Rocuronium is a Medicine belongs to Neuromuscular blocking drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 2073   Edition : 37  

  ►   Brandname : Esmeron, Zemuron
  ►  Strength : Injection with 10 mg/ml. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 481   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV
Reference :-   Book : Basic & Clinical pharmacology    Page : 481   Edition : 12  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Endotracheal intubation and to provide muscle relaxation in general anaesthesia for surgical procedures and to aid controlled ventilation IV 600 microgram/kg Injection Higher doses of 1 mg/kg are recommended for intubation during rapid sequence induction of anaesthesia. Usual maintenance doses are 150 micrograms/kg by injection, although these should be reduced to 75 to 100 micrograms/kg if prolonged inhalational anaesthesia is planned
2 Conditions for intubation IV 600 900 mcg/kg Injection

Ref :-  Book : Martindale    Page : 2073   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Conditions for intubation IV 600 900 micrograms/kg Injection

Ref :- Book : Martindale    Page : 2073   Edition : 37  
►  Side Effect : Rocuronium is reported to have minimal cardiovascular and histamine-releasing effects. High doses (greater than 900 micrograms/kg of rocuronium bromide) have mild vagolytic activity, Competitive neuromuscular blockers with vagolytic activity may produce tachycardia and a rise in blood pressure., The use of blockers that lack an effect on the vagus will not counteract the bradycardia produced during anaesthesia by the other drugs employed or by vagal stimulation., Reduction in blood pressure with compensatory tachycardia may occur with some competitive neuromuscular blockers, in part because of sympathetic ganglion blockade or the release of histamine., Reduction in gastrointestinal motility and tone may occur as a result of ganglionic blockade., Histamine release may also lead to wheal-and-flare effects at the site of injection, flushing, occasionally bronchospasm
Ref :-   Book : Martindale    Page : 2066,2072   Edition : 37.  

►  Drug Interaction : Drug interaction of Rocuronium is with AMINOGLYCOSIDES , , , TETRACYCLINES ,  Lidocaine , Procainamide , Quinidine , Verapamil , Clindamycin , Lincomycin
Ref :-   Book : Martindale    Page : 2066,2072   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  Some drugs may influence neuromuscular transmission and thus interfere with the action of both competitive and depolarising neuromuscular blockers, resulting in potentiation or antagonism of neuromuscular block. Some interactions may be advantageous, such as the reversal of competitive neuromuscular block by anticholinesterases. In general, adverse interactions are potentially more serious in patients with impaired neuromuscular function. Lidocaine, procainamide, quinidine, and verapamil all have some neuromuscular blocking activity and may enhance the block produced by neuromuscular blockers. Some antibacterials in very high concentration can produce a muscle paralysis that may be additive to or synergistic with that produced by neuromuscular blockers. The neuromuscular block produced by antibacterials may be enhanced in patients with intracellular potassium deficiency, low plasma-calcium concentration, neuromuscular disease, or a tendency to a high plasma-antibacterial concentration, for example after large doses or in renal impairment. The antibacterials most commonly implicated are aminoglycosides, lincosamides, polymyxins, and, more rarely, tetracyclines. The lincosamides (clindamycin and lincomycin) can prolong the action of muscle relaxants producing a neuromuscular block that may be difficult to reverse with calcium or anticholinesterases.
Ref :-   Book : Martindale    Page : 2067,2072   Edition : 37.  

►  Contraindication : It should be used with caution in patients with biliary disease or hepatic or renal impairment., The response to neuromuscular blockers is often unpredictable in patients with neuromuscular disorders and they should be used with great care in these patients, Caution is also needed in patients with a history of conditions such as asthma where release of histamine would be a hazard., Care is also required in patients with a history of hypersensitivity to any neuromuscular blocker because high rates of cross-sensitivity have been reported.
Ref :-   Book : Martindale    Page : 2066,2072   Edition : 37.  
  ►  Mechanism of Action :   Rocuronium bromide is an aminosteroidal competitive neuromuscular blocker. It act by competing with acetylcholine for receptors on the motor end-plate of the neuromuscular junction to produce blockade.
Ref :-   Book : Martindale    Page : 2069,2073   Edition : 37.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Biliary, Renal
Ref :-   Book : Martindale    Page : 2072   Edition : 37.  

►    Plasma Half-life :   Min value :-   1.2 hours,    Max value :-   1.4 hours.  
Ref :-   Book : Martindale    Page : 2072   Edition : 37.  

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA