Saquinavir is a Medicine belongs to Antiviral group whose information about Brand can be referenced from   Book : Martindale    Page : 1001   Edition : 37,

  ►   Brandname : Saquin,Maximune,Invirase

  ►  Strength : Tablet with 500  mg, Capsule with 200  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 889   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1001   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 HIV infection Oral 1 gm b.d. Given with ritonavir 100 mg twice daily with or after food.

Ref :-  Book : Martindale    Page : 1002   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : nausea, vomiting, diarrhea, abdominal discomfort, lipodystrophy,
Ref :-   Book : Martindale    Page : 1001   Edition : 37,

►  Drug Interaction : Drug interaction of Saquinavir is with Rifampicin , Phenytoin , Carbamazapine ,
Ref :-   Book : Martindale    Page : 1001.1   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Saquinavir is reported to be metabolised by the cytochrome P450 system, with the specific isoenzyme CYP3A4 responsible for more than 90% of the hepatic metabolism. Saquinavir is also a substrate and an inhibitor of P-glycoprotein. Drugs that affect this isoenzyme and/or P-glycoprotein may modify saquinavir plasma concentrations,
Ref :-   Book : Martindale    Page : 1001   Edition : 37,


►  Contraindication : Drugs that are highly dependent on CYP3A4 for clearance, ,
Ref :-   Book : Martindale    Page : 1001   Edition : 37,
  ►  Mechanism of Action :   Saquinavir is a selective, competitive, reversible inhibitor of HIV-1 and HIV-2 protease. It interferes with the formation of essential viral proteins making them incapable of infecting other cells,
Ref :-   Book : Martindale    Page : 1001   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- CATS CLAY with Dietary Substance is Drug Enhancer,

  ►  Reference :-
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- FURANOCOUMARIN with grape fruit & celery contain furanocumarin increase Saquinavir level .s,

      ►  Reference :-
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,

    ►   Route of Elimination :   Biliary, Fecal, Renal,
    Ref :-   Book : Martindale    Page : 1001   Edition : 37,


    ►    Plasma Half-life :   Min value :-   1 hours,    Max value :-   2 hours,
    Ref :-   Book : Basic & Clinical pharmacology    Page : 1644   Edition : 12,


    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,