Sodium fluoride is a Medicine belongs to Nutritional agents group whose information about Brand can be referenced from   Book : Martindale    Page : 2091   Edition : 38,

  ►   Brandname : Otoflour,Duraphat,En-De-Kay,Fluor-A-Day,Fluorigard,Sensodyne Mint,ACT,APF,Denta Plus,DentaGel,EtheDent,Fluorigard,Fluorinse

  ►  Strength : Tablet with 0.55  mg, Tablet with 1.1  mg, Tablet with 2.2  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 786   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Local,
Reference :-   Book : Martindale    Page : 2089   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Dental caries prophylaxis Topical 0.05 % Daily mouth-rinses.

Ref :-  Book : Martindale    Page : 2089   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Dental caries prophylaxis 6 Month 3 Year Oral 550 micrograms Tablet
2 Dental caries prophylaxis 3 Year 6 Year Oral 1.1 mg Tablet
3 Dental caries prophylaxis 6 Year <6 Year Oral 2.2 mg Tablet

Ref :- Book : Martindale    Page : 2124   Edition : 37, Martindale    Page : 2089   Edition : 38,
►  Side Effect : Salty or soapy taste, increased salivation, gastrointestinal disturbance, abdominal pain, weakness, drowsiness, faintness, shallow breathing, hypocalcaemia, hypomagnesaemia, hyperkalaemia, tremor, hyperreflexia, tetany, convulsion, cardiac arrhythmia, shock, respiratory arrest , cardiac failure, death, bone pain, stiffness, limited movement, crippling deformities, Mottled enamel, white opaque flecks on the teeth, brown to black staining, teeth pitted corroded, thyroid dysfunction, chromosome aberrations, cancer,
Ref :-   Book : Martindale    Page : 2090   Edition : 38,

►  Drug Interaction : Drug interaction of Sodium fluoride is with Tiagabine, Oxcarbazepine , Zonisamide ,
Ref :-   Book : Martindale    Page : 2091   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Aluminium, calcium, and magnesium salts may decrease the absorption of fluoride,
Ref :-   Book : Martindale    Page : 2091   Edition : 38,


►  Contraindication : renal impairment,
Ref :-   Book : Martindale    Page : 2091   Edition : 38,
  ►  Mechanism of Action :   nf,
Ref :-   Book :    Page :    Edition : ,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- water with Another pathway, Sea food with same compound, Tea with Another pathway,

  ►  Pathway with its reference as follows :-
  • Nutrient Supplement --- (Gopalan, C. (2016). Nytritive value of Indian Foods. National INstitute Of Nutrition: Indial council of Medical Research (ICMR),Hyderabad -500007 ,INDIA. )
  • Nutrient Supplement --- (Kokate, C.K. and A.p. Purohit. Pharmacognosy. Nirali prakashan: Chennai, 2013. Print. )
  • Nutrient Supplement --- (Gopalan, C. (2016). Nytritive value of Indian Foods. National INstitute Of Nutrition: Indial council of Medical Research (ICMR),Hyderabad -500007 ,INDIA. )

  •   ►  URL -- http://www.eeb.cornell.edu/biogeo/nanc/Food_Feed/table%201%20gopalan%20et%20al%201989.pdf, https://books.google.co.in/books/about/Nutritive_Value_of_Indian_Foods.html?id=biFBAAAAYAAJ,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 2091   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA