Silver sulphadiazine is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 363   Edition : 38  

  ►   Brandname : SSZ, flamazine, silvadene, SSD, Thermazene, Burn acid
  ►  Strength : Cream with 10 mg/gm. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 837   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Topical
Reference :-   Book : Basic & Clinical pharmacology    Page : 837   Edition : 12  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Severe burns Topical 1 % Cream

Ref :-  Book : Martindale    Page : 362   Edition : 38  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :    Page :    Edition :   
►  Side Effect : Nausea, Vomiting, Anorexia, Diarrhoea, Hypersensitivity reactions, Fever, Rashes, pruritus, Photosensitivity, Exfoliative dermatitis, Erythema, Nodosum, Potentially fatal, Skin reaction, Toxic epidermal necrolysis, Stevens-Johnson syndrome, Dermatitis, Nephrotoxic, Interstitial nephritis, Tubular necrosis, Lumbar pain, Haematuria, Oliguria, Anuria, Crystalluria, Agranulocytosis, Aplastic anaemia, Thrombocytopenia, Leukopenia, Hypoprothrombinaemia, Eosinophilia, Jaundice, Hypoglycaemia, Hypothyroidism, Neurological reactions, Aseptic meningitis, Ataxia, Benign intracranial hypertension, Convulsion, Dizziness, Drowsiness, Fatigue, Headache, Insomnia, Mental depression, Peripheral neuropathies, Optic neuropathy, Psychoses, Tinnitus, Vertigo, Pancreatitis
Ref :-   Book : Martindale    Page : 362,365   Edition : 38.   Martindale    Page : 362, 365   Edition : 38.  

►  Drug Interaction : Drug interaction of Silver sulphadiazine is with , Local anaesthetics , Oral anticoagulants, Non Sterodial Anti- Inflammatory Drugs , Hormonal Contraceptives,  Methotrexate, Phenytoin , Cyclosporine
Ref :-   Book : Martindale    Page : 363,366   Edition : 38.  

  ►    Mechanism of Drug Drug Interaction :  The action of sulfonamides may be antagonised by para aminobenzoic acid and its derivatives, particularly potassium aminobenzoate and the procaine group of local anaesthetics. Silver sulphadiazine and other sulfonamides may potentiate the effects of some drugs, such as oral anticoagulants methotrexate and phenytoin this may be due to displacement of the drug from plasma protein binding sites or to inhibition of metabolism. However, the clinical significance of these interactions appears to depend on the particular sulfonamide involved. The possibility of interactions with other highly protein-bound drugs, such as NSAIDs, should be considered. High doses of sulfonamides have been reported to have a hypoglycaemic effect; the antidiabetic effect of the sulfonylurea compounds may be enhanced by sulfonamides. Some sulfonamides have been associated with a decrease in plasma-ciclosporin concentrations when used together. Isolated reports have described possible failures of hormonal contraceptives resulting in pregnancy in patients given sulfonamides. The use of compounds which render the urine acidic may increase the risk of crystalluria.
Ref :-   Book : Martindale    Page : 363,366   Edition : 38.  

►  Contraindication : , Treatment with Silver sulphadiazine should be stopped immediately if rash appears because of the danger of severe allergic reactions such as the Stevens-Johnson syndrome., Contra-indicated in patients with severe impairment or with blood disorders, Caution is also needed in the elderly, who may be more likely to have other risk factors for reactions. Some consider Silver sulphadiazine to be contra-indicated in lupus erythematosus as it may exacerbate the condition., Not usually given to infants within 1 to 2 months of birth because of the risk of producing kernicterus.
Ref :-   Book :    Page :    Edition : .   Martindale    Page : 362,366   Edition : 38.  
  ►  Mechanism of Action :   PABA analogues that competitively inhibit microbial dihydopteroate synthase and thereby prevent the synthesis of folic acid..
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 579   Edition : 3.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   NA

►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA