Sirolimus is a Medicine belongs to Immunosuppressants group whose information about Brand can be referenced from   Book : Martindale    Page : 1968   Edition : 38  

  ►   Brandname : Rapamune, Rui Pa Ming
  ►  Strength : Oral solution with .  Tablet with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1968   Edition : 38   Martindale    Page : 1966   Edition : 38  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 1966   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 For the prevention of graft rejection in kidney transplantation Oral It is given with ciclosporin and corticosteroids as soon as possible after transplantation. A loading dose of 6 mg is given orally, followed by a maintenance dose of 2 mg daily, 4 hours after ciclosporin.

Ref :-  Book : Martindale    Page : 1966   Edition : 38  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :    Page :    Edition :   
►  Side Effect : Peripheral edema, Lymphocele, Hypokalaemia, Hypophosphataemia, Hyperlipidaemia, Hypercholesterolaemia, Hypertriglyceridaemia, Hyperglycaemia, Tachycardia, Venous thromboembolism, Gastrointestinal disturbance, Stomatitis, Arthralgia, Epistaxis, Acne, Rashes, Bone necrosis, Fever, Hypertension, Headache, Pain, Abdominal pain, Anaemia, Thrombocytopenia, Neutropenia, leucopenia, Immunosuppression, Increased incidence of lymphoma and other malignancies, Thrombotic thrombocytopenic purpura, Haemolytic uraemic syndrome, Hypersenstivity, Anaphylactic reactions, Angioedema, Exfoliative dermatitis, Hypersensitivity vasculitis, , Renal impairment, Proteinuria, Focal glomerulosclerosis, Nephrotic syndrome, Azoospermia
Ref :-   Book : Martindale    Page : 1967   Edition : 38.  

►  Drug Interaction : Drug interaction of Sirolimus is with , Hiv Protease Inhibitors, , , , , Angiotensin conveting enzyme inhibitors ,  Ketoconazole , Delavirdine, Diltiazem , Nevirapine, Rifampicin , Cyclosporine
Ref :-   Book : Martindale    Page : 1968   Edition : 38.  

  ►    Mechanism of Drug Drug Interaction :  Inhibitors of the cytochrome P450 isoenzyme CYP3A4, such as ketoconazole, HIV-protease inhibitors, the NNRTI delavirdine, and diltiazem may increase plasma concentrations of sirolimus. Conversely, inducers of this isoenzyme, such as nevirapine and rifampicin, may reduce plasma concentrations of sirolimus. Use of sirolimus with strong inhibitors or inducers of CYP3A4 and/or P-glycoprotein is not recommended. Grapefruit juice should not be taken with sirolimus. Ciclosporin can affect the rate and extent of sirolimus absorption and it is recommended that these drugs be given 4 hours apart. Use of sirolimus with a calcineurin inhibitor may also increase the risk of calcineurin inhibitor-induced haemolytic uraemic syndrome, thrombotic thrombocytopenic purpura, or thrombotic microangiopathy. Use of sirolimus with an ACE inhibitor may increase the risk of developing angioedema.
Ref :-   Book : Martindale    Page : 1968   Edition : 38.  

►  Contraindication : Exposure to UV light and excessive exposure to sunlight should be avoided., Vaccines and the use of live vaccines should be avoided, Intra-uterine devices should be used with caution during immunosuppressive therapy
Ref :-   Book : Martindale    Page : 1967   Edition : 38.  
  ►  Mechanism of Action :   Sirolimus binds to a protein (FK binding protein-12; FKBP-12) and this complex inhibits the activation of the mammalian target of rapamycin (mTOR), a key regulatory kinase for cell cycle progression thus suppressing cytokine-driven T-cell proliferation.
Ref :-   Book : Martindale    Page : 1966   Edition : 38.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Faecal, Renal
Ref :-   Book : Martindale    Page : 1968   Edition : 38.   Harrison's principles of internal medicine    Page : 1968   Edition : 38.  

►    Plasma Half-life :   Min value :-   half-life in men was reported to be significantly longer than in women ( about 72 hours hours compared with about 61 hours),    Max value :-   NA
Ref :-   Book : Martindale    Page : 1968   Edition : 38.  

►    Peak Plasma Concentration :   Min value :-   about 2 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1968   Edition : 38.