Sodium nitrite is a Medicine belongs to Chelator Antidote group whose information about Brand can be referenced from   Book : Martindale    Page : 1575   Edition : 38  

  ►   Brandname : Citrosil Alcolico Azzuro, Tripac-Cyano, Cyanide Antidote Package; Nithiodote
  ►  Strength : Injection with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1574   Edition : 38  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV
Reference :-   Book : Martindale    Page : 1574   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Severe cyanide poisoning IV 300 mg Injection Over 2 to 20 minutes followed by 12.5 g of sodium thiosulfate (50 mL of a 25% solution or 25 mL of a 50% solution) given intravenously over a period of about 10 minutes.

Ref :-  Book : Martindale    Page : 1574   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Cyanide poisoning 1 Month 18 Year IV 4 10 mg/kg Injection

Ref :- Book : Martindale    Page : 1574   Edition : 38  
►  Side Effect : Nausea, Vomiting, Abdominal pain, Dizziness, Headache, Flushing, Cyanosis, Tachypnoea, Dyspnoea, Vasodilatation, Syncope, Hypotension, Tachycardia, Blurred Vision, Confusion, Diaphoresis, Fatigue, Generalised numbness or tingling
Ref :-   Book : Martindale    Page : 1574   Edition : 38.  

►  Drug Interaction : Drug interaction of Sodium nitrite is with NA

  ►    Mechanism of Drug Drug Interaction :  N.F.R.B
Ref :-   Book :    Page :    Edition : .  


►  Contraindication : , Caution is needed when sodium nitrite is given with other drugs that may cause methaemoglobinaemia such as Procain, and Sodium nitroprusside and when used in patients with or at high risk of methaemoglobinaemia including those with congenital methaemoglobin reductase deficiency, neonates and infants under 6 months of age and those with preexisting anaemia., Cautiously with other drugs that reduce blood pressure or volume or that cause vasodilation such as antihypertensives, diuretics and phosphodiesterase type-5 inhibitor.
Ref :-   Book :    Page :    Edition : .   Martindale    Page : 1574   Edition : 38.  
  ►  Mechanism of Action :   Sodium nitrite produces methaemoglobinaemia and it is thought that cyanide ions combine with the methaemoglobin to produce cyanmethaemoglobin, thus protecting cytochrome oxidase from the cyanide ions; however, other mechanisms may have a significant role. As the cyanmethaemoglobin slowly dissociates, the cyanide is converted to relatively non-toxic thiocyanate and is excreted in the urine.
Ref :-   Book : Martindale    Page : 1574   Edition : 38.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal
Ref :-   Book : Martindale    Page : 1575   Edition : 38.  

►    Plasma Half-life :   Min value :-   21 minutes (Intravenous dosing ) to 35 minutes (Oral ingestion),    Max value :-   NA
Ref :-   Book : Martindale    Page : 1575   Edition : 38.  

►    Peak Plasma Concentration :   Min value :-   30 minutes,    Max value :-   70 minutes.  
Ref :-   Book : Martindale    Page : 1575   Edition : 38.