Sodium bicarbonate is a Medicine belongs to Electrolytes group whose information about Brand can be referenced from   Book : Basic & Clinical pharmacology    Page : 1083   Edition : 12,

  ►   Brandname : Baking soda,Alka seltzer

  ►  Strength : Tablet with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1820   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 1819   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Severe acidosis IV 1.26 % Injection
2 Alkalinise the urine Oral 10 gm Daily in divided dose.
3 Dyspepsia Oral 1 5 gm In water.

Ref :-  Book : Martindale    Page : 1781   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : hypokalaemia, metabolic alkalosis, mood changes, Tiredness, slow breathing, muscle weakness, irregular heart beat, hyperosmolality, stomach cramps, belching, Flatulence, Muscle hypertonicity, twitching, tetany, local tissue necrosis,
Ref :-   Book : Martindale    Page : 1819   Edition : 37,

►  Drug Interaction : Drug interaction of Sodium bicarbonate is with Chlorpropamide , Tetracycline , Sildenafil , Norgestrienone , Felbamate,
Ref :-   Book : Martindale    Page : 1819   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The effect of oral bicarbonate or bicarbonate forming compounds in raising intra-gastric pH may reduce or increase the rate and/or extent of absorption of a number of drugs. Alkalinisation of the urine leads to increased renal clearance of acidic drugs such as salicylates, tetracyclines, and barbiturates. Conversely, it prolongs the half-life of basic drugs and may result in toxicity. Sodium bicarbonate enhances lithium excretion.,
Ref :-   Book : Martindale    Page : 1819   Edition : 37,


►  Contraindication : Hypocalcaemia, Hypochlorhydria, respiratory alkalosis, metabolic alkalosis,
Ref :-   Book : Martindale    Page : 1819   Edition : 37,
  ►  Mechanism of Action :   Sodium bicarbonate reacts rapidly with HCl to form water, carbon dioxide, and salt.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 816   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Baking soda with same compound, Fennel with Another pathway,

  ►  Pathway with its reference as follows :-
  • Alkalinization of the blood --- (Adeva-Andany, M., Fernández-Fernández, C., Mouriño-Bayolo, D., Castro-Quintela, E., & Domínguez-Montero, A. (2014). Sodium Bicarbonate Therapy in Patients with Metabolic Acidosis. The Scientific World Journal, 2014, 1-13. )
  • terpenoid anethole have Antispasmodic effect --- (Akha, o. (2014). The effect of fennel (Foeniculum vulgare) gel 3% in decreasing hair thickness in idiopathic mild to moderate hirsutism, A randomized placebo controlled clinical trial. Caspian J Intern Med., 5(1). )

  •   ►  URL -- http://www.hindawi.com/journals/tswj/2014/627673/, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894467/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 1819   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA