Ropinirole is a Medicine belongs to Antiparkinsonian Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 901   Edition : 37  

  ►   Brandname : Requip, Adartrel
  ►  Strength : Tablet with 0.25 mg.  Tablet with 0.5 mg.  Tablet with 1 mg.  Tablet with 2 Mg.  Tablet with 3 mg.  Tablet with 4 mg.  Tablet with 5 mg.  Tablet (Extended Release Tablets) with 2 mg.  Tablet (Extended Release Tablets) with 4 mg.  Tablet (Extended Release Tablets) with 6 mg.  Tablet (Extended Release Tablets) with 8 mg.  Tablet (Extended Release Tablets) with 12 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 498   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Basic & Clinical pharmacology    Page : 498   Edition : 12  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Parkinson’s disease Oral 750 micrograms Tablet Dose: increased at weekly intervals in steps of 750 micrograms for the first 4 weeks. After week 4, the weekly increments may be made in steps of 1.5 mg up to a dose of 9 mg daily according to response; subsequent weekly increments may be made in steps of up to 3 mg. The daily dosage should not exceed 24 mg.
2 Restless leg syndrome Oral 250 micrograms Tablet Ropinirole is given as a single daily dose, 1 to 3 hours before bedtime. Dose given daily for 2 days; if tolerated, the dose is then increased to 500 micrograms daily for the rest of the first week. Dosage is then increased as necessary up to a maximum of 4 mg daily. Increases are made weekly in steps of 500 micrograms up to a dose 3 mg daily; a final increase after one further week of 1 mg to a dose of 4 mg daily can then be made.

Ref :-  Book : Martindale    Page : 901   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :    Page :    Edition :   
►  Side Effect : Hypersensitivity reactions, Angioedema, pruritus, Rashes, Urticaria, In the treatment of restless legs syndrome, earlier onset of symptoms in the afternoon or evening (augmentation) and recurrence of symptoms in the early morning hours (rebound) have been reported with ropinirole., Nausea, Vomiting, Dizziness, Orthostatic hypotension, Syncope, Raynaud’s syndrome or digital vasospasm, induced by cold, and leg cramps, Erythromelalgia, Prolonged severe hypotension, Arrhythmias, Exacerbation of angina, Retroperitoneal fibrosis, Pleural thickening and effusions, Pericarditis, Pericardial effusion, Headache, Nasal congestion, Drowsiness, Dry mouth, Constipation, Diarrhoea, Altered liver function tests, Dyskinesias, psychomotor excitation, Gastrointestinal bleeding, Psychosis, with hallucinations, Delusion, Confusion
Ref :-   Book : Martindale    Page : 882,900   Edition : 37.  

►  Drug Interaction : Drug interaction of Ropinirole is with Phenothiazines, Butyrophenones, Thioxanthenes, Macrolide antibacterials,  Oestrogen, Metoclopramide , Memantine hydrochloride , Octreotide
Ref :-   Book : Martindale    Page : 884, 900   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  It is a dopamine agonist, ropinirole may share some of the pharmacological interactions of bromocriptine, Dopamine antagonists such as the phenothiazines, butyrophenones, thioxanthenes, and metoclopramide might be expected to reduce the prolactin- lowering and the antiparkinsonian effects of bromocriptine and domperidone might reduce its prolactin- lowering effect. Memantine may enhance the effects of bromocriptine. Stimulants of gastrointestinal motility such as macrolide antibacterials or octreotide can increase the bioavailability of bromocriptine. In addition, high doses of oestrogens can increase plasma oncentrations of ropinirole and dosage adjustments may be necessary if oestrogen therapy is started or withdrawn during treatment with ropinirole. Ropinirole is metabolised by the cytochrome P450 isoenzyme CYP1A2 and there is therefore the potential for interactions between ropinirole and other drugs that are metabolised similarly or more particularly with inducers or inhibitors of this enzyme. Dosage adjustments may be necessary if therapy with such drugs is started or withdrawn during treatment with ropinirole
Ref :-   Book : Martindale    Page : 884, 900   Edition : 37.  

►  Contraindication : Patients with hyperprolactinaemia should be investigated for the possibility of a pituitary tumour before treatment, Malignancy must be excluded in patients with cyclical benign breast disorders such as mastalgia, Annual gynaecological examinations (or every 6 months for postmenopausal women) are recommended., Treatment of women with hyperprolactinaemic amenorrhoea results in ovulation; patients not wishing to conceive should be advised to use contraceptive measures., Acromegalic patients should be checked for symptoms of peptic ulceration before therapy and should immediately report symptoms of gastrointestinal discomfort during therapy., It should be given with caution to patients with cardiovascular disease, Raynaud’s syndrome, or a history of psychosis., It is contra-indicated in patients with hypersensitivity to bromocriptine or other ergot alkaloids, and in those with uncontrolled hypertension., It is contra-indicated in the toxaemia of pregnancy., It should also not be used postpartum or in the puerperium in women with hypertension, coronary artery disease, or symptoms or a history of serious psychiatric disorders., When used, blood pressure should be monitored carefully., Treatment in postpartum women should be stopped immediately if hypertension, unremitting headache, or signs of CNS toxicity develop., Excessive daytime sleepiness and sudden onset of sleep may also occur, Caution is advised when driving or operating machinery; patients who suffer such effects should not drive or operate machinery until the effects have stopped recurring, High-dose therapy should be monitored for signs of progressive fibrotic disorders, Periodic monitoring of cardiovascular, haematopoietic, hepatic, and renal function is also recommended.
Ref :-   Book : Martindale    Page : 883,900   Edition : 37.  
  ►  Mechanism of Action :   Ropinirole is a non-ergot dopamine D2-agonist. It inhibits the secretion of prolactin from the anterior pituitary and is used in the treatment of prolactinoma and endocrinological disorders associated with hyperprolactinaemia, including amenorrhoea, galactorrhoea, hypogonadism, and infertility in both men and women.
Ref :-   Book : Martindale    Page : 884, 900   Edition : 37.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- Fava beans i.e. bakla with same compound.  

  ►  Pathway with its reference as follows :-
  • Fava beans rich in levo-dihydroxyphenylalanine(L-Dopa) the precursor of dopamine. --- (Mehran S.M., Mohseni. "Simultaneous Determination Of Levodopa And Carbidopa From Fava Bean, Green Peas And Green Beans By High Performance Liquid Gas Chromatography". JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH (2013): n. pag. Web. 10 Nov. 2016. )

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  • DIETARY Substance Interactions

    ​   ► This Medicine interact with :- NA

    ContraIndication DIETARY Substance

    ​   ► This Medicine contraindicate with :- AGNUS CASTUS I.E. NIRGANDHI with Nirgandhi interact with dopamine agonist drug.  

      ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

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    ►   Route of Elimination :   Hepatic (Metabolism), Renal
    Ref :-   Book : Martindale    Page : 900   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   6 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 900   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   1.5 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 900   Edition : 37.