Selegiline is a Medicine belongs to Antiparkinsonian Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 903   Edition : 37,

  ►   Brandname : Selerin,Selgin,Eldepryl,Zelapar,Atapryl,Carbex

  ►  Strength : Capsule with 5  mg, Tablet with 5  Mg, Tablet with 1.25  Mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 439   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Transdermal,
Reference :-   Book : Martindale    Page : 902   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Parkinson’s disease Oral 1.25 mg Tablet At least 5 minutes before breakfast.
2 Depression Topical 6 mg Transdermal Patch o.d.
3 Parkinson’s disease Oral 10 mg Daily.

Ref :-  Book : Martindale    Page : 902   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : chest pain, agitation, Confusion, constipation, Depression, diarrhea, Dizziness, hallucinations, nausea, Orthostatic hypotension, psychoses, vomiting, Cardiac arrhythmias, difficulty with micturition, dry mouth, joint pains, muscle cramps, myopathy, skin reaction,
Ref :-   Book : Martindale    Page : 901   Edition : 37,

►  Drug Interaction : Drug interaction of Selegiline is with Phenelzine, Tyramine, Venlafaxine , Pethidine,
Ref :-   Book : Martindale    Page : 902   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Selegiline is less likely than non-selective MAOIs, such as phenelzine, to interact with tyramine in food; Serious reactions, sometimes fatal, have also been reported when selegiline was used with tricyclic antidepressants or serotonin reuptake inhibitors including the SSRIs and venlafaxine. Use of selegiline with non-selective MAOIs may cause severe hypotension and such use is not recommended,
Ref :-   Book : Martindale    Page : 902   Edition : 37,


►  Contraindication : peptic ulcer disease, , Angina, Arrhythmia, hepatic dysfunction, renal disease, Psychosis,
Ref :-   Book : Martindale    Page : 902   Edition : 37,
  ►  Mechanism of Action :   Selegiline is an irreversible selective inhibitor of monoamine oxidase type B, an enzyme involved in the metabolic degradation of dopamine in the brain. It enhances the effects of levodopa and is used in the treatment of Parkinson’s disease mainly as an adjunct to levodopa therapy to reduce ‘end-of-dose’ or ‘on-off’ fluctuations in response,
Ref :-   Book : Martindale    Page : 902   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Banana with Another pathway, Ashwagandha with Another pathway, Fava beans i.e. bakla with same compound, Babchi with same pathway, Licorice with same pathway, Bakuchi with same pathway, Amur Cortree with same pathway, Passion flower with same pathway, Dictamnus albus with same pathway, Ginkgo biloba with same pathway, Zanthoxylum schinifolium i.e.Sichuan pepper. with same pathway, Hypericum with same pathway, Curcumin with same pathway, Madagascar periwinkle with same pathway, Vincristine with same pathway, Uncaria rhynchophylla with same pathway, Polygonium multiflora with same pathway, Netmeg with same pathway,

  ►  Pathway with its reference as follows :-
  • Withanine Increased Dopamine level --- (Kumar, K. (2012). Traditional and Medicinal Uses of Banana. Journal Of Pharmacognosy And Phytochemistry, 1(3). )
  • Ashwagandha increased Dopamine level --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • Fava beans rich in levo-dihydroxyphenylalanine(L-Dopa) the precursor of dopamine. --- (Mehran S.M., Mohseni. "Simultaneous Determination Of Levodopa And Carbidopa From Fava Bean, Green Peas And Green Beans By High Performance Liquid Gas Chromatography". JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH (2013): n. pag. Web. 10 Nov. 2016. )
  • Monoamine oxide inhibitor . --- (Mazzio, E. "High Throughput Screening To Identify Natural Human Monoamine Oxidase B Inhibitors". 27.6 (2013): 818-828. Web. 16 Nov. 2016. )
  • Monoamine oxide inhibitor . --- (Mazzio, E. "High Throughput Screening To Identify Natural Human Monoamine Oxidase B Inhibitors". 27.6 (2013): 818-828. Web. 16 Nov. 2016. )
  • Monoamine oxide inhibitor . --- (Mazzio, E. "High Throughput Screening To Identify Natural Human Monoamine Oxidase B Inhibitors". 27.6 (2013): 818-828. Web. 16 Nov. 2016. )
  • Monoamine oxide inhibitor . --- (Mazzio, E. "High Throughput Screening To Identify Natural Human Monoamine Oxidase B Inhibitors". 27.6 (2013): 818-828. Web. 16 Nov. 2016. )
  • Harmine active constituent of passion flower act as monoamine oxidase inhibitor. --- ( Rajput., Mithul Singh. "Natural Monoamine Oxidase Inhibitor ; A Review.". Journal of Pharmacy Research 3.3 (2010): 482-485-. Print. )
  • Dictamnus albus having actuive constituent cumarins act as monoamine oxidase inhibitor . --- (Rajput., Mithul Singh. "Natural Monoamine Oxidase Inhibitor ; A Review.". Journal of Pharmacy Research 3.3 (2010): 482-485-. Print. )
  • Ginkgo biloba having active constituent isorhamnetin act as monoamine oxidase inhibitor . --- (Rajput., Mithul Singh. "Natural Monoamine Oxidase Inhibitor ; A Review.". Journal of Pharmacy Research 3.3 (2010): 482-485-. Print. )
  • Sichuan pepper having active constituent lacinartin act as monoamine oxide inhibitor . --- (Rajput., Mithul Singh. "Natural Monoamine Oxidase Inhibitor ; A Review.". Journal of Pharmacy Research 3.3 (2010): 482-485-. Print. )
  • Hypericum perforatum having active constituent hypericin act as monoamineoxidase inhibitor. --- (Rajput., Mithul Singh. "Natural Monoamine Oxidase Inhibitor ; A Review.". Journal of Pharmacy Research 3.3 (2010): 482-485-. Print. )
  • Curcumin act as monoamine oxidase inhibitor . --- (Rajput., Mithul Singh. "Natural Monoamine Oxidase Inhibitor ; A Review.". Journal of Pharmacy Research 3.3 (2010): 482-485-. Print. )
  • Madagascar periwinkle having active constituent vinblastine act as monoamine oxidase inhibitor . --- (Rajput., Mithul Singh. "Natural Monoamine Oxidase Inhibitor ; A Review.". Journal of Pharmacy Research 3.3 (2010): 482-485-. Print. )
  • Vinca rosea having active constituent vincristine act as monoamine oxidase inhibitor . --- (Rajput., Mithul Singh. "Natural Monoamine Oxidase Inhibitor ; A Review.". Journal of Pharmacy Research 3.3 (2010): 482-485-. Print. )
  • Uncaria rhynchophylla having active constituent epicatechin act as monoamine oxidase inhibitor. --- (Rajput., Mithul Singh. "Natural Monoamine Oxidase Inhibitor ; A Review.". Journal of Pharmacy Research 3.3 (2010): 482-485-. Print. )
  • Polygonum multiflora act as monoamine oxidase inhibitor . --- (Rajput., Mithul Singh. "Natural Monoamine Oxidase Inhibitor ; A Review.". Journal of Pharmacy Research 3.3 (2010): 482-485-. Print. )
  • Netmeg having active constituent myristicin act as monoamine oxidase inhibitor. --- (Rajput., Mithul Singh. "Natural Monoamine Oxidase Inhibitor ; A Review.". Journal of Pharmacy Research 3.3 (2010): 482-485-. Print. )

  •   ►  URL -- http://www.phytojournal.com/vol1Issue3/Issue_sept_2012/9.1.pdf, http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708185/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521852, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521852/, https://www.researchgate.net/publication/41805982_Natural_Monoamine_oxidase_inhibitors_A_Review,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- 5 HTP(5-HYDROXYTRYPTOPHAN) with Dietary Substance is Drug Enhancer, TRYPTOPHAN with Dietary Substance is Drug Enhancer,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf, http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NIACIN with Niacin enhance hypoglycemic action ., CHEESE with Aged cheese rich in tyramine should be avoided ., RED WINE with Red wine rich in tyramine should be avoided ., FAVA BEANS I.E. BAKLA with Fava beans rich in tyramine should be avoided ., YEAST with Yeast rich in tyramine should be avoided ., PICKLED FISH with Pickled fish rich in tyramine should be avoided .,

      ►  Reference :-
  • YAHEYA, MOHAMMAD. "DRUG-FOOD INTERACTIONS AND ROLE OF PHARMACIST". Asian Journal of Pharmaceutical and Clinical Research 2.4 (2009): n. pag. Print.
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • YAHEYA, MOHAMMAD. "DRUG-FOOD INTERACTIONS AND ROLE OF PHARMACIST". Asian Journal of Pharmaceutical and Clinical Research 2.4 (2009): n. pag. Print.
  • YAHEYA, MOHAMMAD. "DRUG-FOOD INTERACTIONS AND ROLE OF PHARMACIST". Asian Journal of Pharmaceutical and Clinical Research 2.4 (2009): n. pag. Print.
  • YAHEYA, MOHAMMAD. "DRUG-FOOD INTERACTIONS AND ROLE OF PHARMACIST". Asian Journal of Pharmaceutical and Clinical Research 2.4 (2009): n. pag. Print.
  • YAHEYA, MOHAMMAD. "DRUG-FOOD INTERACTIONS AND ROLE OF PHARMACIST". Asian Journal of Pharmaceutical and Clinical Research 2.4 (2009): n. pag. Print.
  • YAHEYA, MOHAMMAD. "DRUG-FOOD INTERACTIONS AND ROLE OF PHARMACIST". Asian Journal of Pharmaceutical and Clinical Research 2.4 (2009): n. pag. Print.

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf, http://ajpcr.com/Vol2Issue4/226.pdf,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 902   Edition : 37,


    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA