Sodium nitroprusside is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1498   Edition : 38  

  ►   Brandname : Sonide, Nitropress
  ►  Strength : Injection with 50 mg/vial. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 189   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV infusion
Reference :-   Book : Martindale    Page : 1497   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Hypertensive crises IV infusion 0.3 1.5 micrograms/kg/min Injection
2 Induction of hypotension IV infusion 1.5 micrograms/kg/min Injection
3 Heart failure IV infusion 10 15 micrograms/minute Injection

Ref :-  Book : Martindale    Page : 1497   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Cardiac disease Neonate IV infusion 250 500 nanograms/kg per minute Injection

Ref :- Book : Martindale    Page : 1497   Edition : 38  
►  Side Effect : Nausea, Vomiting, Apprehension, Headache, Dizziness, Restlessness, Perspiration, palpitations, Retrosternal discomfort, Abdominal pain, Muscle twitching, Tinnitus, Miosis, Arthralgia, Muscle cramp, Hyperreflexia, Confusion, Hallucinations, Convulsion, Thrombocytopenia, Phlebitis
Ref :-   Book : Martindale    Page : 1497   Edition : 38.  

►  Drug Interaction : Drug interaction of Sodium nitroprusside is with NA

  ►    Mechanism of Drug Drug Interaction :  Enhanced hypotension should be expected if sodium nitroprusside is used with other antihypertensives or drugs that produce hypotension.
Ref :-   Book : Martindale    Page : 1498   Edition : 38.  


►  Contraindication : It should be used with caution in patients with impaired hepatic and in patient with low plasma cobalamin concentration or Leber’s optic atrophy.It should also be used with caution in patients with impaired renal or pulmonary function and with particular caution in patients with impaired cerebrovascular circulation.
Ref :-   Book : Martindale    Page : 1498   Edition : 38.  
  ►  Mechanism of Action :   Nitrate and nitroprusside: Donate NO, which activates guanylyl cyclase and decreases dephosphorylation of myosin light chain in vascular smooth muscle, causing vasodilation .inhaled nitric oxide gas: selectively dilate the pulmonary vasculature.
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 368   Edition : 3.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Beet with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Vasodilator --- (18. PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL --
  • http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal
    Ref :-   Book : Martindale    Page : 1498   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   The plasma halflife of thiocyanate is reported to be about 3 days, Sodium nitroprusside is rapidly metabolised to cyanide in erythrocytes and smooth muscle Cyanide is further metabolised in the liver to thiocyanate,,    Max value :-   NA
    Ref :-   Book : Harrison's principles of internal medicine    Page : 1498   Edition : 38.  

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA