Sodium nitroprusside is a Medicine belongs to VASODILATORS group whose information about Brand can be referenced from   Book : Martindale    Page : 1533   Edition : 37,

  ►   Brandname : Sonide,Nitropress

  ►  Strength : Injection with 50  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 189   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 1534   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Hypertensive crises IV infusion 0.3 1.5 micrograms/kg/min Injection
2 Induction of hypotension IV infusion 1.5 micrograms/kg/min Injection
3 Heart failure IV infusion 10 15 micrograms/minute Injection

Ref :-  Book : Martindale    Page : 1534   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Cardiac disease > 1 Day > 28 Day IV infusion 250 500 nanograms/kg per minute Injection

Ref :- Book : Martindale    Page : 1534   Edition : 37,
►  Side Effect : nausea, vomiting,
Ref :-   Book : Martindale    Page : 1534   Edition : 37,

►  Drug Interaction : Drug interaction of Sodium nitroprusside is with Clopamide , Alteplase ,
Ref :-   Book : Martindale    Page : 1534   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Enhanced hypotension should be expected if sodium nitroprusside is used with other antihypertensives or drugs that produce hypotension,
Ref :-   Book : Martindale    Page : 1534   Edition : 37,


►  Contraindication : aortic stenosis, pregnancy, , tachyphylaxis,
Ref :-   Book : Martindale    Page : 1334   Edition : ,
  ►  Mechanism of Action :   Nitrate and nitroprusside: Donate NO, which activates guanylyl cyclase and decreases dephosphorylation of myosin light chain in vascular smooth muscle, causing vasodilation .inhaled nitric oxide gas: selectively dilate the pulmonary vasculature.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 368   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Beet with Another pathway,

  ►  Pathway with its reference as follows :-
  • Vasodilator --- (18. PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 1534   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   72 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1534   Edition : ,

    ►    Peak Plasma Concentration :   Min value :-   0.033,    Max value :-   NA
    Ref :-   Book : Goodman    Page :    Edition : 12,