Ropivacaine is a Medicine belongs to Local anaesthetics group whose information about Brand can be referenced from   Book : Martindale    Page : 2033   Edition : 37,

  ►   Brandname : Naropin

  ►  Strength : Injection with 0.2  %, Injection with 0.5  %, Injection with 0.75  %, Injection with 1.0  %,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 463   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : parentral,
Reference :-   Book : Martindale    Page : 2032   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Surgical anaesthesia- lumbar epidural block Injection Dose: 75 to 150 mg (15 to 30 mL) as a 0.5% solution, or 112.5 to 187.5 mg (15 to 25 mL) as a 0.75% solution, or 150 to 200 mg (15 to 20 mL) as a 1% solution; for caesarean section, doses are 100 to 150 mg (20 to 30 mL) as a 0.5% solution or 112.5 to 150 mg (15 to 20 mL) as a 0.75% solution.
2 Surgical anaesthesia- Thoracic epidural block to establish a block for postoperative pain relief Injection Dose: 25 to 75 mg (5 to 15 mL) as a 0.5% solution or 37.5 to 112.5 mg (5 to 15 mL) as a 0.75% solution; the actual dose used depends on the level of the injection.
3 Peripheral nerve block of major nerves such as the brachial plexus Injection Dose: 175 to 250 mg (35 to 50 mL) as a 0.5% solution; 225 to 300 mg (30 to 40 mL) as a 0.75% solution has also been recommended for brachial plexus block.
4 Infiltration anaesthesia and field block Injection Dose: up to 200 mg (40 mL) as a 0.5% solution or up to 225 mg (30 mL) as a 0.75% solution may be used.
5 Acute pain Injection Dose: 0.2% solution for epidural block (0.5% solutions may be used for infiltration). Doses for lumbar epidural block are 20 to 40 mg (10 to 20 mL) as an initial bolus followed by 20 to 30 mg (10 to 15 mL) at intervals of not less than 30 minutes.

Ref :-  Book : Martindale    Page : 2032   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Management of peri- and postoperative pain Injection

Ref :- Book : Martindale    Page : 2032   Edition : 37,
►  Side Effect : Restlessness, excitement, Nervousness, paraesthesia, Dizziness, tinnitus, Blurred Vision, nausea, vomiting, muscle twitching, tremor, convulsion, Numbness of the tongue and perioral region, lightheadedness, Depression, drowsiness, respiratory failure, coma, hypotension, bradycardia, Arrhythmias, cardiac arrest, ,
Ref :-   Book : Martindale    Page : 2011,2032   Edition : 37,

►  Drug Interaction : Drug interaction of Ropivacaine is with Fluvoxamine, Rifampicin ,
Ref :-   Book : Martindale    Page : 2032   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Giving ropivacaine with general anaesthetics, opioid analgesics, or drugs structurally related to amide-type local anaesthetics (e.g. certain antiarrhythmics) may result in potentiation of adverse effects. The metabolism of ropivacaine is mediated by the cytochrome P450 isoenzyme CYP1A2 and the potential exists for interactions between ropivacaine and other drugs that inhibit or act as a substrate for this isoenzyme. Prolonged use of ropivacaine should be avoided in patients treated with potent CYP1A2 inhibitors, such as fluvoxamine. Plasma concentrations of ropivacaine may be reduced by enzyme-inducing drugs such as rifampicin. ,
Ref :-   Book : Martindale    Page : 2032   Edition : 37,


►  Contraindication : Ropivacaine is contra-indicated for use in intravenous regional anaesthesia (Bier’s block) and for paracervical block in obstetrics., Hypersensitivity, Local anaesthetics should not be used in patients with complete heart block, Because of the risk of systemic adverse effects when local anaesthetics are absorbed too rapidly, they should not be injected into or applied to inflamed or infected tissues or to damaged skin or mucosa.,
Ref :-   Book : Martindale    Page : 2011,2032   Edition : 37,
  ►  Mechanism of Action :   Ropivacaine hydrochloride is a local anaesthetic of the amide type.It act by preventing the generation and transmission of impulses along nerve fibres and at nerve endings; depolarisation and ion-exchange are inhibited.,
Ref :-   Book : Martindale    Page : 2013-2032   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism), Renal,
Ref :-   Book : Martindale    Page : 2032   Edition : 37,


►    Plasma Half-life :
  Min value :-   1.8 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 2032   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
Ref :-   Book :    Page :    Edition : ,