Rosiglitazone is a Medicine belongs to Thiazolidinedione derivatives/antidiabetic group whose information about Brand can be referenced from   Book : Martindale    Page : 500   Edition : 37, Basic & Clinical pharmacology    Page : 766   Edition : 12,

  ►   Brandname : Rezult,Roglin,Rosicon,Avandia,Avandamet, Avandaryl

  ►  Strength : Tablet with 2  mg, Tablet with 4  mg, Tablet with 8  mg, Tablet with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 766   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 766   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Type 2 diabetes mellitus Oral 4 mg Tablet Dose: given in a single dose or two divided doses. The dose may be increased to a maximum of 8 mg daily if necessary after 8 to 12 weeks in patients receiving monotherapy or combination oral therapy. Rosiglitazone may be taken with or without food.

Ref :-  Book : Martindale    Page : 500   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Type 2 diabetes mellitus Oral 4 8 mg Tablet

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1992   Edition : 19,
►  Side Effect : Hypoglycaemia, weight gain, Increased appetite, Gastrointestinal disturbances, headache, Reduction in haemoglobin and haematocrit, hypertriglyceridaemia, Mild to moderate hypercholesterolemia, Dizziness, palpitations, muscle cramp, back pain, arthralgia, paraesthesia, alopecia, ,
Ref :-   Book : Martindale    Page : 498   Edition : 37,

►  Drug Interaction : Drug interaction of Rosiglitazone is with Gemfibrozil , Ketoconazole , Trimethoprim , Rifampicin ,
Ref :-   Book : Martindale    Page : 499   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Gemfibrozil, ketoconazole, and trimethoprim, can increase plasma concentrations of rosiglitazone. Conversely, rifampicin can reduce rosiglitazone concentrations. These drugs should be given with caution to patients taking rosiglitazone, and glycaemic control should be monitored. Use of NSAIDs or insulin with rosiglitazone may increase the risk of oedema and heart failure.,
Ref :-   Book : Martindale    Page : 499   Edition : 37,


►  Contraindication : hepatic impairment, renal impairment, Rosiglitazone can cause fluid retention, which may worsen or precipitate heart failure; rapid weight gain and dyspnea may be indicative of fluid retention. It should be used with caution in patients with oedema, should not be used in those with a history of heart failure. , Rosiglitazone should also be avoided in patients having an acute coronary event because this condition has the potential to precipitate heart failure. ,
Ref :-   Book : Martindale    Page : 498   Edition : 37,
  ►  Mechanism of Action :   Bind and stimulate the nuclear harmone receptor peroxisome proliferator-activated receptor-γ ( PPAR γ), thereby increasing insulin sensitivity in adipose tissue, liver, and muscle,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 540   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Fenugreek seed with Another pathway, Blue Berries with Another pathway, Stevia with Another pathway,

  ►  Pathway with its reference as follows :-
  • 4 hydroxy isoleucine have antidiabetic effect --- ( Li, Y. & Perera, P. (2012). Functional herbal food ingredients used in type 2 diabetes mellitus. Pharmacognosy Reviews, 6(11), 37 )
  • Antidiabetic Effect --- (Stull, A. (2010). Bioactives in Blueberries Improve Insulin Sensitivity in Obese, Insulin-Resistant Men and Women. The Journal Of Nutrition, 140(10), 1764–1768 )
  • Stevioside have Antidiabetic Effect --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- Li, Y. & Perera, P. (2012). Functional herbal food ingredients used in type 2 diabetes mellitus. Pharmacognosy Reviews, 6(11), 37, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139238/, http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- ST JOHNS WORT with Dietary Substance is Drug Inhibitor,

      ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal, Renal,
    Ref :-   Book : Martindale    Page : 499   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   3 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 499   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 499   Edition : 37,