Sildenafil is a Medicine belongs to Erectile Dysfunction group whose information about Brand can be referenced from   Book : Martindale    Page : 2399   Edition : 37,

  ►   Brandname : Caverta,Fiagra,Juan,Penegra,Silagra,Viagra

  ►  Strength : Tablet with 20  mg, Tablet with 25  mg, Tablet with 50  mg, Tablet with 100  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 209   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 2398   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Erectile dysfunction Oral 50 mg Tablet one hour before sexual intercourse.
2 Erectile dysfunction Oral 25 mg Tablet For patients over 65 years of age.
3 Pulmonary arterial hypertension Oral 20 mg Tablet t.i.d.

Ref :-  Book : Martindale    Page : 2398   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Pulmonary arterial hypertension > 1 Day 18 Year Oral 250 500 micrograms/kg Tablet

Ref :- Book : Martindale    Page : 2398   Edition : 37,
►  Side Effect : headache, flushing, dyspepsia, Blurred Vision, photophobia, chromatopsia, cyanopsia, eyes irritation, Pain, retinal haemorrhage, non-arteritic anterior ischaemic optic neuropathy, permanent loss of vision, Dizziness, insomnia, anxiety, vertigo, epistaxis, nasal congestion, pyrexia, gastrointestinal disturbance, diarrhea, vomiting, priapism, Skin rashes, erythema, alopecia, limb back pain, myalgia, facial oedema, fluid retention, paraesthesia, urinary-tract infections, dyspnoea, Cough, rhinitis, sinusitis, bronchitis, cellulitis, loss of hearing, anaemia, leucopenia, Gynaecomastia, urinary frequency, incontinence, haematuria, seizure, transient ischaemic attacks, palpitations, syncope, hypertension, hypotension, myocardial infarction, arrhythmia, tachycardia, unstable angina, sudden cardiac death,
Ref :-   Book : Martindale    Page : 2396   Edition : 37,

►  Drug Interaction : Drug interaction of Sildenafil is with Cimetidine , Delavirdine, Erythromycin , Itraconazole , Ketoconazole , Nicorandil , ,
Ref :-   Book : Martindale    Page : 2398   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Drugs that inhibit the cytochrome P450 isoenzyme CYP3A4, such as cimetidine, delavirdine, erythromycin, itraconazole, and ketoconazole, may reduce the clearance of phosphodiesterase type-5 inhibitors, necessitating a reduction in dosage. effects of sildenafil in men stabilised on antihypertensives in general. Grapefruit juice has been shown to increase bioavailability but delay absorption of sildenafil,
Ref :-   Book : Martindale    Page : 2398   Edition : 37,


►  Contraindication : renal impairment, hepatic impairment, non-arteritic anterior ischaemic optic neuropathy,
Ref :-   Book : Martindale    Page : 2397   Edition : 37,
  ►  Mechanism of Action :   Inhibit PDE5 an enzyme that converts cGMP TO GMP , leading to cGMP accumulation in target tissues,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 369   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Stephania tetrandra with Another pathway, Pomegranate juice with same pathway,

  ►  Pathway with its reference as follows :-
  • Tetrandrine have Cardio-protective activities --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )
  • PDE 5 ( phoshodiesterase type 5 ) inhibitor --- (rajfer, J. (2008). Pomegranate Juice: Is It the New, All-Natural Phosphodiesterase Type 5 Inhibitor?. Rev Uro, 10(2), 168–169. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483323/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- EPIMEDIUM I.E. EPIMEDIUM BREVICORNU with Potentiate the effect of phosphodiesterase type 5 inhibitor ,

      ►  Reference :-
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,

    ►   Route of Elimination :   Fecal, Renal,
    Ref :-   Book : Martindale    Page : 2398   Edition : 37,


    ►    Plasma Half-life :   Min value :-   4 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 2398   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   0.5 hour,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 2398   Edition : 37,