Rivaroxaban is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1524   Edition : 37,

  ►   Brandname : Xarelto

  ►  Strength : Tablet with 10  mg, Tablet with   , Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 617   Edition : 12, Martindale    Page : 1524   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 1524   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Prophylaxis of venous thromboembolism Oral 10 mg Tablet o.d. Prophylaxis of venous thromboembolism in patients under going hip or knee replacement surgery. The initial dose should be given 6 to 10 hours after surgery, providing haemostasis has been established, and treatment should be continued for 5 weeks after hip surgery and for 2 weeks after knee surgery.

Ref :-  Book : Martindale    Page : 1524   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : nausea, Increase in liver enzyme values, gastrointestinal effects, pruritus, Skin rashes,
Ref :-   Book : Martindale    Page : 1524   Edition : 37,

►  Drug Interaction : Drug interaction of Rivaroxaban is with HIV- protease inhibitors, ,  Ketoconazole , Itraconazole , Posaconazole , Voriconazole , Fluconazole , Clarithromycin , Erythromycin , Rifampicin ,
Ref :-   Book : Martindale    Page : 1524   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  , Rivaroxaban is metabolised by the cytochrome P450 isoenzyme CYP3A4 and is also a substrate P-glycoprotein. It should be given with potent inhibitors of both CYP3A4 and P-glycoprotein, such as ketoconazole, itraconazole, posaconazole, voriconazole, or HIV-protease inhibitors, although it may be used cautiously with fluconazole. Drugs that inhibit only one of these pathways or are less potent inhibitors, such as clarithromycin and erythromycin, do not appear to have clinically relevant effects. Potent inducers of CYP3A4, such as rifampicine, may reduce the effect of rivaroxaban. Caution is needed if rivaroxaban is given with other anticoagulants or with drugs that effect bleeding, incluing NSAIDS and antiplatelet drugs.,
Ref :-   Book :    Page :    Edition : , Martindale    Page : 1524   Edition : 37,


►  Contraindication : Patients with clinically significant bleeding or with hepatic disease associated with coagulopathy and clinically relevant bleeding risk, It should used with caution in other patients at increased risk of bleeding, Plasma concentrations are increased in hepatic or renal impairment and the risk of bleeding may be increased; rivaroxaban is not recommended in patients with creatinine clearance below 15mL/minute,
Ref :-   Book : Martindale    Page : 1524   Edition : 37,
  ►  Mechanism of Action :   Rivaroxaban is an oral direct inhibitor of factor Xa (activated factor X) with a dose-dependent effect on prothrombin time., ,
Ref :-   Book : Martindale    Page : 1524   Edition : 37,    Page :    Edition : ,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Amla with same pathway,

  ►  Pathway with its reference as follows :-
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )

  •   ►  URL -- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744903/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Faecal, Renal,
    Ref :-   Book : Martindale    Page : 1524   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 1524   Edition : 37,