Roxatidine is a Medicine belongs to H2 histamine receptor blockers group whose information about Brand can be referenced from   Book : Martindale    Page : 1924   Edition : 37,

  ►   Brandname : Rotane

  ►  Strength : Tablet with 75  mg, Tablet with 150  mg, Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1924   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 1924   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Peptic ulcer Oral 150 mg Tablet Dose: Given at bedtime or 75 mg twice daily for 4 to 6 weeks. Where appropriate a maintenance dose of 75 mg at bedtime may be given to prevent the recurrence of ulcers.
2 Gastro-oesophageal reflux disease Oral 150 mg Tablet Dose: Given at bedtime or 75 mg twice daily for 6 to 8 weeks.
3 Gastritis Oral 75 mg Tablet o.d. Dose: Given in the evening.
4 Zollinger-ellison syndrome Oral 75 mg Tablet b.d.
5 Pre-anaesthetic medication Slow IV 75 mg Injection Dose: Given 1 hour before anaesthesia.
6 Pre-anaesthetic medication Oral 75 mg Tablet Dose: Given in the evening on the day before surgery and repeated 2 hours before the induction of anaesthesia; alternatively a single dose of 150 mg may be given the night before surgery.
7 Upper gastrointestinal tract haemorrhage IV 75 mg Injection b.d.
8 Upper gastrointestinal tract haemorrhage IV infusion 75 mg Injection b.d.

Ref :-  Book : Martindale    Page : 1924   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Gastrointestinal disturbances, Dizziness, diarrhoea, Tiredness, headache, Rashes, myalgia, arthralgia, altered liver function tests, ,
Ref :-   Book : Martindale    Page : 1866,1923   Edition : 37,

►  Drug Interaction : Drug interaction of Roxatidine is with Dasatinib, Ketoconazole , Itraconazole , Posaconazole ,
Ref :-   Book : Martindale    Page : 1868,1923   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Roxatidine and other H2-antagonists can reduce the absorption of drugs such as dasatinib, ketoconazole, and possibly itraconazole, whose absorption is dependent on an acid gastric pH. Roxatidine does not appear to affect cytochrome P450, and therefore is considered to have little effect on the metabolism of other drugs. However, like other H2-antagonists its effects on gastric pH may alter the absorption of some other drugs.,
Ref :-   Book : Martindale    Page : 1868,1923   Edition : 37,


►  Contraindication : Before giving roxatidine or other histamine H2-antagonists to patients with gastric ulcers the possibility of malignancy should be considered since these drugs may mask symptoms and delay diagnosis. They should be given in reduced dosage to patients with renal impairment., Intravenous injections of roxatidine should be given slowly and intravenous infusion is preferred, particularly for high doses and in patients with cardiovascular impairment.,
Ref :-   Book : Martindale    Page : 1868,1923   Edition : 37,
  ►  Mechanism of Action :   The H2 receptor antagonists inhibit acid production by reversibly competing with histamine for binding to H2 receptors on the basolateral membrane of parietal cells. ,
Ref :-   Book : Goodman    Page : 1313   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 1924   Edition : 37,


►    Plasma Half-life :
  Min value :-   4 hours,    Max value :-   6 hours,
Ref :-   Book : Martindale    Page : 1924   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   4 hours,
Ref :-   Book : Martindale    Page : 1924   Edition : 37,