Roxatidine is a Medicine belongs to H2?receptor blocker group whose information about Brand can be referenced from   Book : Martindale    Page : 1924   Edition : 37,

  ►   Brandname : Rotane

  ►  Strength : Tablet with 75  mg, Tablet with 150  mg,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1924   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 1924   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Peptic ulcer Oral 150 mg Tablet h.s.
2 Peptic ulcer Oral 75 mg Tablet b.d.
3 Gastro-oesophageal reflux disease Oral 150 mg Tablet h.s.
4 Gastro-oesophageal reflux disease Oral 75 mg Tablet b.d.
5 Gastritis Oral 75 mg Tablet o.d.
6 Zollinger-ellison syndrome Oral 75 mg Tablet b.d.
7 Pre-anaesthetic medication IV 75 mg Injection Dose: Given 1 hour before anaesthesia.
8 Pre-anaesthetic medication Oral 75 mg Tablet Dose: Given in the evening on the day before surgery.
9 Upper gastrointestinal tract haemorrhage IV 75 mg Injection b.d.
10 Upper gastrointestinal tract haemorrhage IV infusion 75 mg Injection b.d.

Ref :-  Book : Martindale    Page : 1924   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : diarrhea, gastrointestinal disturbance, Dizziness, Tiredness, headache, Rashes, altered liver function tests, renal failure, hypersensitivity reactions, arthralgia, myalgia, agranulocytosis, leucopenia, thrombocytopenia, acute pancreatitis, interstitial nephritis, hallucinations, Depression, bradycardia, tachycardia, heart block, chronic lung disease, pneumonia, diabetes mellitus,
Ref :-   Book : Martindale    Page : 1866,1923,1924   Edition : 37,

►  Drug Interaction : Drug interaction of Roxatidine is with Sildenafil , Dasatinib, Ketoconazole , Itraconazole , Posaconazole ,
Ref :-   Book : Martindale    Page : 1868, 1924   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Roxatidine can reduce the absorption of drugs such as dasatinib, ketoconazole, itraconazole, and possibly posaconazole whose absorption is dependent on an acid gastric pH.,
Ref :-   Book : Martindale    Page : 1868   Edition : 37,


►  Contraindication : Gastric malignancies,
Ref :-   Book : Martindale    Page : 1830   Edition : 38,
  ►  Mechanism of Action :   The H2 receptor antagonists inhibit acid production by reversibly competing with histamine for binding to H2 receptors on the basolateral membrane of parietal cells. ,
Ref :-   Book : Goodman    Page : 1313   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 1924   Edition : 37,


►    Plasma Half-life :
  Min value :-   4 hours,    Max value :-   6 hours,
Ref :-   Book : Martindale    Page : 1924   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   4 hours,
Ref :-   Book : Martindale    Page : 1924   Edition : 37,