Roxithromycin is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 360   Edition : 37  

  ►   Brandname : Biaxsig, Roxar, Roximycin, Rulide, Infectoroxit, Romyk, Roxi, Biorox, Roxee, Roxem
  ►  Strength : Tablet with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 359   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 360   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Susceptible infections Oral 150 mg b.d. Dose: sometimes 300 mg once daily, at least 15 minutes before meals, for 5 to 10 days

Ref :-  Book : Martindale    Page : 360   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Susceptible infections 6 to 40 kg Oral 5 8 mg/kg

Ref :- Book : Martindale    Page : 360   Edition : 37  
►  Side Effect : Gastrointestinal disturbances, Abdominal discomfort, Cramps, Nausea, Vomiting, Diarrhoea, Pseudomembranous colitis, Hypersensitivity reactions, pruritus, Urticaria, Skin rashes, Anaphylaxis, Cholestasis, Jaundice, Rashes, Fever, Eosinophilia, Agranulocytosis, Pancreatitis, QT interval prolongation, Torsade de pointes, Confusion, Hallucinations, Seizures, Vertigo, Upper abdominal pain, Abnormal liver function values, Aggravation of muscular weakness in myasthenia gravis patients
Ref :-   Book : Martindale    Page : 293,359   Edition : 37.  

►  Drug Interaction : Drug interaction of Roxithromycin is with Astemizole, Cisapride , Terfenadine, Spiramycin , Levodopa , Theophylline
Ref :-   Book : Martindale    Page : 295,359   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  Roxithromycin has a much lower affinity for cytochrome P450 isoenzymes than erythromycin and therefore has fewer interactions. It does not appear to interact with antacids, carbamazepine, oral contraceptives, prednisolone, or ranitidine. Roxithromycin and other macrolides have the potential to interact with a large number of drugs through their action on hepatic cytochrome P450 isoenzymes, particularly CYP1A2 and CYP3A4. Macrolides inhibit drug metabolism by microsomal cytochromes by competitive inhibition and by the formation of inactive complexes. Such interactions can result in severe adverse effects, including ventricular arrhythmias with them. Macrolides-induced inhibition of metabolism can result in severe adverse effects, including ventricular arrhythmia with astemazole, cisapride, and terfenadine. Other mechanisms by which macrolides cause interactions include suppression of the gastrointestinal flora responsible for the intraluminal metabolism of digoxin and possibly oral contraceptives, and the stimulant effect of macrolides on gastrointestinal motility which is believed to be responsible for the interaction between spiramycin and levodopa. An alternative mechanism by which macrolides increase serum concentrations of digoxin is thought to be via the inhibition of intestinal or renal P-glycoprotein transport of digoxin. Few drugs are reported to affect roxithromycin but cimetidine may increase and theophylline may decrease roxithromycin concentrations.
Ref :-   Book : Martindale    Page : 295,356   Edition : 37.  

►  Contraindication : Renal impairment, It should be avoided in those known to be hypersensitive to it, or in those who have previously developed jaundice., It may aggravate muscle weakness in patients with myasthenia gravis, It should be used with care in patients with a history of arrhythmias or a predisposition to QT interval prolongation.
Ref :-   Book : Martindale    Page : 293,359   Edition : 37.  
  ►  Mechanism of Action :   It is a bacteriostatic agent that inhibit protein synthesis by binding reversibly to 50S ribosomal subunits of sensitive microorganisms, at or very near the site that binds chloramphenicol.
Ref :-   Book : Goodman    Page : 1530   Edition : 12.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism), Renal, Faecal, Lungs
Ref :-   Book : Martindale    Page : 359   Edition : 37.  

►    Plasma Half-life :   Min value :-   8 hours,    Max value :-   13 hours.  
Ref :-   Book : Martindale    Page : 359   Edition : 37.  

►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 359   Edition : 37.