Sevoflurane is a Medicine belongs to General anaesthetics group whose information about Brand can be referenced from   Book : Martindale    Page : 1914   Edition : 38  

  ►   Brandname : Ultane, Sojourn, Sevorane
  ►  Strength : Liquid with 250 ML. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 446   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : inhalation
Reference :-   Book : Martindale    Page : 1913   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 For the induction in premedicated patients inhalation 5 % Liquid With oxygen or a mixture of oxygen and nitrous oxide.
2 For the induction in unpremedicated patients inhalation Up to 8 % Liquid

Ref :-  Book : Martindale    Page : 1913   Edition : 38  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 For the induction in premedicated patients inhalation Up to 7 % Liquid

Ref :- Book : Martindale    Page : 1913   Edition : 38  
►  Side Effect : Cardiorespiratory depression, Hypotension, Malignant hyperthermia, Laryngospasm, Urinary retention, Increased cough and salivation, Acute renal failure, Seizure, Changes in liver enzyme values and reports of liver damage, Shivering, Nausea, Vomiting, Involuntary muscle movements, Hiccup, Bronchospasm, Apnoea, Cardiac arrhythmia, Mild hypothermia, Anorexia, Regurgitation and aspiration of gastric contents, Mortality, Drowsiness and impaired mental performance for at least 24 hours, Antiemetic prophylaxis, Malaise, Fatigue, Dizziness, Headache, Delirium, Dry mouth, , Muscle pain, typically involving the neck, shoulders, and upper abdomen, Hepatotoxicity
Ref :-   Book : Martindale    Page : 1913   Edition : 38.   Martindale    Page : 1913,1896   Edition : 38.  

►  Drug Interaction : Drug interaction of Sevoflurane is with sympathomimetic , Alcohol,  Adrenaline, Atracurium , Isoniazid
Ref :-   Book : Martindale    Page : 1913   Edition : 38.  

  ►    Mechanism of Drug Drug Interaction :  Care is advised if adrenaline or other sympathomimetics are given during sevoflurane anaesthesia. The effects of competitive neuromuscular blockers such as atracurium are enhanced by sevoflurane. The metabolism, and hence toxicity, of sevoflurane may be increased by drugs or compounds that induce cytochrome P450 isoenzyme CYP2E1 including isoniazid and alcohol.
Ref :-   Book : Martindale    Page : 1913   Edition : 38.  

►  Contraindication : Suspected susceptibility to malignant hyperthermia should not be anaesthetised with sevoflurane, With a history of moderate or severe hepatic impairment, Underlying liver disease, Caution in obstetrics, Caution together with techniquies to lower intracranial pressure
Ref :-   Book : Martindale    Page : 1913   Edition : 38.  
  ►  Mechanism of Action :   General anesthetics, mechanism of action remains unknown. In recent years this “unitary theory” of anesthetic action has been supplanted by a more complex picture of molecular targets located at multiple levels of the central nervous system (CNS). Anesthetics affect neurons at various cellular locations, but the primary focus has been on the synapse. A presynaptic action may alter the release of neurotransmitters, whereas a postsynaptic effect may change the frequency or amplitude of impulses exiting the synapse.
Ref :-   Book : Basic & Clinical pharmacology    Page : 429   Edition : 12.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- ALOE VERA with Aloe vera gel extracts inhibit platelet aggergation by inhibiting thromboxane A2,& aloe vera affects prostaglandin synthesis,which impair platelet aggregation .Therefore additive antiplatelet effect contributed to excessive bleeding .rostaglandin .  

  ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

  •   ►  URL --

    ►   Route of Elimination :   Hepatic (Metabolism), Renal
    Ref :-   Book : Martindale    Page : 1914   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA