Rocuronium is a Medicine belongs to Neuromuscular blocking drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 2073   Edition : 37,

  ►   Brandname : Esmeron,Zemuron

  ►  Strength : Injection with 10  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 481   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Basic & Clinical pharmacology    Page : 481   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Endotracheal intubation and to provide muscle relaxation in general anaesthesia for surgical procedures and to aid controlled ventilation IV 600 microgram/kg Injection Higher doses of 1 mg/kg are recommended for intubation during rapid sequence induction of anaesthesia. Usual maintenance doses are 150 micrograms/kg by injection, although these should be reduced to 75 to 100 micrograms/kg if prolonged inhalational anaesthesia is planned
2 Conditions for intubation IV 600 900 mcg/kg Injection

Ref :-  Book : Martindale    Page : 2073   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Conditions for intubation IV 600 900 micrograms/kg Injection

Ref :- Book : Martindale    Page : 2073   Edition : 37,
►  Side Effect : NA

►  Drug Interaction : Drug interaction of Rocuronium is with botulinumtoxins,  Lidocaine , Procainamide , Quinidine , Verapamil , Isradipine , aminoglycoside, Lincosamides , Polymyxin B, Polymyxin B, Tetracycline , Neostigmine , Pyridostigmine , Rivastigmine , Donepezil , Ethanol , Aprotinin, Fospropofol , Mivacurium Chloride , Verapamil , Nicardipine , Repaglinide , Testosterone , Ketamine , Felbamate, Zonisamide , Acarbose , Lacosamide , Potassium Permanganate ,
Ref :-   Book : Martindale    Page : 2067,2068,2069   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  A number of drugs may influence neuromuscular transmission and thus interfere with the action of both competitive and depolarising neuromuscular blockers, resulting in potentiation or antagonism of neuromuscular block. Lidocaine, procainamide, quinidine, and verapamil all have some neuromuscular blocking activity and may enhance the block produced by neuromuscular blockers. Some antibacterials in very high concentration can produce a muscle paralysis that may be additive to or synergistic with that produced by neuromuscular blockers. There are reports of potentiation of neuromuscular blockade occurring with many different aminoglycoside neuromuscular blocker combinations. The lincosamides (clindamycin and lincomycin) can prolong the action of muscle relaxants producing a neuromuscular block that may be difficult to reverse with calcium or anticholinesterases. There have been reports of prolonged apnoea after use of polymyxins (colistin, polymyxin B) with a neuromuscular blocker. Tetracyclines have weak neuromuscular blocking properties; potentiation of neuromuscular block has been reported in patients with myasthenia gravis. Anticholinesterases, including ecothiopate, edrophonium, galantamine, neostigmine, pyridostigmine, rivastigmine, and possibly donepezil, antagonise the effect of competitive neuromuscular blockers. The neuromuscular block induced by botulinum toxins is enhanced by competitive neuromuscular blockers. Verapamil may interfere with the release of acetylcholine and prolonged use may lead to a reduction in intracellular calcium concentration. Neuromuscular blockers are potentiated in a dose-dependent manner by inhalation anaesthetics. There have been isolated reports of prolonged neuromuscular blockade after the use of neuromuscular blockers in patients receiving lithium. Parenteral magnesium salts may potentiate the effects of competitive and depolarising neuromuscular blockers.,
Ref :-   Book : Martindale    Page : 2067,2068,2069   Edition : 37,


►  Contraindication : biliary disease, hepatic impairment, renal impairment,
Ref :-   Book : Martindale    Page : 2072   Edition : 37,
  ►  Mechanism of Action :   Rocuronium bromide is an aminosteroidal competitive neuromuscular blocker. It act by competing with acetylcholine for receptors on the motor end-plate of the neuromuscular junction to produce blockade.,
Ref :-   Book : Martindale    Page : 2069,2073   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Biliary, Renal,
Ref :-   Book : Martindale    Page : 2072   Edition : 37,


►    Plasma Half-life :
  Min value :-   1.2 hours,    Max value :-   1.4 hours,
Ref :-   Book : Martindale    Page : 2072   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA