Sevoflurane is a Medicine belongs to Inhaled anesthetics group whose information about Brand can be referenced from   Book : Martindale    Page : 1951   Edition : 37,

  ►   Brandname : Ultane,Sojourn

  ►  Strength : Inhalant with 250  ML,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 446   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : inhalation,
Reference :-   Book : Martindale    Page : 1950   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Anaesthesia inhalation 5 % Volatile Liquid

Ref :-  Book : Martindale    Page : 1913   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Anaesthesia inhalation 7 % Volatile Liquid

Ref :- Book : Martindale    Page : 1950   Edition : 37,
►  Side Effect : Cardiorespiratory depression, hypotension, Malignant hyperthermia, agitation, laryngospasm, increased salivation, Acute renal failure, shivering, nausea, vomiting,
Ref :-   Book : Martindale    Page : 1950   Edition : 37,

►  Drug Interaction : Drug interaction of Sevoflurane is with Adrenaline, Atracurium , Isoniazid , Zonisamide ,
Ref :-   Book : Martindale    Page : 1950   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The metabolism, and hence toxicity, of sevoflurane may be increased by drugs or compounds that induce cytochrome P450 isoenzyme CYP2E1 including isoniazid and alcohol.The effects of competitive neuromuscular blockers such as atracurium are enhanced by sevoflurane,
Ref :-   Book : Martindale    Page : 1950   Edition : 37,


►  Contraindication : , raised intracranial pressur,
Ref :-   Book : Martindale    Page : 1950`   Edition : 37,
  ►  Mechanism of Action :   General anesthetics, mechanism of action remains unknown. In recent years this “unitary theory” of anesthetic action has been supplanted by a more complex picture of molecular targets located at multiple levels of the central nervous system (CNS). Anesthetics affect neurons at various cellular locations, but the primary focus has been on the synapse. A presynaptic action may alter the release of neurotransmitters, whereas a postsynaptic effect may change the frequency or amplitude of impulses exiting the synapse. At the organ level, the effect of anesthetics may result from strengthening inhibition or from diminishing excitation within the CNS. Studies on isolated spinal cord tissue have demonstrated that excitatory transmission is impaired more strongly by anesthetics than inhibitory effects are potentiated. Chloride channels (γ-aminobutyric acid-A [GABA A ] and glycine receptors) and potassium channels (K 2P , possibly K v , and K ATP channels) remain the primary inhibitory ion channels considered legitimate candidates of anesthetic action. Excitatory ion channel targets include those activated by acetylcholine (nicotinic and muscarinic receptors), by excitatory amino acids (amino-3-hydroxy-5-methyl- 4-isoxazol-propionic acid [AMPA], kainate, and N -methyl- D - aspartate [NMDA] receptors), or by serotonin (5-HT 2 and 5-HT 3 receptors).,
Ref :-   Book : Basic & Clinical pharmacology    Page : 429, 430   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- ALOE VERA with Aloe vera gel extracts inhibit platelet aggergation by inhibiting thromboxane A2,& aloe vera affects prostaglandin synthesis,which impair platelet aggregation .Therefore additive antiplatelet effect contributed to excessive bleeding .rostaglandin ,

  ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,

    ►   Route of Elimination :   lungs,
    Ref :-   Book : Martindale    Page : 1950   Edition : 37,


    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA