Ropivacaine is a Medicine belongs to Local anaesthetics group whose information about Brand can be referenced from   Book : Martindale    Page : 2033   Edition : 37,

  ►   Brandname : Naropin

  ►  Strength : Injection with 0.2  %, Injection with 0.5  %, Injection with 0.75  %, Injection with 1.0  %,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 463   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : parentral,
Reference :-   Book : Martindale    Page : 2032   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Surgical anaesthesia- lumbar epidural block Injection Dose: 75 to 150 mg (15 to 30 mL) as a 0.5% solution, or 112.5 to 187.5 mg (15 to 25 mL) as a 0.75% solution, or 150 to 200 mg (15 to 20 mL) as a 1% solution for caesarean section, doses are 100 to 150 mg (20 to 30 mL) as a 0.5% solution or 112.5 to 150 mg (15 to 20 mL) as a 0.75% solution.
2 Surgical anaesthesia- thoracic epidural block Injection Dose: 25 to 75 mg (5 to 15 mL) as a 0.5% solution or 37.5 to 112.5 mg (5 to 15 mL) as a 0.75% solution; the actual dose used depends on the level of the injection.
3 Peripheral nerve block Injection Dose: 175 to 250 mg (35 to 50 mL) as a 0.5% solution; 225 to 300 mg (30 to 40 mL) as a 0.75% solution has also been recommended for brachial plexus block.
4 Infiltration anaesthesia and field block Injection Dose: up to 200 mg (40 mL) as a 0.5% solution or up to 225 mg (30 mL) as a 0.75% solution may be used.

Ref :-  Book : Martindale    Page : 2023   Edition : 37, Martindale    Page : 2032   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Caudal epidural block 0.2 % Injection

Ref :- Book : Martindale    Page : 2032   Edition : 37,
►  Side Effect : Restlessness, excitement, Nervousness, paraesthesia, Dizziness, tinnitus, Blurred Vision, nausea, vomiting, muscle twitching, tremor, convulsion, Fetal intoxication, corneal damage, hypotension, backache, Neurological complications, Cauda equina syndrome, vertigo, nystagmus, hypersenstivity, methaemoglobinaemia,
Ref :-   Book : Martindale    Page : 2011,2012   Edition : 37,

►  Drug Interaction : Drug interaction of Ropivacaine is with Abatacept , Fluvoxamine, Rifampicin ,
Ref :-   Book : Martindale    Page : 2013,2032   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  There is an increased risk of myocardial depression when amide-type local anaesthetics such as bupivacaine, levobupivacaine, lidocaine, or ropivacaine are given with antiarrhythmics. The metabolism of ropivacaine is mediated by the cytochrome P450 isoenzyme CYP1A2 and the potential exists for interactions between ropivacaine and other drugs that inhibit or act as a substrate for this isoenzyme. Prolonged use of ropivacaine should be avoided in patients treated with potent CYP1A2 inhibitors, such as fluvoxamine. Plasma concentrations of ropivacaine may be reduced by enzyme-inducing drugs such as rifampicin.,
Ref :-   Book : Martindale    Page : 2013-2032   Edition : 37,


►  Contraindication : Hypersensitivity, Epilepsy, Cardiac conduction system defects, shock, hepatic impairment, myasthenia gravis,
Ref :-   Book : Martindale    Page : 2011-2032   Edition : 37,
  ►  Mechanism of Action :   Ropivacaine hydrochloride is a local anaesthetic of the amide type.It act by preventing the generation and transmission of impulses along nerve fibres and at nerve endings; depolarisation and ion-exchange are inhibited.,
Ref :-   Book : Martindale    Page : 2013-2032   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism), Renal,
Ref :-   Book : Martindale    Page : 2032   Edition : 37,


►    Plasma Half-life :
  Min value :-   1.8 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 2032   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
Ref :-   Book :    Page :    Edition : ,