Sertraline is a Medicine belongs to Antidepressant group whose information about Brand can be referenced from   Book : Martindale    Page : 449   Edition : 38,    Page :   Edition : ,

  ►   Brandname : Inosert,Serdep,Serta,Xsert,Lustral,Zoloft,Zosert

  ►  Strength : Tablet with 25  Mg, Tablet with 50  Mg, Tablet with 100  Mg, Solution with 20  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 539   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 448   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Depression Oral 50 mg Tablet Daily, if necessary, in increments of 50 mg at intervals of at least a week to a maximum of 200 mg daily.
2 Obsessive-compulsive disorder Oral 50 mg Tablet Daily.
3 Social anxiety disorder and post-traumatic stress disorder Oral 25 mg Tablet Daily, increased after one week to 50 mg daily.
4 Premenstrual dysphoric disorder Oral 50 mg Tablet Daily either throughout the menstrual cycle or during the luteal phase only, as appropriate. Doses may be increased by 50 mg each menstrual cycle up to a maximum of 150 mg daily for continuous dosing or 100 mg daily when dosing during the luteal phase only. Those patients who require 100 mg daily during luteal phaseonly dosing should initially be given 50 mg daily for the first 3 days of each luteal phase dosing period.

Ref :-  Book : Martindale    Page : 448   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Depression 12 Year Over 12 Year Oral 50 mg Tablet
2 Obsessive-compulsive disorder 6 Year 12 Year Oral 25 mg Tablet o.d.
3 Obsessive-compulsive disorder Oral 50 mg Tablet o.d.

Ref :- Book : Martindale    Page : 448   Edition : 38,
►  Side Effect : menstrual irregularities, , dry mouth, gastrointestinal disturbance, nausea, vomiting, dyspepsia, diarrhoea, anorexia, constipation, weight loss, anxiety, Restlessness, Nervousness, insomnia, drowsiness, fatigue, headache, tremor, Dizziness, seizure, hallucinations, Confusion, agitation, extrapyramidal effects, depersonalisation, mania, panic attacks, sexual dysfunction, excess sweating, pruritus, Rashes, alopecia, photosensitivity, Urticaria, angioedema, Anaphylactoid reactions, serotonin syndrome,
Ref :-   Book : Martindale    Page : 448   Edition : 38, Martindale    Page : 448, 419   Edition : 38,

►  Drug Interaction : Drug interaction of Sertraline is with , , Monoamine Oxidase Inhibitor,  NA

  ►    Mechanism of Drug Drug Interaction :  Sertraline interact with other drugs mainly as a result of their inhibitory activity on hepatic cytochrome P450 isoenzymes. Individual Sertraline do not all exhibit the same degree of inhibition nor do they react with the same isoenzymes. Sertraline have occasionally been associated with bleeding disorders and other effects on the blood, caution is advised when they are given with drugs known to affect platelet function. Sertraline should not generally be given to patients receiving MAOIs or for at least 2 weeks after their use. No treatment-free period is necessary after stopping a reversible inhibitor of monoamine oxidase type A (RIMA) and starting an Sertraline. At least one week should elapse between withdrawing an SSRI and starting any drug liable to provoke a serious reaction (e.g. phenelzine); in the case of the SSRI sertraline the drug-free interval is extended to 2 weeks, and for fluoxetine 5 weeks, because of their longer half-lives.,
Ref :-   Book : Martindale    Page : 448,424   Edition : 38,


►  Contraindication : hepatic impairment, renal impairment,
Ref :-   Book : Martindale    Page : 448   Edition : 38,
  ►  Mechanism of Action :   Sertraline, is a selectively inhibit reuptake of serotonin and thereby increase synaptic serotonin levels; also cause increased 5-HT receptor activation and enhanced postsynaptic responses. At high doses, also bind NE transporter.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 221   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- BELLADONNA with Increasing anticholinergic activity of tricyclic antidepressants ., EPIMEDIUM I.E. EPIMEDIUM BREVICORNU with inhibit CYP2D6,

  ►  Reference :-
  • Duke, J. (2002). Handbook of Medicinal Herbs (2nd ed.). Boca Raton London New York Washington ,D.C.
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.

  •   ►  URL -- http://www.crcnetbase.com/doi/pdf/10.1201/9781420040463.fmatt, https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,

    ►   Route of Elimination :   Fecal, Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 448   Edition : 38,


    ►    Plasma Half-life :   Min value :-   26 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 448   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   4.5 ,    Max value :-   8.4 hours,
    Ref :-   Book : Martindale    Page : 448   Edition : 38,