Rivastigmine is a Medicine belongs to CHOLINESTERASE INHIBITORS group whose information about Brand can be referenced from   Book : Martindale    Page : 400   Edition : 37,

  ►   Brandname : Exelon

  ►  Strength : Tablet with 1.5  mg, Tablet with 3  mg, Tablet with 4.5  mg, Tablet with 6  Mg, Solution with 2  mg/ml, Transdermal Patch with 4.6 or 9.5  mg/24 h,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 112   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Transdermal,
Reference :-   Book : Martindale    Page : 400   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Symptomatic treatment of mild to moderately severe dementia in Alzheimer’s disease and idiopathic Parkinson’s disease Oral 1.5 mg Tablet Dose: Given daily with food. Thereafter, the dose may be increased according to response and tolerance by increments of 1.5 mg twice daily at intervals of at least 2 weeks to a maximum dose of 6 mg twice daily.
2 Symptomatic treatment of mild to moderately severe dementia in Alzheimer’s disease and idiopathic Parkinson’s disease Transdermal 4.6 or 9.5 mg Transdermal Patch o.d. • those taking 6 mg daily or less of oral rivastigmine may be switched to patches delivering 4.6 mg over 24 hours • those taking more than 6 mg daily orally may be switched to patches delivering 9.5 mg over 24 hours

Ref :-  Book : Martindale    Page : 400   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Application site reactions such as erythema, pruritus, rash, and vesicles have been seen with transdermal use of rivastigmine, nausea, vomiting, anorexia, diarrhoea, fatigue, Dizziness, abdominal pain, dyspepsia, Rashes, pruritus, headache, Somnolence, muscle cramp, insomnia, sweating, tremor, syncope, urinary-tract infections, Psychiatric disturbances, Depression, hallucinations, agitation, aggressive behaviour, Confusion, ,
Ref :-   Book : Martindale    Page : 394,399   Edition : 37,

►  Drug Interaction : Drug interaction of Rivastigmine is with AMINOGLYCOSIDES , , , ,  Colistin, Quinine , Chloroquine , Hydroxychloroquine , Quinidine , Procainamide , Propafenone, Suxamethonium/Succinylcholinechloride (Suxamethonium chloride) ,
Ref :-   Book : Martindale    Page : 394,399,687   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Drugs with neuromuscular blocking activity, such as the aminoglycosides, clindamycin, colistin, cyclopropane, and the halogenated inhalational anaesthetics, may antagonise the effects of rivastigmine. Those such as quinine, chloroquine, hydroxychloroquine, quinidine, procainamide, propafenone, lithium, and the beta blockers, that have the potential to aggravate myasthenia gravis, can reduce the effectiveness of treatment with parasympathomimetics. Prolonged bradycardia has also occurred in patients receiving beta blockers when given rivastigmine. Anticholinesterases, such as rivastigmine, can inhibit the metabolism of suxamethonium and enhance and prolong its action; combined use is not recommended. Although antimuscarinics are expected to antagonise the effects of anticholinesterases, such combinations are sometimes used in patients with dementia who are distressed by symptoms of urge incontinence. There have been, however, a few cases of agitation, anxiety, confusion, aggression, and delusion precipitated by tolterodine in patients who had been stable on donepezil or rivastigmine.,
Ref :-   Book : Martindale    Page : 394,399,687   Edition : 37,


►  Contraindication : , Gastrointestinal obstruction, Urinary-Tract Obstruction, Care is also required in patients with a history of asthma, obstructive pulmonary disease, Parkinson’s disease, or seizures, and in those, with, or at risk of developing, peptic ulcer disease, Patients with cardiovascular conduction disorders such as sick-sinus syndrome may be susceptible to the vagotonic effects of acetylcholinesterase inhibitors,
Ref :-   Book :    Page :    Edition : , Martindale    Page : 394,399   Edition : 37,
  ►  Mechanism of Action :   Rivastigmine is a carbamate type reversible acetylcholinesterase inhibitor; it also inhibits butyrylcholinesterase.,
Ref :-   Book : Martindale    Page : 400   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Valerian with Another pathway, Ficus Religiosa i.e. figs with same pathway, Beilschmieda i.e.dalzells walnut with same pathway, Skimmia laureola with same pathway, Esenbeckia leicarpa with same pathway, Corydalis cava with same pathway, Catharanthus roseus i.e. sadabahar with same pathway, Ervatamia hainanesis with same pathway, Tabernaemontana i. e. Chandni. with same pathway, Uncaria rhynchophylla with same pathway, Himatanthus lancifolius e.i.agoniada. with same pathway, Hippeastrum papilio with same pathway, Huperzia serrata with same pathway, Andrographis paniculata with same pathway, Salsola oppositifolia with same pathway, Salsola tragus with same pathway, Crinum moorei e.i. lily with same pathway, Crinum moorei e.i. lily with same pathway, Nerine undulata with same pathway, Scadoxus multiflorus i.e. lily with same pathway, Sprekelia formosissima with same pathway, Zephyranthes grandiflora with same pathway, Kaempfera parviflora with same pathway, Harpephyllum caffrum with same pathway, Ashwagandha with same pathway, Pistachios with same pathway, Sclerocarya birrea with same pathway, Spondias mombin with same pathway, Gotu Kola with same pathway, Black pepper with same pathway,

  ►  Pathway with its reference as follows :-
  • Anti-anxiety activity --- (Kokate, C.K. and A.p. Purohit. Pharmacognosy. Nirali prakashan: Chennai, 2013. Print. )
  • Acetyl cholinesatrase inhibitor --- (Chandrashekher, S .B. "Phytopharmacology Of Ficus Religiosa". Pharmacogn 4.8 (2010): 195–199. Web. 9 Nov. 2016. )
  • acetyl cholinestrase inhibitor --- (Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor m --- (Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- (Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- (Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- (Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- (Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- (Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- (Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- (Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- (Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- (Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • Acetylcholistrase inhibitor --- (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744903/ )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- (Murray A. Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr nuropharmacol. 2013;11(4):388–413. )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- (Murray A. Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr nuropharmacol. 2013;11(4):388–413. )
  • Acetylcholistrase inhibitor --- (Murray A. Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr nuropharmacol. 2013;11(4):388–413. )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249921/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744903/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 399   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   1 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 399   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 399   Edition : 37,