Ropinirole is a Medicine belongs to Antiparkinsonian Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 901   Edition : 37,

  ►   Brandname : Requip,Adartrel

  ►  Strength : Tablet with 0.25  mg, Tablet with 0.5  mg, Tablet with 1  mg, Tablet with 2  Mg, Tablet with 3  mg, Tablet with 4  mg, Tablet with 5  mg, Tablet (Extended Release Tablets) with 2  mg, Tablet (Extended Release Tablets) with 4  mg, Tablet (Extended Release Tablets) with 6  mg, Tablet (Extended Release Tablets) with 8  mg, Tablet (Extended Release Tablets) with 12  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 498   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 498   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Parkinsonism Oral 750 micrograms Tablet Dose: increased at weekly intervals in steps of 750 micrograms for the first 4 weeks. After week 4, the weekly increments may be made in steps of 1.5 mg up to a dose of 9 mg daily according to response; subsequent weekly increments may be made in steps of up to 3 mg. The daily dosage should not exceed 24 mg.
2 Restless leg syndrome Oral 250 micrograms Tablet Dose: Given daily.

Ref :-  Book : Martindale    Page : 901   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : diarrhea, Dizziness, drowsiness, dry mouth, headache, nasal congestion, Somnolence, acromegaly, altered liver function tests, Arrhythmias, Blurred Vision, cardiac valve fibrosis, delusion, erythromelalgia, exacerbation of angina, Orthostatic hypotension, psychoses, Raynaud’s syndrome, syncope,
Ref :-   Book : Martindale    Page : 882   Edition : 37,

►  Drug Interaction : Drug interaction of Ropinirole is with oestrogen,
Ref :-   Book : Martindale    Page : 900   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  it is a dopamine agonist, ropinirole may share some of the pharmacological interactions of bromocriptine, Dopamine antagonists such as the phenothiazines, butyrophenones, thioxanthenes, and metoclopramide might be expected to reduce the prolactin- lowering and the antiparkinsonian effects of bromocriptine and domperidone might reduce its prolactin- lowering effect. Memantine may enhance the effects of bromocriptine. Stimulants of gastrointestinal motility such as macrolide antibacterials or octreotide can increase the bioavailability of bromocriptine. In addition, high doses of oestrogens can increase plasma oncentrations of ropinirole and dosage adjustments may be necessary if oestrogen therapy is started or withdrawn during treatment with ropinirole. Ropinirole is metabolised by the cytochrome P450 isoenzyme CYP1A2 and there is therefore the potential for interactions between ropinirole and other drugs that are metabolised similarly or more particularly with inducers or inhibitors of this enzyme. Dosage adjustments may be necessary if therapy with such drugs is started or withdrawn during treatment with ropinirole,
Ref :-   Book : Martindale    Page : 884, 900   Edition : 37,


►  Contraindication : hepatic impairment, renal impairment,
Ref :-   Book : Martindale    Page : 900   Edition : 37,
  ►  Mechanism of Action :   Ropinirole is a non-ergot dopamine agonist(D3) It inhibits the secretion of prolactin from the anterior pituitary,
Ref :-   Book : Martindale    Page : 884, 900   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Fava beans i.e. bakla with same compound,

  ►  Pathway with its reference as follows :-
  • Fava beans rich in levo-dihydroxyphenylalanine(L-Dopa) the precursor of dopamine. --- (Mehran S.M., Mohseni. "Simultaneous Determination Of Levodopa And Carbidopa From Fava Bean, Green Peas And Green Beans By High Performance Liquid Gas Chromatography". JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH (2013): n. pag. Web. 10 Nov. 2016. )

  •   ►  URL -- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708185/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- AGNUS CASTUS I.E. NIRGANDHI with Nirgandhi interact with dopamine agonist drug,

      ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 900   Edition : 37,


    ►    Plasma Half-life :   Min value :-   6 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 937   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   1.5 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 937   Edition : 37,