Salmeterol is a Medicine belongs to Bronchodilator/Anti-asthma Drugs group whose information about Brand can be referenced from   Book :    Page :   Edition : , Martindale    Page : 1225   Edition : 38,

  ►   Brandname : Seroflo,Seroflo rotacap,Azrol, Salmeter, Serobid, Neovent, Serevent

  ►  Strength : inhalant powder with 50  mcg/unit, Aerosol with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 355   Edition : 12, Martindale    Page : 1224   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : inhalation,
Reference :-   Book : Martindale    Page : 1224   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Persistent reversible airways obstruction, as in chronic asthma or in some patients with chronic obstructive pulmonary disease. inhalation 50 mcg/unit Aerosol or dry powder inhaler b.d. Useful in protecting against nocturnal and exercise-induced asthma attacks; If necessary, up to 100 microgram may be inhaled twice daily.

Ref :-  Book : Martindale    Page : 1224   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 For persistent reversible airways obstruction which requires regular bronchodilatation, including nocturnal asthma and prevention of exercise-induced asthma. 4 Year 12 Year inhalation 50 Microgram dry powder inhaler b.d.

Ref :- Book : Martindale    Page : 1224   Edition : 38,
►  Side Effect : paradoxical bronchospasm, Fine tremor of skeletal muscle (particularly the hands),, palpitations, tachycardia, nervous tension, headache, peripheral vasodilatation, hypokalaemia, myocardial ischaemia, hypersensitivity reactions, bronchospasm, angioedema, Urticaria, hypotension, collapse, ,
Ref :-   Book : Martindale    Page : 1224   Edition : 38, Martindale    Page : 1224,1221   Edition : 38,

►  Drug Interaction : Drug interaction of Salmeterol is with , Corticosteroid , Diuretics, Xanthines,  Ketoconazole , Erythromycin ,
Ref :-   Book : Martindale    Page : 1225   Edition : 38, Martindale    Page : 1225,1223   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Salmeterol is metabolized by the cytochrome P450 isoenzyme CYP3A4 and used with oral ketoconazole has resulted in an increased systemic exposure to inhaled salmeterol with the potential to increase adverse effects; similar interactions could occur with other potent inhibitors of CYP3A4.Use of salmeterol with erythromycin a moderate inhibitor of CYP3A4. Use of salbutamol and other beta2 agonists with corticosteroids, diuretics, or xanthines increases the risk of hypokalaemia, and monitoring of potassium concentrations is recommended in severe asthma, ,
Ref :-   Book : Martindale    Page : 1225,1223   Edition : 38,


►  Contraindication : patients who are not also receiving an inhaled corticosteroid.,
Ref :-   Book : Martindale    Page : 1224   Edition : 38,
  ►  Mechanism of Action :   Salmeterol is a direct-acting sympathomimetic with beta-adrenoceptor stimulant activity and a selective action on beta2 receptors (a beta2 agonist).,
Ref :-   Book : Martindale    Page : 1224   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Faecal, Hepatic (Metabolism),
Ref :-   Book : Martindale    Page : 1225   Edition : 38,


►    Plasma Half-life :
  Min value :-   NA    Max value :-   NA


►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA