinitis, Orthostatic hypotension, Cerebrovascular accident, tachycardia, weight gain, Concentration difficulties, oedema, Increase in liver enzyme values, ,
Ref :-   Book : Martindale    Page : 1130,1131   Edition : 37,

►  Drug Interaction : Drug interaction of Risperidone/Respidon is with Alcohol, Antihypertensive Agents , , ,  Levodopa , Carbamazapine , Fluoxetine ,
Ref :-   Book : Martindale    Page : 1131   Edition : 37,

  ►    Mechanism of Drug Drug Interaction :  The central effects of other CNS depressants, including alcohol, may be enhanced by risperidone. Risperidone may also enhance the effects of antihypertensives. There may be an increased risk of QT prolongation when risperidone is given with other drugs that are known to cause this effect. Risperidone may antagonise the actions of levodopa and other dopaminergics. Carbamazepine has been shown to decrease the antipsychotic fraction (risperidone plus 9-hydroxyrisperidone) of risperidone and a similar effect may be seen with other enzyme inducers. Fluoxetine may increase the plasma concentrations of the antipsychotic fraction by raising the concentration of risperidone. Dose adjustment of risperidone may be necessary in such situations. Increased mortality has been reported in elderly patients with dementia who are given risperidone and furosemide. Caution is advised when using risperidone with furosemide or other potent diuretics.,
Ref :-   Book : Martindale    Page : 1131   Edition : 37,

►  Contraindication : Risperidone should be used with caution in patients with cardiovascular disease, including conditions associated with QT prolongation, or conditions predisposing to hypotension., Caution is also recommended in patients with a history of or at risk of developing cerebrovascular disease, in patients with Parkinson’s disease or epilepsy, and in patients with hepatic or renal impairment.,
Ref :-   Book : Martindale    Page : 1131   Edition : 37,
  ►  Mechanism of Action :   Risperidone is a benzisoxazole atypical antipsychotic, reported to be an antagonist at dopamine D2, serotonin (5-HT2), adrenergic (α1 and α2), and histamine (H1) receptors.,
Ref :-   Book : Martindale    Page : 1132   Edition : 37,

Pathway of Dietry Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- with Another pathway, Poppy seed with Another pathway,

  ►  Pathway with its reference as follows :-
  • antipsychotic --- (Kokate, C. & Purohit, A. (2013). Pharmacognosy. Nirali prakashan: Chennai. )
  • Morphine have antipsychotic activity. --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html, https://www.sapnaonline.com/books/pharmacognosy-ck-kokate-8196396155-9788196396152,

    Dietry Substance Interactions

    ​   ► This Medicine interact with :- NA

    ContraIndication Dietry Substance

    ​   ► This Medicine contraindicate with :- 5 HTP(5-HYDROXYTRYPTOPHAN) with Cause anxiety,confusion & other side effect ., IODINE with Increase side effect, VITAMIN E with It reduce the sideffect of drug such as neuroleptic malignant syndrome .,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20, http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Faecal, Renal, Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 1132   Edition : 37,

    ►    Plasma Half-life :   Min value :-   19.5 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1132   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 1132   Edition : 37,