Saquinavir is a Medicine belongs to Antiviral group whose information about Brand can be referenced from   Book : Martindale    Page : 1015   Edition : 38  

  ►   Brandname : Invirase
  ►  Strength : Tablet with 500 mg.  Capsule with 200 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 889   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 1014   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 HIV infection and AIDS Oral 1 gm Tablet/Capsule b.d. Given with ritonavir 100 mg twice daily with or after food.

Ref :-  Book : Martindale    Page : 1014   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Antiretroviral therapy more than 2 Year 5 to less than 15 kg Oral 50 mg/kg + 3 mg/kg RTV Tablet/Capsule b.t.
2 Antiretroviral therapy 15 to 40 kg Oral 50 mg/kg + 2.5 mg/kg RTV Tablet/Capsule b.t.
3 Antiretroviral therapy more than 40 kg Oral 50 mg/kg + 100 mg/kg RTV Tablet/Capsule b.t.
4 Antiretroviral therapy Oral 1,000 mg + 100 mg RTV Tablet/Capsule b.t.

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1171   Edition : 19  
►  Side Effect : Gastrointestinal disorders, Abdominal pain, Diarrhoea, Flatulence, Nausea, Vomiting, Fatigue, Alopecia, Anaemia, Anorexia, Increased appetite, Asthenia, Constipation, Dizziness, Dry mouth, Dry skin, Dyspepsia, Dyspnoea, Eczema, Headache, Hypersenstivity, Decreased libido, Malaise, Muscle spasm, Paraesthesia, Peripheral neuropathies, pruritus, Rashes, Sleep disturbances, Taste disorders, Raised liver enzyme values, Increased blood amylase, bilirubin, and creatinine, Lowered haemoglobin and platelet, lymphocyte, and white blood cell count., , Accumulation or redistribution of body fat (lipodystrophy) including central obesity, dorsocervical fat enlargement (buffalo hump), peripheral wasting, facial wasting, breast enlargement, and cushingoid appearance, Hypertriglyceridaemia, Hypercholesterolaemia, Insulin resistance, Hyperglycaemia, Hyperlactataemia, Elevated creatine phosphokinase, Myalgia, Myositis, , Osteonecrosis
Ref :-   Book : Martindale    Page : 1014   Edition : 38.  

►  Drug Interaction : Drug interaction of Saquinavir is with , , ,  Amiodarone , Bepridil, Flecainide Acetate , Propafenone, Quinidine , Astemizole, Terfenadine, Rifampicin , Dihydroergotamine, Ergometrine , Ergotamine, Methylergometrine, Cisapride , Pimozide , Midazolam , Triazolam , Simvastatin , Lovastatin
Ref :-   Book : Martindale    Page : 1014   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  Saquinavir is reported to be metabolised by the cytochrome P450 system, with the specific isoenzyme CYP3A4 responsible for more than 90% of the hepatic metabolism. Saquinavir is also a substrate and an inhibitor mof P-glycoprotein. Drugs that affect this isoenzyme and/or P-glycoprotein may modify saquinavir plasma concentrations. Saquinavir may alter the pharmacokinetics of other drugs that are metabolised by this enzyme system or that are substrates for P-glycoprotein. Saquinavir is contra-indicated with drugs that are highly dependent on CYP3A4 for clearance and for which elevated plasma concentrations are associated with serious or life-threatening events. These drugs include antiarrhythmics (amiodarone, bepridil, flecainide, propafenone, and quinidine), antihistamines (astemizole and terfenadine), antimycobacterial (rifampicin), ergot derivatives (dihydroergotamine, ergometrine, ergotamine, methylergometrine), gastrointestinal prokinetics (cisapride), antipsychotics (pimozide), sedatives and hypnotics (midazolam and triazolam), and statins (simvastatin and lovastatin). St John’s wort decreases the concentration of saquinavir; use with the antiretroviral is not recommended due to the possible loss of its activity and development of resistance.
Ref :-   Book : Martindale    Page : 1014   Edition : 38.  


►  Contraindication : Saquinavir should not be used in patients with decompensated liver disease, Used with caution in patients with moderate hepatic or severe renal impairment, Caution is advised in treating patients with haemophilia A and B as reports of spontaneous bleeding have been associated with the use of HIV-protease inhibitors
Ref :-   Book : Martindale    Page : 1014   Edition : 38.  
  ►  Mechanism of Action :   Saquinavir is an HIV-protease inhibitor with antiviral activity against HIV
Ref :-   Book : Martindale    Page : 1014   Edition : 38.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- FURANOCOUMARIN with grape fruit & celery contain furanocumarin increase Saquinavir level .s.  

  ►  Reference :-
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf

    ►   Route of Elimination :   Hepatic (Metabolism)
    Ref :-   Book : Martindale    Page : 1014   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   1 hours,    Max value :-   2 hours.  
    Ref :-   Book : Martindale    Page : 1015   Edition : 38.  

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA