Sodium stibogluconate (or meglumine antimonate) is a Medicine belongs to Antiprotozoals group whose information about Brand can be referenced from   Book : Martindale    Page : 928   Edition : 38  

  ►   Brandname : Glucantime
  ►  Strength : Injection with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 928   Edition : 38  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IM, IV, intralesional
Reference :-   Book : Martindale    Page : 927   Edition : 38   Martindale    Page : 928   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Visceral Leishmaniasis IM 20 mg/kg Injection For 28 days.
2 Cutaneous leishmaniasis Intralesional injections 100 300 mg Injection o.d/b.d If necessary at intervals of 1 to 2 days.
3 Mucocutaneous leishmaniasis IM 20 mg/kg Injection For a minimum of 4 weeks.
4 Diffuse cutaneous leishmaniasis IM 20 mg/kg Injection Daily, for a minimum of 4 weeks.

Ref :-  Book : Martindale    Page : 926   Edition : 38   Martindale    Page : 927   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Leishmania infection IM 20 mg/kg/day Injection
2 Leishmania infection IV 20 mg/kg/day Injection
3 Severe cutaneous leishmaniasis IM or IV 20 mg/kg/day Injection
4 Visceral Leishmaniasis >10 kg IM 200 mg Injection

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1189, 1190   Edition : 19   Martindale    Page : 927   Edition : 38  
►  Side Effect : Thrombophlebitis, Anorexia, Elevated amylase and lipase, Severe inflammation around the lesion and involvement of the pharynx or trachea may be life-threatening, Vomiting, Nausea, Malaise, Arthralgia, Myalgia, Headache, Lethargy, Abdominal pain, ECG changes, Prolong QT interval
Ref :-   Book : Martindale    Page : 927   Edition : 38.  

►  Drug Interaction : Drug interaction of Sodium stibogluconate (or meglumine antimonate) is with Amphotericin B
Ref :-   Book : Martindale    Page : 928   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  It was suggested that sodium stibogluconate increased the susceptibility of the myocardium to damage by amphotericin B
Ref :-   Book : Martindale    Page : 928   Edition : 38.  


►  Contraindication :
Ref :-   Book :    Page :    Edition : .  
  ►  Mechanism of Action :   The mechanism of action of antimonials is unknown.
Ref :-   Book : Basic & Clinical pharmacology    Page : 933   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal
Ref :-   Book : Martindale    Page : 928   Edition : 38.  

►    Plasma Half-life :   Min value :-   About 2 hours and that of the slow terminal phase is about 33 to 76 hours.,    Max value :-   NA
Ref :-   Book : Martindale    Page : 928   Edition : 38.  

►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
Ref :-   Book :    Page :    Edition : .