Senna is a Medicine belongs to Laxative group whose information about Brand can be referenced from   Book : Martindale    Page : 1925   Edition : 37,

  ►   Brandname : Senade,Senalax,Senokot,Dosaflex

  ►  Strength : Tablet with 8.6  mg, Tablet with 15  mg, Tablet with 17  mg, Tablet with 25  mg, Solution with 8.8  mg/ml, Solution with 15  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 1112   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 1112   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Bowel evacuation Oral 105 157.5 mg Oral liquid
2 Constipation Oral 15 30 mg Tablet h.s. As a single dose.

Ref :-  Book : Martindale    Page : 1925   Edition : 37, Martindale    Page : 1885   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Constipation 2 Year 6 Year Oral 3.75 7.5 mg Tablet o.d.
2 Constipation 6 Year 12 Year Oral 7.5 15 mg Tablet o.d.
3 Constipation 12 Year <12 Year Oral 15 30 mg Tablet o.d.

Ref :- Book : Martindale    Page : 1925   Edition : 37,
►  Side Effect : abdominal discomfort, diarrhea, excessive loss of water and electrolyte,
Ref :-   Book : Martindale    Page : 1924   Edition : 37,

►  Drug Interaction : Drug interaction of Senna is with NA

  ►    Mechanism of Drug Drug Interaction :  NF,
Ref :-   Book :    Page :    Edition : ,


►  Contraindication : inflammatory bowel disease, Hypersensitivity,
Ref :-   Book : Martindale    Page : 1924   Edition : 37,
  ►  Mechanism of Action :   Senna (STIMULANT LAXATIVE) induce bowel movements through a number of poorly understood mechanisms. These include direct stimulation of the enteric nervous system and colonic electrolyte and fluid secretion,
Ref :-   Book : Basic & Clinical pharmacology    Page : 1093   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- senna leaves with same compound, Angeer with Another pathway,

  ►  Pathway with its reference as follows :-
  • The breakdown products of senna act directly as irritants on the colonic wall to induce fluid secretion and colonic motility --- (Kokate, C. (2013). Pharmacognosy. Pune: Nirali Prakashan. )
  • Angeer having soluble fiber pectin stimulate healthy bowel movement, laxative effect . --- ( Joseph, Baby. "Pharmacognostic And Phytochemical Properties Of Ficus Carica Linn –An Overview". International Journal of PharmTech Research 3.1 (2017): 08-12,. Print. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html, http://sphinxsai.com/Vol.3No.1/pharm_jan-mar11/pdf/JM11(%20PT=03)%2008-12.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- SODIUM with Increase in Nutrient Level, POTASSIUM with Decrease in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal, Renal,
    Ref :-   Book : Martindale    Page : 1925   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   6 hours,    Max value :-   12 hours,
    Ref :-   Book : Martindale    Page : 1924   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,