Rosuvastatin is a Medicine belongs to Drugs Used in Dyslipidemia group whose information about Brand can be referenced from   Book : Martindale    Page : 1525   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Razel,Rosuvas,Crestor,Razel-A,Roseday

  ►  Strength : Tablet with 5  mg, Tablet with 10  Mg, Tablet with 20  mg, Tablet with 40  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 633   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1461   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Dyslipidaemia Oral 5 10 mg Tablet o.d.
2 Familial hypercholesterolaemia Oral 20 mg Tablet o.d. The dose should be adjusted after 2 to 4 weeks, to a usual maximum of 20 mg once daily; a dose of 40 mg once daily may be necessary in some patients.
3 Myopathy Oral 5 mg Tablet

Ref :-  Book : Martindale    Page : 1525   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Management of heterozygous Familial hypercholesterolemia Oral 5 mg Tablet o.d.

Ref :- Book : Martindale    Page : 1525   Edition : 37,
Precaution :- If a Patient is using 'Rosuvastatin' drug in acute kidney injury disease, then Please use with caution   if he ever suffered from acute myocardial infarction disease.
►  Side Effect : gastrointestinal disturbance, headache, Skin rashes, Dizziness, Blurred Vision, insomnia, Dysgeusia, hepatitis, Pancreatitis, hypersensitivity reactions, anaphylaxis, angioedema, myopathy, myalgia, muscle weakness, increased creatine phosphokinase concentrations, ,
Ref :-   Book : Martindale    Page : 1524,1526   Edition : 37,

►  Drug Interaction : Drug interaction of Rosuvastatin is with , HIV- protease inhibitors,  Gemfibrozil ,
Ref :-   Book : Martindale    Page : 1524   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Rosuvastatin undergoes limited metabolism, principally by the cytochrome P450 isoenzyme CYP2C9, and may not have the same interactions with enzyme inhibitors as simvastatin. However, increased plasma-rosuvastatin concentrations have been reported with ciclosporin, HIV-protease inhibitors, eltrobopag, and, to a lesser extent, with gemfibrozil, and if such combinations cannot be avoided lower doses of rosuvastatin should be used. ,
Ref :-   Book : Martindale    Page : 1524   Edition : 37,


►  Contraindication : Active liver disease, Pregnancy, It should be used with caution in patients at risk of rhabdomyolysis, It should be used with caution in patients with renal impairment as the risk of myopathy is increased,
Ref :-   Book : Martindale    Page : 1524,1527-1528   Edition : 37,
  ►  Mechanism of Action :   Inhibit HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis→LDL decreases up to 60%, HDl increases ̴10% Triglycerides decreases upto 40%. ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 330   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- IRON with Dietary Substance is Drug Inhibitor,

  ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- COQ10 with Impairs coenzyme Q10 metabolism .,

      ►  Reference :-
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- http://197.14.51.10:81/pmb/AGROALIMENTAIRE/Handbook%20of%20Nutrition.pdf,

    ►   Route of Elimination :   Renal, Faecal,
    Ref :-   Book : Martindale    Page : 1525   Edition : 37,


    ►    Plasma Half-life :   Min value :-   19 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1525   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   5 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1525   Edition : 37,