Sitagliptin Phosphate is a Medicine belongs to Antidiabetic group whose information about Brand can be referenced from   Book : Martindale    Page : 500   Edition : 38  

  ►   Brandname : Januiva
  ►  Strength : Tablet with 25 Mg.  Tablet with 50 mg.  Tablet with 100 Mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 766   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 500   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Type 2 diabetes mellitus Oral 100 mg Tablet o.d. When given with metformin sitagliptin may be given in 2 divided doses.

Ref :-  Book : Martindale    Page : 500   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Type 2 diabetes mellitus Oral 50 100 mg Tablet o.d.

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1992   Edition : 19  
►  Side Effect : Headache, Dizziness, Gastrointestinal disturbance, Peripheral edema, Rashes, Other hypersensitivity reactions including anaphylaxis, angioedema, urticaria, cutaneous vasculitis and Stevens-Johnson syndrome., Elevated liver enzyme values, Pancreatitis, Haemorrhagic and necrotizing pancreatitis, Hypoglycaemia, Upper respiratory-tract infections, Nasopharyngitis, Acute renal failure
Ref :-   Book : Martindale    Page : 500   Edition : 38.  

►  Drug Interaction : Drug interaction of Sitagliptin Phosphate is with , ,  Simvastatin , Lovastatin
Ref :-   Book : Martindale    Page : 500,1495   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  The efficacy of sitagliptin may be affected by other drugs that have an independent effect on blood glucose. Drugs that can increase or decrease blood glucose concentrations. Rhabdomyolysis and acute renal failure developd about 6 weeks after Sitagliptin.Taking Lovastatin, rhabdomyolysis developed after about 2 weeks of sitagliptin treatment.
Ref :-   Book : Martindale    Page : 500,1495   Edition : 38.  


►  Contraindication : Type 1 diabetes mellitus, Diabetic ketoacidosis
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 539   Edition : 3.  
  ►  Mechanism of Action :   Inhibits dipeptidylpeptidase-4, , an enzyme responsible, among other roles, for the degradation of the incretin hormone glucagon-like peptide-1 (GLP-1); and glucose-dependent insulinotropic polypeptide (GIP)
Ref :-   Book : Martindale    Page : 500   Edition : 38.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Jamun with same pathway.   Angeer with Another pathwayAnother pathway.   Angeer with Another pathwayAnother pathway.   Maxican oregano with same pathway.   Greek Oregano with same pathway.   Marjoram with same pathway.   Rosemary with same pathway.   Blue Berries with same pathway.  

  ►  Pathway with its reference as follows :-
  • Hypolipidemic effect. --- ( )
  • Hypolipidemic effect. --- (Joseph, Baby. "Pharmacognostic And Phytochemical Properties Of Ficus Carica Linn –An Overview". International Journal of PharmTech Research 3.1 (2017): 08-12,. Print. )
  • DPP 4 inhibitor --- ( Fan, J., Johnson, M., Lila, M., Yousef, G. and de Mejia, E. (2013). Berry and Citrus Phenolic Compounds Inhibit Dipeptidyl Peptidase IV: Implications in Diabetes Management. Evidence-Based Complementary and Alternative Medicine, 2013, pp.1-13. )
  • Maxican oregano act as DDP 4 inhibitor. --- (AM, B. (2014). Bioactive compounds from culinary herbs inhibit a molecular target for type 2 diabetes management, dipeptidyl peptidase IV. PMID: 24881464, 62(26). http://dx.doi.org/10.1021/jf500639f )
  • Hypolipidemic effect. --- ( )
  • Hypolipidemic effect. --- (Joseph, Baby. "Pharmacognostic And Phytochemical Properties Of Ficus Carica Linn –An Overview". International Journal of PharmTech Research 3.1 (2017): 08-12,. Print. )

  •   ►  URL --
  • http://www.hindawi.com/journals/ecam/2013/479505/ .
  • .
  • http://sphinxsai.com/Vol.3No.1/pharm_jan-mar11/pdf/JM11(%20PT=03)%2008-12.pdf .
  • https://www.ncbi.nlm.nih.gov/pubmed/24881464 .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal
    Ref :-   Book : Basic & Clinical pharmacology    Page : 761   Edition : 12.  

    ►    Plasma Half-life :   Min value :-   12 hours,    Max value :-   NA
    Ref :-   Book : Basic & Clinical pharmacology    Page : 761   Edition : 12.  

    ►    Peak Plasma Concentration :   Min value :-   1 ,    Max value :-   4 hours.  
    Ref :-   Book : Basic & Clinical pharmacology    Page : 761   Edition : 12.