Simvastatin is a Medicine belongs to Dyslipidemia/ sterol absorption inhibitor group whose information about Brand can be referenced from   Book : Martindale    Page : 1532   Edition : 37,

  ►   Brandname : Zocor,Simcard,Simchol

  ►  Strength : Tablet with 5  mg, Tablet with 10  mg, Tablet with 20  mg, Tablet with 40  mg, Tablet with 80  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 633   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1530   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Cardiovascular risk reduction Oral 20 40 mg Tablet o.d. In the evening.
2 Hyperlipidaemia Oral 10 20 mg Tablet In the evening.

Ref :-  Book : Martindale    Page : 1489   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Familial hypercholesterolaemia 10 Year 17 Year Oral 10 mg Tablet h.s.
2 Hyperlipidaemia 5 Year 10 Year Oral 10 mg Tablet h.s.
3 Hyperlipidaemia 10 Year 18 Year Oral 10 mg Tablet h.s.

Ref :- Book : Martindale    Page : 1531   Edition : 37,
►  Side Effect : Acute renal failure, anaphylaxis, angioedema, Blurred Vision, Dizziness, Dysgeusia, gastrointestinal disturbance, headache, hepatitis, hypersensitivity reactions, insomnia, muscle weakness, myalgia, myopathy, Pancreatitis, rhabdomyolysis, Skin rashes,
Ref :-   Book : Martindale    Page : 1526   Edition : 37,

►  Drug Interaction : Drug interaction of Simvastatin is with Gemfibrozil , Cyclosporine , Digoxin , Warfarin , Erythromycin , Ketoconazole , Itraconazole , Danazol, Verapamil , Amiodarone ,
Ref :-   Book : Martindale    Page : 1528   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Simvastatin is metabolised by the cytochrome P450 isoenzyme CYP3A4, as are atorvastatinand lovastatin, and interactions may occur with drugs that inhibit this enzyme, including ciclosporin, itraconazole, ketoconazole, erythromycin, clarithromycin, telithromycin, HIV-protease inhibitors, nefazodone, danazol, amiodarone, and verapamil; there may also be a similar interaction with grapefruit juice. UK licensed product information contra-indicates the use of simvastatin in patients receiving potent CYP3A4 inhibitors. Fluvastatin is metabolised mainly by CYP2C9, while pravastatin and rosuvastatin are not significantly metabolised.,
Ref :-   Book : Martindale    Page : 1528   Edition : 37,


►  Contraindication : active liver disease, pregnant women, Active liver disease, pregnancy,
Ref :-   Book : Martindale    Page : 1527   Edition : 37,
  ►  Mechanism of Action :   Simvastatin is a lipid regulating drug; it is a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase), the ratedetermining enzyme for cholesterol synthesis. Inhibition of HMG-CoA reductase leads to reduced cholesterol synthesis in the liver and lower intracellular cholesterol concentrations; this stimulates an increase in low-density-lipoprotein (LDL)-cholesterol receptors on hepatocyte membranes, thereby increasing the clearance of LDL from the circulation. HMG-CoA reductase inhibitors (also called statins) reduce total cholesterol, LDL-cholesterol, and very-low-density lipoprotein (VLDL)-cholesterol concentrations in plasma. They also tend to reduce triglycerides and to increase high-density lipoprotein (HDL)-cholesterol concentrations,
Ref :-   Book : Martindale    Page : 1530   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Garlic with same pathway, Angeer with Another pathway,

  ►  Pathway with its reference as follows :-
  • HMGCoA reductase inhibitor --- (Siddiqui,, 1. (2014). EFFECTS OF HMG-COA REDUCTASE INHIBITORS (SIMVASTATIN AND HERBAL FORMULATION OF ALLIUM SATIVUM) ON LIVER FUNCTION TEST IN PATIENTS WITH TYPE 2 DIABETES MELLITUS RELATED DYSLIPIDEMIA. WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, 3(ISSN 2278 – 4357), 1791-1799. )
  • Hypolipidemic effect. --- (Joseph, Baby. "Pharmacognostic And Phytochemical Properties Of Ficus Carica Linn –An Overview". International Journal of PharmTech Research 3.1 (2017): 08-12,. Print. )

  •   ►  URL -- file:///C:/Users/Administrator/Downloads/article_wjpps_1413025339%20(3).pdf, http://sphinxsai.com/Vol.3No.1/pharm_jan-mar11/pdf/JM11(%20PT=03)%2008-12.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- IRON with Dietary Substance is Drug Inhibitor, CO Q10 with Decrease in Nutrient Level, VITAMIN A with Increase in Nutrient Level, ST JOHNS WORT with Dietary Substance is Drug Inhibitor,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20, http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf, https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NIACIN with Taking large amount of niacin along with HMG-CoA reductase inhibitors may cause muscle disorders that can become serious ., VITAMIN E with Improve blood vessel elasticity more than simvastatin alone ., COQ10 with Impairs coenzyme Q10 metabolism .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf, http://197.14.51.10:81/pmb/AGROALIMENTAIRE/Handbook%20of%20Nutrition.pdf,

    ►   Route of Elimination :   Biliary, Fecal, Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 1530   Edition : 37,


    ►    Plasma Half-life :   Min value :-   12 hours,    Max value :-   NA
    Ref :-   Book : Goodman    Page : 896   Edition : 12,


    ►    Peak Plasma Concentration :   Min value :-   1,    Max value :-   4 hours,
    Ref :-   Book : Goodman    Page : 896   Edition : 12,