Saxagliptin is a Medicine belongs to Antidiabetic group whose information about Brand can be referenced from   Book : Martindale    Page : 500   Edition : 38  

  ►   Brandname : Onglyza
  ►  Strength : Tablet with 2.5 Mg.  Tablet with 5 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 766   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 499   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Type 2 diabetes mellitus Oral 2.5 mg Tablet o.d. Or 5 mg; Given with or without food.

Ref :-  Book : Martindale    Page : 499   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1

Ref :- Book :    Page :    Edition :   
►  Side Effect : Upper respiratory-tract-infection, Headache, Hypersensitivity reactions, Urticaria, Facial edema, Peripheral edema (when combined with a Thiazolidinedione), Hypoglycemia (when combined with a sulfonylurea)
Ref :-   Book : Basic & Clinical pharmacology    Page : 761   Edition : 12.  

►  Drug Interaction : Drug interaction of Saxagliptin is with , ,  Diltiazem , Ketoconazole , Rifampicin
Ref :-   Book : Martindale    Page : 499   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  The efficacy of saxagliptin may be affected by other drugs that have an independent effect on blood glucose. For more details and examples of drugs that can increase or decrease blood-glucose concentrations. Drugs that alter the activity of the cytochrome P450 isoenzymes CYP3A4 and CYP3A5 could affect the metabolism of saxagliptin. Dosage adjustment of saxagliptin is not thought necessary with moderate inhibitors of these enzymes, such as diltiazem, low doses of saxagliptin should be used when strong inhibitors such as Ketoconazole, are given with saxagliptin. The enzyme inducer Rifampicin can significantly decrease exposure to saxagliptin, but exposure to its active metabolites and plasma dipeptidylpeptidase-4 inhibition are not affected
Ref :-   Book : Martindale    Page : 499   Edition : 38.  


►  Contraindication : Type 1 diabetes mellitus, Diabetic ketoacidosis
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 539   Edition : 3.  
  ►  Mechanism of Action :   Saxagliptin is an inhibitor of the enzyme dipeptidylpeptidase-4, an enzyme responsible, among other roles, for the degradation of the incretin hormone glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide.
Ref :-   Book : Martindale    Page : 499,500   Edition : 38.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Berries with same pathway.  

  ►  Pathway with its reference as follows :-
  • DPP 4 inhibitor --- (Fan, J., Johnson, M., Lila, M., Yousef, G. and de Mejia, E. (2013). Berry and Citrus Phenolic Compounds Inhibit Dipeptidyl Peptidase IV: Implications in Diabetes Management. Evidence-Based Complementary and Alternative Medicine, 2013, pp.1-13. )

  •   ►  URL --
  • http://www.hindawi.com/journals/ecam/2013/479505/ .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Faecal, Renal
    Ref :-   Book : Martindale    Page : 499   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   Elimination half-lives of saxagliptine and its metabolite are about 2.5 and 3.1 hours respectively.,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 499   Edition : 38.  

    ►    Peak Plasma Concentration :   Min value :-   Peak Plasma Concentration occur within about 2 hours. It is metabolized mainly by the cytochrome P450 isoenzymes CYP3A4 and CYP3A5, and its major metabolite,5-hydoxy saxagliptin, has half the potency of Saxagliptin. Peak Plasma Concentration of this metabolite occur within about 4 hours.,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 499   Edition : 38.