Rizatriptan is a Medicine belongs to antimigraine drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 679   Edition : 37,

  ►   Brandname : Rizact,Maxalt

  ►  Strength : Tablet with 5  mg, Tablet with 10  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 292   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 679   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Acute treatment of headache phase of migraine attacks Oral 10 mg Tablet If this is ineffective, a second dose should not be taken for the same attack. If symptoms recur after an initial response, a further dose of 10 mg may be taken after an interval of at least 2 hours.

Ref :-  Book : Martindale    Page : 679   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 MIGRAINE HEADACHES Oral 5 10 mg Tablet

Ref :- Book : Nelson's textbook of Pediatrics    Page : 2044   Edition : 19,
►  Side Effect : paraesthesia, asthenia, fatigue, flushing, feelings of pressure, tightness, Pain in the chest, Pain in the neck, Pain in the jaw, drowsiness, Dizziness, nausea, sweating, ,
Ref :-   Book : Goodman    Page : 346   Edition : 12,

►  Drug Interaction : Drug interaction of Rizatriptan is with Propranolol , Ergotamine, Methysergide,
Ref :-   Book : Martindale    Page : 679,681   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Propranolol increases plasma-rizatriptan concentrations and it is recommended that lower doses of rizatriptan should be used in patients receiving both drugs. It should not be given with ergotamine or related compounds (including methysergide) since there is an increased risk of vasospastic reactions.,
Ref :-   Book : Martindale    Page : 679,681   Edition : 37,


►  Contraindication : Severe hepatic impairment, severe renal impairment, History of ischemic disease, History of vasospastic coronary artery disease (including history of stroke or transient ischemic attacks), Cerebrovascular disease, Peripheral vascular disease, Hemiplegic migraines, Basilar migraines, cardiovascular disease, Ischemic bowel diseases, Uncontrolled hypertension, It is contraindicated in patients who have taken a monoamine oxidase inhibitor within the preceding 2 weeks, and all triptans are contraindicated in patients with near-term prior exposure to ergot alkaloids or other 5-HT agonists.,
Ref :-   Book : Goodman    Page : 346   Edition : 37, Goodman    Page : 346   Edition : 12,
  ►  Mechanism of Action :   It is a selective serotonin agonist that acts at 5-HT1 receptors and produces vasoconstriction of cranial arteries. ,
Ref :-   Book : Martindale    Page : 679,681   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 679   Edition : 37,


►    Plasma Half-life :
  Min value :-   2 hours,    Max value :-   3 hours,
Ref :-   Book : Martindale    Page : 679   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2.5 hours,
Ref :-   Book : Martindale    Page : 679   Edition : 37,