Silver sulphadiazine is a Medicine belongs to Sulfonamide for special applications group whose information about Brand can be referenced from   Book : Martindale    Page : 363   Edition : 38,

  ►   Brandname : SSZ,flamazine,silvadene,SSD,Thermazene

  ►  Strength : Cream with 10  mg/gm,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 837   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Topical,
Reference :-   Book : Basic & Clinical pharmacology    Page : 837   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Severe burns Topical 1 % Cream

Ref :-  Book : Martindale    Page : 362   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : burning , Pain, Itching, nausea, vomiting, anorexia, pruritus, diarrhea, photosensitivity reactions, exfoliative dermatitis, erythema nodosum, lumbar pain, haematuria, oliguria, anuria, granulocytosis, aplastic anaemia, thrombocytopenia, leucopenia, hypoprothrombinaemia, eosinophilia, hypoglycemia, hypothyroidism, neurological reactions, Aseptic memingitis, ataxia, benign intracranial hypertension, convulsion, Dizziness, drowsiness, fatigue, headache, insomnia, mental depression, peripheral or optic neuropathies, Psychosis, tinnitus, vertigo, Pancreatitis, skin reaction, toxic epidermal necrolysis, Stevens-Johnson syndrome, interstitial nephritis, tubular necrosis,
Ref :-   Book : Martindale    Page : 362, 365   Edition : 38,

►  Drug Interaction : Drug interaction of Silver sulphadiazine is with Ropinirole , Methotrexate, Phenytoin , Ropivacaine , Magnesium/Magnesium Sulphate, Procaine,
Ref :-   Book : Martindale    Page : 366   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Due to displacement of the drug from plasma protein binding sites or to inhibition of metabolism. The possibility of interactions with other highly protein-bound drugs, such as NSAIDs, should be considered. Sulfadiazine silver is not antagonised by p-aminobenzoic acid or related compounds. The silver content of sulfadiazine silver may inactivate enzymatic debriding agents,
Ref :-   Book : Martindale    Page : 366   Edition : 37,


►  Contraindication : ,
Ref :-   Book :    Page :    Edition : ,
  ►  Mechanism of Action :   Silver sulphadiazine inhibits the growth in vitro of nearly all pathogenic bacteria and fungi, including some species resistant to sulfonamides.,
Ref :-   Book : Goodman    Page : 1466   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   ,
Ref :-   Book : Goodman    Page : 1580   Edition : 12,


►    Plasma Half-life :
  Min value :-   NA    Max value :-   NA


►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA